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  1. Content type: Research

    One problem with engineered genetic circuits in synthetic microbes is their stability over evolutionary time in the absence of selective pressure. Since design of a selective environment for maintaining functi...

    Authors: Sean C Sleight, Bryan A Bartley, Jane A Lieviant and Herbert M Sauro

    Citation: Journal of Biological Engineering 2010 4:12

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  2. Content type: Review

    Molecular rotors are a group of fluorescent molecules that form twisted intramolecular charge transfer (TICT) states upon photoexcitation. When intramolecular twisting occurs, the molecular rotor returns to th...

    Authors: Mark A Haidekker and Emmanuel A Theodorakis

    Citation: Journal of Biological Engineering 2010 4:11

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  3. Content type: Research

    Membrane proteins are an important class of proteins, playing a key role in many biological processes, and are a promising target in pharmaceutical development. However, membrane proteins are often difficult t...

    Authors: Karan Bansal, Ke Yang, Goutam J Nistala, Robert B Gennis and Kaustubh D Bhalerao

    Citation: Journal of Biological Engineering 2010 4:6

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  4. Content type: Research

    A polarized light scattering technique was used to monitor the performance of a continuously operated foam fractionation process. The S11 and S12 parameters, elements of the light scattering matrix, combined toge...

    Authors: Janakiraman N Swamy, Czarena L Crofcheck and MP Mengüç

    Citation: Journal of Biological Engineering 2010 4:5

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  5. Content type: Research

    Positive feedback is a common mechanism used in the regulation of many gene circuits as it can amplify the response to inducers and also generate binary outputs and hysteresis. In the context of electrical cir...

    Authors: Goutam J Nistala, Kang Wu, Christopher V Rao and Kaustubh D Bhalerao

    Citation: Journal of Biological Engineering 2010 4:4

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  6. Content type: Research

    The engineering of metabolism holds tremendous promise for the production of desirable metabolites, particularly alternative fuels and other highly reduced molecules. Engineering approaches must redirect the t...

    Authors: Christina M Agapakis, Daniel C Ducat, Patrick M Boyle, Edwin H Wintermute, Jeffrey C Way and Pamela A Silver

    Citation: Journal of Biological Engineering 2010 4:3

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  7. Content type: Research

    The highly reactive aldehyde acrolein is a very potent endogenous toxin with a long half-life. Acrolein is produced within cells after insult, and is a central player in slow and progressive "secondary injury"...

    Authors: Youngnam Cho, Riyi Shi and Richard Ben Borgens

    Citation: Journal of Biological Engineering 2010 4:2

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  8. Content type: Methodology

    Standard biological parts, such as BioBricks™ parts, provide the foundation for a new engineering discipline that enables the design and construction of synthetic biological systems with a variety of applicati...

    Authors: JChristopher Anderson, John E Dueber, Mariana Leguia, Gabriel C Wu, Jonathan A Goler, Adam P Arkin and Jay D Keasling

    Citation: Journal of Biological Engineering 2010 4:1

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  9. Content type: Research

    Synthetic biology brings together concepts and techniques from engineering and biology. In this field, computer-aided design (CAD) is necessary in order to bridge the gap between computational modeling and bio...

    Authors: Deepak Chandran, Frank T Bergmann and Herbert M Sauro

    Citation: Journal of Biological Engineering 2009 3:19

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  10. Content type: Research

    Efflux pump activity has been associated with multidrug resistance phenotypes in bacteria, compromising the effectiveness of antimicrobial therapy. The development of methods for the early detection and quanti...

    Authors: Laura Paixão, Liliana Rodrigues, Isabel Couto, Marta Martins, Pedro Fernandes, Carla CCR de Carvalho, Gabriel A Monteiro, Filipe Sansonetty, Leonard Amaral and Miguel Viveiros

    Citation: Journal of Biological Engineering 2009 3:18

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  11. Content type: Research

    Cnidocysts isolated from cnidarian organisms are attractive as a drug-delivery platform due to their fast, efficient delivery of toxins. The cnidocyst could be utilized as the means to deliver therapeutics in ...

    Authors: Shawn C Oppegard, Peter A Anderson and David T Eddington

    Citation: Journal of Biological Engineering 2009 3:17

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  12. Content type: Research

    Biological engineering will play a significant role in solving many of the world's problems in medicine, agriculture, and the environment. Recently the U.S. National Academy of Engineering (NAE) released a doc...

    Authors: Jeong-Yeol Yoon and Mark R Riley

    Citation: Journal of Biological Engineering 2009 3:16

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  13. Content type: Research

    Advances in synthetic biology will require spatio-temporal regulation of biological processes in heterologous host cells. We develop a light-switchable, two-hybrid interaction in yeast, based upon the Arabidop...

    Authors: Oxana Sorokina, Anita Kapus, Kata Terecskei, Laura E Dixon, Laszlo Kozma-Bognar, Ferenc Nagy and Andrew J Millar

    Citation: Journal of Biological Engineering 2009 3:15

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  14. Content type: Research

    Determination of lipophilicity as a tool for predicting pharmacokinetic molecular behavior is limited by the predictive power of available experimental models of the biomembrane. There is current interest, the...

    Authors: Sunday Olakunle Idowu, Morenikeji Ambali Adeyemo and Udochi Ihechiluru Ogbonna

    Citation: Journal of Biological Engineering 2009 3:14

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  15. Content type: Research

    Escherichia coli exhibits diauxic growth in sugar mixtures due to CRP-mediated catabolite repression and inducer exclusion related to phosphotransferase system enzyme activity. Replacement of the native crp gene ...

    Authors: Reza Khankal, Jonathan W Chin, Debashis Ghosh and Patrick C Cirino

    Citation: Journal of Biological Engineering 2009 3:13

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  16. Content type: Research

    The Hamiltonian Path Problem asks whether there is a route in a directed graph from a beginning node to an ending node, visiting each node exactly once. The Hamiltonian Path Problem is NP complete, achieving s...

    Authors: Jordan Baumgardner, Karen Acker, Oyinade Adefuye, Samuel Thomas Crowley, Will DeLoache, James O Dickson, Lane Heard, Andrew T Martens, Nickolaus Morton, Michelle Ritter, Amber Shoecraft, Jessica Treece, Matthew Unzicker, Amanda Valencia, Mike Waters, AMalcolm Campbell…

    Citation: Journal of Biological Engineering 2009 3:11

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  17. Content type: Research

    Bacterial cellulose has been used in the food industry for applications such as low-calorie desserts, salads, and fabricated foods. It has also been used in the paper manufacturing industry to enhance paper st...

    Authors: Kuan-Chen Cheng, Jeff M Catchmark and Ali Demirci

    Citation: Journal of Biological Engineering 2009 3:12

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  18. Content type: Research

    Gradients of morphogens pattern cell fate – a phenomenon that is especially important during development. A simple model system for studying how morphogens pattern cell behavior would overcome difficulties inh...

    Authors: Takayuki Sohka, Richard A Heins and Marc Ostermeier

    Citation: Journal of Biological Engineering 2009 3:10

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  19. Content type: Research

    The release of heavy metal-containing nanoparticles (NP) into the environment may be harmful to the efficacy of beneficial microbes that function in element cycling, pollutant degradation and plant growth. Nan...

    Authors: Priyanka Gajjar, Brian Pettee, David W Britt, Wenjie Huang, William P Johnson and Anne J Anderson

    Citation: Journal of Biological Engineering 2009 3:9

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  20. Content type: Research

    The following essay was written by a sophomore undergraduate student majoring in Bioengineering at the University of Maryland, Mr. Zachary Russ. Mr. Russ was one of 174 students who submitted a 1000–1200 word ...

    Authors: Zachary N Russ

    Citation: Journal of Biological Engineering 2009 3:7

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  21. Content type: Research

    Self-assembly of the amyloid-β peptide (Aβ) has been implicated in the pathogenesis of Alzheimer's disease (AD). As a result, synthetic molecules capable of inhibiting Aβ self-assembly could serve as therapeut...

    Authors: Adriana A Reyes Barcelo, Francisco J Gonzalez-Velasquez and Melissa A Moss

    Citation: Journal of Biological Engineering 2009 3:5

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  22. Content type: Methodology

    The engineering of many-component, synthetic biological systems is being made easier by the development of collections of reusable, standard biological parts. However, the complexity of biology makes it diffic...

    Authors: Jason R Kelly, Adam J Rubin, Joseph H Davis, Caroline M Ajo-Franklin, John Cumbers, Michael J Czar, Kim de Mora, Aaron L Glieberman, Dileep D Monie and Drew Endy

    Citation: Journal of Biological Engineering 2009 3:4

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  23. Content type: Research

    Apple juice prepared from 'Annurca' apple puree was treated with a HPCD batch system. The pH, °Brix, color parameters and microbial load of the treated apple juice were compared with those of thermally process...

    Authors: Giovanna Ferrentino, Mariacarmela Bruno, Giovanna Ferrari, Massimo Poletto and Murat O Balaban

    Citation: Journal of Biological Engineering 2009 3:3

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  24. Content type: Research

    The current knowledge of genes and proteins comes from 'naturally designed' coding and non-coding regions. It would be interesting to move beyond natural boundaries and make user-defined parts. To explore this...

    Authors: Pawan K Dhar, Chaw Su Thwin, Kyaw Tun, Yuko Tsumoto, Sebastian Maurer-Stroh, Frank Eisenhaber and Uttam Surana

    Citation: Journal of Biological Engineering 2009 3:2

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  25. Content type: Research

    Microbial communities are involved in many processes relevant to industrial and medical biotechnology, such as the formation of biofilms, lignocellulosic degradation, and hydrogen production. The manipulation ...

    Authors: Travis S Bayer, Kevin G Hoff, Chase L Beisel, Jack J Lee and Christina D Smolke

    Citation: Journal of Biological Engineering 2009 3:1

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  26. Content type: Research

    Immediately after damage to the nervous system, a cascade of physical, physiological, and anatomical events lead to the collapse of neuronal function and often death. This progression of injury processes is ca...

    Authors: Mahvash Zuberi, Peishan Liu-Snyder, Aeraj ul Haque, David M Porterfield and Richard B Borgens

    Citation: Journal of Biological Engineering 2008 2:17

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  27. Content type: Methodology

    Vibrational spectroscopic techniques are becoming increasingly important and popular because they have the potential to provide rapid and convenient solutions to routine analytical problems. Using these techni...

    Authors: Frank Leitermann, Christoph Syldatk and Rudolf Hausmann

    Citation: Journal of Biological Engineering 2008 2:13

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  28. Content type: Letters to the Editor

    Human solid tumors that are hard or firm on physical palpation are likely to be cancerous, a clinical maxim that has been successfully applied to cancer screening programs, such as breast self-examination. How...

    Authors: Nagesh Ragavendra, JW Ju, James W Sayre, Sharon Hirschowitz, Inder Chopra and Michael W Yeh

    Citation: Journal of Biological Engineering 2008 2:12

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  29. Content type: Research

    Humic acid (HA) has been found to affect the solubility, mineralization, and bound residue formation of polycyclic aromatic hydrocarbons (PAHs). However, most of the studies on the interaction between HA and P...

    Authors: Yanna Liang, Darwin L Sorensen, Joan E McLean and Ronald C Sims

    Citation: Journal of Biological Engineering 2008 2:11

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  30. Content type: Research

    Glucagon is a peptide hormone with many uses as a therapeutic agent, including the emergency treatment of hypoglycemia. Physical instability of glucagon in solution leads to problems with the manufacture, form...

    Authors: Cindy C Hoppe, Lida T Nguyen, Lee E Kirsch and John M Wiencek

    Citation: Journal of Biological Engineering 2008 2:10

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  31. Content type: Research

    Polyethylene glycol (PEG; 2000 MW, 30% by volume) has been shown to mechanically repair damaged cellular membranes and reduce secondary axotomy after traumatic brain and spinal cord injury (TBI and SCI respect...

    Authors: Andrew O Koob, Julia M Colby and Richard B Borgens

    Citation: Journal of Biological Engineering 2008 2:9

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  32. Content type: Research

    We investigated the possibility of executing DNA-based computation in living cells by engineering Escherichia coli to address a classic mathematical puzzle called the Burnt Pancake Problem (BPP). The BPP is solve...

    Authors: Karmella A Haynes, Marian L Broderick, Adam D Brown, Trevor L Butner, James O Dickson, W Lance Harden, Lane H Heard, Eric L Jessen, Kelly J Malloy, Brad J Ogden, Sabriya Rosemond, Samantha Simpson, Erin Zwack, A Malcolm Campbell, Todd T Eckdahl, Laurie J Heyer…

    Citation: Journal of Biological Engineering 2008 2:8

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  33. Content type: Research

    The following essay was written by a freshman undergraduate student majoring in Bioengineering at the University of Maryland, Mr. Zachary Russ. Mr. Russ was one of 94 students who submitted a 1000 to 1200 word...

    Authors: Zachary N Russ

    Citation: Journal of Biological Engineering 2008 2:7

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  34. Content type: Research

    Dielectrophoresis (DEP) has been regarded as a useful tool for manipulating biological cells prior to the detection of cells. Since DEP uses high AC electrical fields, it is important to examine whether these ...

    Authors: Liju Yang, Padmapriya P Banada, Arun K Bhunia and Rashid Bashir

    Citation: Journal of Biological Engineering 2008 2:6

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  35. Content type: Methodology

    The underlying goal of synthetic biology is to make the process of engineering biological systems easier. Recent work has focused on defining and developing standard biological parts. The technical standard th...

    Authors: Reshma P Shetty, Drew Endy and Thomas F Knight Jr

    Citation: Journal of Biological Engineering 2008 2:5

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  36. Content type: Research

    Although the production of poly-β-hydroxybutyrate (PHB) has many biological, energetic and environmental advantages over chemically synthesized polymers, synthetic polymers continue to be produced industrially si...

    Authors: Pratap R Patnaik

    Citation: Journal of Biological Engineering 2008 2:4

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  37. Content type: Research

    Feed-forward motifs are important functional modules in biological and other complex networks. The functionality of feed-forward motifs and other network motifs is largely dictated by the connectivity of the i...

    Authors: Advait A Apte, John W Cain, Danail G Bonchev and Stephen S Fong

    Citation: Journal of Biological Engineering 2008 2:2

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  38. Content type: Research

    We report a new approach for the simultaneous conversion of xylose and glucose sugar mixtures into products by fermentation. The process simultaneously uses two substrate-selective strains of Escherichia coli, on...

    Authors: Mark A Eiteman, Sarah A Lee and Elliot Altman

    Citation: Journal of Biological Engineering 2008 2:3

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  39. Content type: Research

    Value-added processing with respect to rice milling has traditionally treated the rice bran layer as a homogenous material that contains significant concentrations of high-value components of interest for phar...

    Authors: Rebecca Schramm, Alicia Abadie, Na Hua, Zhimin Xu and Marybeth Lima

    Citation: Journal of Biological Engineering 2007 1:9

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