Therapeutic angiogenesis and tissue revascularization in ischemic vascular disease

Table 3 A summary of stem cell-based therapeutic preclinical studies in IVD

Cells	Disease	Function	Research types	Ref
BMSCs	CHD	Modulate immune response	Animal	[70]
BMSCs	PAD	Perfusion recovery Running capability increased	Animal	[71]
ADSCs	PAD	Muscle function improved Perfusion increased Inflammatory infiltrate reduced	Animal	[72]
ADSCs	CAD	Angiogenesis Neurogenesis	Animal	[73]
HUCMSCs	CHD	Improve cardiac systolic function Reduce cardiac fibrosis Suppress cell apoptosis Promote cell proliferation Angiogenesis	Animal	[74]
	PAD	Promote angiogenesis Improve blood perfusion	Animal	[27]
	CAD	Suppress inflammatory responses and neuronal apoptosis	Animal	[75]
	CAD	Decrease brain injury loss Reduce neurological function deficits Increase VEGF expression	Animal	[76]
EPCs	CAD	Angiogenesis	Animal	[77]
EPCs	PAD	Angiogenesis	Animal	[78]
iPSCs	CHD	Improve cardiac function	Animal	[79]
	CHD	Inhibit ventricular remodeling	Animal	[80]
	CHD	Improve cardiac function	Animal	[81, 82]

ADSCs Adipose tissue derived stem cells, CAD Carotid artery disease, CHD Coronary heart disease, EPCs Endothelial progenitor cells, HUCMSCs Human umbilical cord mesenchymal stem cells, iPSCs Induced pluripotent stem cells, IVD Ischemic vascular disease, MSCs Mesenchymal stem cells, PAD Peripheral artery disease

ISSN: 1754-1611