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  1. Research

    Flow-dependent fluorescence of CCVJ

    The molecular rotor 9-(2-Carboxy-2-cyanovinyl)julolidine (CCVJ) is presumed to have a sensitivity towards velocity or shear which is supposed to result in a change in fluorescence quantum yield. Furthermore, a...

    Markus J. Schmidt, David Sauter and Thomas Rösgen

    Journal of Biological Engineering 2017 11:24

    Published on: 3 August 2017

  2. Research

    A computational study of VEGF production by patterned retinal epithelial cell colonies as a model for neovascular macular degeneration

    The configuration of necrotic areas within the retinal pigmented epithelium is an important element in the progression of age-related macular degeneration (AMD). In the exudative (wet) and non-exudative (dry) ...

    Qanita Bani Baker, Gregory J. Podgorski, Elizabeth Vargis and Nicholas S. Flann

    Journal of Biological Engineering 2017 11:26

    Published on: 2 August 2017

  3. Research

    Investigation of poly(γ-glutamic acid) production via online determination of viscosity and oxygen transfer rate in shake flasks

    Poly(γ-glutamic acid) (γ-PGA) is a biopolymer with many useful properties making it applicable for instance in food and skin care industries, in wastewater treatment, in biodegradable plastics or in the pharma...

    Lena Regestein née Meissner, Julia Arndt, Thomas G. Palmen, Tim Jestel, Hitoshi Mitsunaga, Eiichiro Fukusaki and Jochen Büchs

    Journal of Biological Engineering 2017 11:23

    Published on: 12 July 2017

  4. Methodology

    Prediction of Escherichia coli expression performance in microtiter plates by analyzing only the temporal development of scattered light during culture

    Escherichia coli is often used for recombinant protein production. The expression of recombinant proteins negatively affects the microbial growth, thus, a balance between protein expre...

    Tobias Ladner, Martina Mühlmann, Andreas Schulte, Georg Wandrey and Jochen Büchs

    Journal of Biological Engineering 2017 11:20

    Published on: 3 July 2017

  5. Research

    Significantly enhanced biomass production of a novel bio-therapeutic strain Lactobacillus plantarum (AS-14) by developing low cost media cultivation strategy

    Probiotic bacteria are becoming an important tool for improving human health, controlling diseases and enhancing immune responses. The availability of a cost effective cultivation conditions has profound effec...

    Asma Manzoor, Javed Iqbal Qazi, Ikram ul Haq, Hamid Mukhtar and Akhtar Rasool

    Journal of Biological Engineering 2017 11:17

    Published on: 5 May 2017

  6. Research

    Synthesis of umbelliferone derivatives in Escherichia coli and their biological activities

    Umbelliferone, also known as 7-hydroxycoumarin, is a phenolic metabolite found in many familiar plants. Its derivatives have been shown to have various pharmacological and chemo-preventive effects on human hea...

    Luan Luong Chu, Ramesh Prasad Pandey, Haet Nim Lim, Hye Jin Jung, Nguyen Huy Thuan, Tae-Su Kim and Jae Kyung Sohng

    Journal of Biological Engineering 2017 11:15

    Published on: 5 April 2017

  7. Research

    Directing three-dimensional multicellular morphogenesis by self-organization of vascular mesenchymal cells in hyaluronic acid hydrogels

    Physical scaffolds are useful for supporting cells to form three-dimensional (3D) tissue. However, it is non-trivial to develop a scheme that can robustly guide cells to self-organize into a tissue with the de...

    Xiaolu Zhu, Shiva Gojgini, Ting-Hsuan Chen, Peng Fei, Siyan Dong, Chih-Ming Ho and Tatiana Segura

    Journal of Biological Engineering 2017 11:12

    Published on: 3 April 2017

  8. Review

    Strategies for using nanoprobes to perceive and treat cancer activity: a review

    Nanomedicine has seen a significant increase in research on stimuli-responsive activatable nanoprobes for tumor-specific delivery and diagnosis. The tumor microenvironment has particular characteristics that c...

    Byunghoon Kang, Aastha Kukreja, Daesub Song, Yong-Min Huh and Seungjoo Haam

    Journal of Biological Engineering 2017 11:13

    Published on: 23 March 2017

  9. Review

    Aptamer-based sandwich-type biosensors

    Sandwich-type biosensor platforms have drawn lots of attentions due to its superior features, compared to other platforms, in terms of its stable and reproducible responses and easy enhancement in the detectio...

    Ho Bin Seo and Man Bock Gu

    Journal of Biological Engineering 2017 11:11

    Published on: 13 March 2017

  10. Review

    Technical advances in global DNA methylation analysis in human cancers

    Prototypical abnormalities of genome-wide DNA methylation constitute the most widely investigated epigenetic mechanism in human cancers. Errors in the cellular machinery to faithfully replicate the global 5-me...

    Basudev Chowdhury, Il-Hoon Cho and Joseph Irudayaraj

    Journal of Biological Engineering 2017 11:10

    Published on: 1 March 2017

  11. Methodology

    Reliable measurement of E. coli single cell fluorescence distribution using a standard microscope set-up

    Quantifying gene expression at single cell level is fundamental for the complete characterization of synthetic gene circuits, due to the significant impact of noise and inter-cellular variability on the system...

    Marilisa Cortesi, Lucia Bandiera, Alice Pasini, Alessandro Bevilacqua, Alessandro Gherardi, Simone Furini and Emanuele Giordano

    Journal of Biological Engineering 2017 11:8

    Published on: 20 February 2017

  12. Research

    Influence of gold nanoparticle surface chemistry and diameter upon Alzheimer’s disease amyloid-β protein aggregation

    Deposits of aggregated amyloid-β protein (Aβ) are a pathological hallmark of Alzheimer’s disease (AD). Thus, one therapeutic strategy is to eliminate these deposits by halting Aβ aggregation. While a variety o...

    Kelly A. Moore, Kayla M. Pate, Deborah D. Soto-Ortega, Samuel Lohse, Nicholas van der Munnik, Mihyun Lim, Kaliah S. Jackson, Venetia D. Lyles, Lemeisha Jones, Nisha Glassgow, Vanessa M. Napumecheno, Shanee Mobley, Mark J. Uline, Rahina Mahtab, Catherine J. Murphy and Melissa A. Moss

    Journal of Biological Engineering 2017 11:5

    Published on: 6 February 2017

  13. Review

    Future developments in biosensors for field-ready Zika virus diagnostics

    Since early reports of the recent Zika virus outbreak in May 2015, much has been learned and discussed regarding Zika virus infection and transmission. However, many opportunities still remain for translating ...

    Ariana M. Nicolini, Katherine E. McCracken and Jeong-Yeol Yoon

    Journal of Biological Engineering 2017 11:7

    Published on: 23 January 2017

  14. Research

    Pretreatment of vinasse from the sugar refinery industry under non-sterile conditions by Trametes versicolor in a fluidized bed bioreactor and its effect when coupled to an UASB reactor

    During hydrous ethanol production from the sugar refinery industry in Mexico, vinasse is generated. Phenolic compounds and melanoidins contribute to its color and make degradation of the vinasse a difficult ta...

    Elda España-Gamboa, Teresa Vicent, Xavier Font, Jorge Dominguez-Maldonado, Blondy Canto-Canché and Liliana Alzate-Gaviria

    Journal of Biological Engineering 2017 11:6

    Published on: 23 January 2017

  15. Research

    Single cell isolation process with laser induced forward transfer

    A viable single cell is crucial for studies of single cell biology. In this paper, laser-induced forward transfer (LIFT) was used to isolate individual cell with a closed chamber designed to avoid contaminatio...

    Yu Deng, Philippe Renaud, Zhongning Guo, Zhigang Huang and Ying Chen

    Journal of Biological Engineering 2017 11:2

    Published on: 13 January 2017

  16. Editorial

    Towards the 10-year milestone of Journal of Biological Engineering

    October 10th, 2016 marked the 9th anniversary for the Journal of Biological Engineering (JBE), the official journal of Institute of Biological Engineering (IBE), published by BioMed Central. We are entering into ...

    Jeong-Yeol Yoon

    Journal of Biological Engineering 2017 11:3

    Published on: 13 January 2017

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