Therapeutic angiogenesis and tissue revascularization in ischemic vascular disease

Table 1 A summary of growth factor-based therapeutic preclinical studies in IVD

GF	Disease	Function	Research types	Ref
VEGF	CHD	Increase endothelial cell proliferation and angiogenesis	Animal	[26]
VEGF-A	CHD	Promote angiogenesis through initiating ROS-ER stress-autophagy axis	Cellular and Animal	[27]
HGF	CHD	Anti‐apoptosis	Animal	[28]
HGF	CHD	Anti-apoptosis and promote angiogenesis	Cellular and Animal	[29]
FGF-2	PAD	Promote angiogenesis	Animal	[30]
FGF	CAD	Promote angiogenesis	Animal	[31]
FGF	CHD	Promote angiogenesis	Animal	[32]
PDGF	CHD	Promote angiogenesis	Animal	[33]
PDGF BB	PAD	Promote angiogenesis	Animal	[30]
PDGF-C	PAD	Promote angiogenesis	Animal	[34]
GDF-15	CHD	Anti‐apoptosis and promote angiogenesis	Animal	[35]
IGF-1	CHD	Reduce fibrosis	Animal	[36]

CHD Coronary heart disease, FGF Fibroblast growth factor, GDF Growth differentiation factor, GF Growth factor, HGF Hepatocyte growth factor, IGF Insulin-like growth factors, IVD Ischemic vascular disease, PAD Peripheral artery disease, PDGF Platelet-derived growth factor, ROS-ER Reactive oxygen species-endoplasmic reticulum, VEGF Vascular endothelial growth factor

ISSN: 1754-1611