Fig. 1

Interaction of biotin coated PC12 cells with streptavidin magnetic particles. A Illustration of biotinylated cells conjugated to streptavidin magnetic particles (not in scale). B Flow cytometry CY3 representative results. C HR-SEM images of biotinylated cells labeled with MMP-SA. D TEM images of biotinylated cell membrane labeled with MMP-SA. E XTT cell viability assay. The cell viability was calculated after 72 h. Results are normalized to control. F-I Phase contrast images of PC12 cells with different treatments. J Percent of cells (n = 102) conjugated to particles (%). K The average number of particles per cell (n = 102). L Average neurite length of PC12 cells. The average quantification of three experiments is presented in the plots (mean ± STDEV). There were significant differences in some of the experiments. ***P < 0.001