Table 2 Cell lines for BCBM preclinical models
From: Breast cancer brain metastasis: from etiology to state-of-the-art modeling
Models | Cell Type | Subtype | Animal model | References |
|---|---|---|---|---|
Xenogeneic | MA11 | TN | BALB/C nu/nu nude mice | [69] |
MDA-MB-231BR | TN | Nude mice | ||
MDA-MB-231BR1, -BR2, -BR3 | TN | Athymic NCr-nu/nu mice | [73] | |
MDA-MB- 231-BrM2 | TN | Athymic nude mice | [74] | |
MDA-MB-231BR-HER2 +  | ER-/PR-/HER2 +  | BALB/c nude mice | ||
MDA-MB-361 | ER + /PR + /HER2 +  | Nude mice | [77] | |
MDA-MB-468 | TN | Nude mice | [78] | |
CN34-BrM2 | TN | Athymic nude mice | [79] | |
JIMT-1-BR3 | HER2 +  | NRC nu/nu mice | [73] | |
SUM190-BR3 | HER2 +  | Athymic NIH nu/nu mice | [80] | |
BT474.br/Br.2/Br.3 | ER + /PR + /HER2 +  | Swiss nude mice | ||
SKBrM3 +  | ER-/PR-/HER2 +  | Athymic nude mice | [83] | |
Syngeneic | 4T1BM | TN | Syngeneic BALB/c mice | [84] |
4T1Br4 | TN | Syngeneic BALB/c mice | ||
4T1-Luc | TN | Syngeneic BALB/c mice | [87] | |
Br7-C5 | Unspecified | Berlin–Druckrey IV rat | [88] | |
TBCP-1 | ER-/PR-/HER2 +  | Syngeneic BALB/C mice | [89] | |
PDX | F2-7 | TN | NSG mice | [90] |
Brain-orthotopic PDXs | TN and ER + varied | NSG mice | [91] | |
BM-E22-1 | TN | NSG mice | [90] | |
DF-BM#Ni7, DF-BM#656 | ER + HER2 + (DF-BM#Ni7), TNBC (DF-BM#656) | NOD/SCID mice | [92] | |
WHIM 2/WHIM5 | TN | NOD/SCID mice | [93] | |
PDX1435/PDX2147 | TN | NOD/SCID mice | [70] | |
Orthotopic HER2 + PDXs | HER2 + , ER/PR status varied | NOD/SCID mice | [94] | |
Subcoutaneos PDXs | Unspecified | SCID BALB/c mice | [95] |