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  1. Research

    Significantly enhanced biomass production of a novel bio-therapeutic strain Lactobacillus plantarum (AS-14) by developing low cost media cultivation strategy

    Probiotic bacteria are becoming an important tool for improving human health, controlling diseases and enhancing immune responses. The availability of a cost effective cultivation conditions has profound effec...

    Asma Manzoor, Javed Iqbal Qazi, Ikram ul Haq, Hamid Mukhtar and Akhtar Rasool

    Journal of Biological Engineering 2017 11:17

    Published on: 5 May 2017

  2. Research

    Synthesis of umbelliferone derivatives in Escherichia coli and their biological activities

    Umbelliferone, also known as 7-hydroxycoumarin, is a phenolic metabolite found in many familiar plants. Its derivatives have been shown to have various pharmacological and chemo-preventive effects on human hea...

    Luan Luong Chu, Ramesh Prasad Pandey, Haet Nim Lim, Hye Jin Jung, Nguyen Huy Thuan, Tae-Su Kim and Jae Kyung Sohng

    Journal of Biological Engineering 2017 11:15

    Published on: 5 April 2017

  3. Research

    Directing three-dimensional multicellular morphogenesis by self-organization of vascular mesenchymal cells in hyaluronic acid hydrogels

    Physical scaffolds are useful for supporting cells to form three-dimensional (3D) tissue. However, it is non-trivial to develop a scheme that can robustly guide cells to self-organize into a tissue with the de...

    Xiaolu Zhu, Shiva Gojgini, Ting-Hsuan Chen, Peng Fei, Siyan Dong, Chih-Ming Ho and Tatiana Segura

    Journal of Biological Engineering 2017 11:12

    Published on: 3 April 2017

  4. Review

    Strategies for using nanoprobes to perceive and treat cancer activity: a review

    Nanomedicine has seen a significant increase in research on stimuli-responsive activatable nanoprobes for tumor-specific delivery and diagnosis. The tumor microenvironment has particular characteristics that c...

    Byunghoon Kang, Aastha Kukreja, Daesub Song, Yong-Min Huh and Seungjoo Haam

    Journal of Biological Engineering 2017 11:13

    Published on: 23 March 2017

  5. Review

    Aptamer-based sandwich-type biosensors

    Sandwich-type biosensor platforms have drawn lots of attentions due to its superior features, compared to other platforms, in terms of its stable and reproducible responses and easy enhancement in the detectio...

    Ho Bin Seo and Man Bock Gu

    Journal of Biological Engineering 2017 11:11

    Published on: 13 March 2017

  6. Review

    Technical advances in global DNA methylation analysis in human cancers

    Prototypical abnormalities of genome-wide DNA methylation constitute the most widely investigated epigenetic mechanism in human cancers. Errors in the cellular machinery to faithfully replicate the global 5-me...

    Basudev Chowdhury, Il-Hoon Cho and Joseph Irudayaraj

    Journal of Biological Engineering 2017 11:10

    Published on: 1 March 2017

  7. Methodology

    Reliable measurement of E. coli single cell fluorescence distribution using a standard microscope set-up

    Quantifying gene expression at single cell level is fundamental for the complete characterization of synthetic gene circuits, due to the significant impact of noise and inter-cellular variability on the system...

    Marilisa Cortesi, Lucia Bandiera, Alice Pasini, Alessandro Bevilacqua, Alessandro Gherardi, Simone Furini and Emanuele Giordano

    Journal of Biological Engineering 2017 11:8

    Published on: 20 February 2017

  8. Research

    Influence of gold nanoparticle surface chemistry and diameter upon Alzheimer’s disease amyloid-β protein aggregation

    Deposits of aggregated amyloid-β protein (Aβ) are a pathological hallmark of Alzheimer’s disease (AD). Thus, one therapeutic strategy is to eliminate these deposits by halting Aβ aggregation. While a variety o...

    Kelly A. Moore, Kayla M. Pate, Deborah D. Soto-Ortega, Samuel Lohse, Nicholas van der Munnik, Mihyun Lim, Kaliah S. Jackson, Venetia D. Lyles, Lemeisha Jones, Nisha Glassgow, Vanessa M. Napumecheno, Shanee Mobley, Mark J. Uline, Rahina Mahtab, Catherine J. Murphy and Melissa A. Moss

    Journal of Biological Engineering 2017 11:5

    Published on: 6 February 2017

  9. Research

    Pretreatment of vinasse from the sugar refinery industry under non-sterile conditions by Trametes versicolor in a fluidized bed bioreactor and its effect when coupled to an UASB reactor

    During hydrous ethanol production from the sugar refinery industry in Mexico, vinasse is generated. Phenolic compounds and melanoidins contribute to its color and make degradation of the vinasse a difficult ta...

    Elda España-Gamboa, Teresa Vicent, Xavier Font, Jorge Dominguez-Maldonado, Blondy Canto-Canché and Liliana Alzate-Gaviria

    Journal of Biological Engineering 2017 11:6

    Published on: 23 January 2017

  10. Review

    Future developments in biosensors for field-ready Zika virus diagnostics

    Since early reports of the recent Zika virus outbreak in May 2015, much has been learned and discussed regarding Zika virus infection and transmission. However, many opportunities still remain for translating ...

    Ariana M. Nicolini, Katherine E. McCracken and Jeong-Yeol Yoon

    Journal of Biological Engineering 2017 11:7

    Published on: 23 January 2017

  11. Editorial

    Towards the 10-year milestone of Journal of Biological Engineering

    October 10th, 2016 marked the 9th anniversary for the Journal of Biological Engineering (JBE), the official journal of Institute of Biological Engineering (IBE), published by BioMed Central. We are entering into ...

    Jeong-Yeol Yoon

    Journal of Biological Engineering 2017 11:3

    Published on: 13 January 2017

  12. Research

    Single cell isolation process with laser induced forward transfer

    A viable single cell is crucial for studies of single cell biology. In this paper, laser-induced forward transfer (LIFT) was used to isolate individual cell with a closed chamber designed to avoid contaminatio...

    Yu Deng, Philippe Renaud, Zhongning Guo, Zhigang Huang and Ying Chen

    Journal of Biological Engineering 2017 11:2

    Published on: 13 January 2017

  13. Research

    Cellulolytic RoboLector – towards an automated high-throughput screening platform for recombinant cellulase expression

    Cellulases are key player in the hydrolyzation of cellulose. Unfortunately, this reaction is slow and a bottleneck in the process chain from biomass to intermediates and biofuels due to low activities of the e...

    Martina Mühlmann, Martin Kunze, Joaquim Ribeiro, Bertram Geinitz, Christian Lehmann, Ulrich Schwaneberg, Ulrich Commandeur and Jochen Büchs

    Journal of Biological Engineering 2017 11:1

    Published on: 7 January 2017

  14. Research

    Can terminators be used as insulators into yeast synthetic gene circuits?

    In bacteria, transcription units can be insulated by placing a terminator in front of a promoter. In this way promoter leakage due to the read-through from an upstream gene or RNA polymerase unspecific binding...

    Wenjiang Song, Jing Li, Qiang Liang and Mario Andrea Marchisio

    Journal of Biological Engineering 2016 10:19

    Published on: 16 December 2016

  15. Review

    Bioelectronic nose and its application to smell visualization

    There have been many trials to visualize smell using various techniques in order to objectively express the smell because information obtained from the sense of smell in human is very subjective. So far, well-...

    Hwi Jin Ko and Tai Hyun Park

    Journal of Biological Engineering 2016 10:17

    Published on: 13 December 2016

  16. Review

    The extracellular microscape governs mesenchymal stem cell fate

    Each cell forever interacts with its extracellular matrix (ECM); a stem cell relies on this interaction to guide differentiation. The stiffness, nanotopography, protein composition, stress and strain inherent ...

    William J. Hadden and Yu Suk Choi

    Journal of Biological Engineering 2016 10:16

    Published on: 21 November 2016

  17. Research

    Respiration activity monitoring system for any individual well of a 48-well microtiter plate

    Small-scale micro-bioreactors have become the cultivation vessel of choice during the first steps of bioprocess development. They combine high cultivation throughput with enhanced cost efficiency per cultivati...

    David Flitsch, Sebastian Krabbe, Tobias Ladner, Mario Beckers, Jana Schilling, Stefan Mahr, Uwe Conrath, Werner K. Schomburg and Jochen Büchs

    Journal of Biological Engineering 2016 10:14

    Published on: 27 October 2016

  18. Research

    Significantly enhancing recombinant alkaline amylase production in Bacillus subtilis by integration of a novel mutagenesis-screening strategy with systems-level fermentation optimization

    Alkaline amylase has significant potential for applications in the textile, paper and detergent industries, however, low yield of which cannot meet the requirement of industrial application. In this work, a no...

    Yingfang Ma, Wei Shen, Xianzhong Chen, Long Liu, Zhemin Zhou, Fei Xu and Haiquan Yang

    Journal of Biological Engineering 2016 10:13

    Published on: 17 October 2016

  19. Research

    Design and engineering of a transmissible antiviral defense

    We propose, model, and implement a novel system of population-level intervention against a virus. One context is a treatment against a chronic infection such as HIV. The underlying principle is a form of virus...

    Matthew L. Paff, Scott L. Nuismer, Andrew D. Ellington, Ian J. Molineux, Ryan H. May and James J. Bull

    Journal of Biological Engineering 2016 10:12

    Published on: 12 October 2016

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