Fig. 6

A magneto microfluidic sensor based on SERS for A.actinomycetemcomitans and P. gingivalis detection. The creation of a simple, quick, and accurate technique for identifying the bacteria causing periodontal disease was reported in this study. Furthermore, scientists demonstrated that strains of A. actinomycetemcomitans and P. gingivalis may be found and identified in clinical samples like human saliva. The Fe2O3@Ag magnetic NPs, the microfluidic chip, and the Si/Ag platform were used for this. Consequently, bacterial-NP aggregation formation, magnetic separation, and bacterial Raman signal augmentation were accomplished. Detecting low amounts of bacteria in clinical samples is more accessible by the comparatively high SERS signal acquired. Furthermore, researchers can distinguish 89% of the strains of A. actinomycetemcomitans from P. gingivalis using PCA on bacteria suspended in human saliva. Moreover, the sample may be created quickly and without labels [113]