Therapeutic angiogenesis and tissue revascularization in ischemic vascular disease

Table 5 A summary of material (including nanomedicine and biomaterials) -based therapeutic preclinical studies in IVD

Nanomaterials/ biomaterials	Disease	Function	Research types	Ref
MSC-exosomes	ischemic diseases	Promote angiogenesis	Animal	[119]
Magnetic nanoparticles (consist of a Fe3O4 core and a silica shell)	CHD	Promote angiogenesis	Animal	[122]
HA hydrogel	PAD	Prolong the release of VEGF, reduce lipid oxidation and enhance local blood flow	Animal	[136]
FA-gel	PAD	Promote angiogenesis	Cellular and Animal	[137]
CS-NO	PAD	Promote angiogenesis	Cellular and Animal	[151]
PF hydrogel (VEGF and ANG-1 were incorporated)	CAD	Promote angiogenesis and provide mechanical support	Cellular and Animal	[152]

ANG-1 Angiopoietin-1, CAD Carotid artery disease, CHD Coronary heart disease, CS-NO Nitric oxide-releasing chitosan hydrogel, FA Ferulic acid, HA Hyaluronic acid, IVD Ischemic vascular disease, PAD Peripheral artery disease, PF Polyethylene glycol-fibrinogen, VEGF Vascular endothelial growth factor

ISSN: 1754-1611