Table 2 Application of black phosphorus composite hydrogel in cancer treatment
From: Research progress on black phosphorus hybrids hydrogel platforms for biomedical applications
Hydrogel matrix | Type of tumor | Highlights | Application type | References |
|---|---|---|---|---|
PLEL | HeLa tumor | High PTT efficacy and antimicrobial activity | PTT | [81] |
Cellulose | Liver cancer. Melanoma | Excellent photothermal response, enhanced stability and good flexibility and biocompatibility | PTT | [82] |
Agarose | Liver cancer | NIR controlled release of Emetine used to regulate SG formation in tumor tissues during PTT and improve tumor sensitivity to PTT | PTT/ Drug delivery | [83] |
Polypeptide | Liver cancer | The temperature-sensitive system releases bufalin by light control, reducing its side effects | PTT/ Chemotherapy | [84] |
OSA and AHA | Gastric caner | Photo-controlled release of paclitaxel effectively inhibits tumor cell proliferation | PTT/ Chemotherapy | [85] |
Pluronic F127 | Breast cancer | Photo-controlled release of gemcitabine with good photothermal efficiency and good biodegradability. | PTT/ Chemotherapy | [86] |
PAHy | HeLa tumor | Excellent gel properties, pH sensitivity and NIR responsiveness. | PTT/ Chemotherapy | [87] |
Pluronic F127 | Breast cancer | DTX with particle size dominance is continuously released to generate ROS synergistic injury to tumors | PDT/ Chemotherapy | [88] |
DNA | Breast cancer | Photo-controlled DOX release system with positive charge has high permeability, reduces drug resistance and improves survival | PTT/PDT/ Chemotherapy | [89] |
Chitosan | Lung cancer, glioblastoma, liver cancer | Temperature-sensitive cavernous system, hemostasis, antimicrobial, high penetration of the hematologic tumor barrier, capturing CuNPs, utilizing CDT and PTT of CuNPs, synergistic with aPD-L1 | PTT/CDT/IT | [90] |
pNIPAM | Breast cancer, bladder cancer | Photo-controlled release of zoledronate as a scaffold for γδT cell proliferation and activation | IT/ Drug delivery | [91] |
p (AAm-co-AAc) | Breast cancer, lung cancer | Pollen grains with their spike structure， high surface area, releasing cytokines and antibodies to proliferate and activate T cells | IT/ Drug delivery | [92] |
Pluronic F-127 | Lung cancer | Heat-sensitive, controlled release GM-CSF and LPS, personalized cancer vaccine, tumor antigen carrier, binding PD-1 antibody | IT/ Drug delivery | [93] |