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Figure 7 | Journal of Biological Engineering

Figure 7

From: Production of lentiviral vectors with enhanced efficiency to target dendritic cells by attenuating mannosidase activity of mammalian cells

Figure 7

LVs produced with DMJ can transduce a DC cell line more efficiently than LVs produced without DMJ. A human DC cell line (MUTZ-3) was employed to more accurately model human DCs, as a target for LVs produced with and without DMJ. (A) MUTZ-3 cells were differentiated for 7 days and stained for DC-SIGN expression. (B) The MUTZ-3 cells were transduced by LVs produced with or without DMJ. FUGW/SVGmu(DMJ+) transduced the MUTZ-3 cells about 25% more efficiently than FUGW/SVGmu(DMJ-). FUGW/VSVG was included as a positive control.

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Journal of Biological Engineering

ISSN: 1754-1611