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  1. Kaposiform hemangioendothelioma (KHE) is a rare intermediate vascular tumor with unclear pathogenesis. Recently, three dimensional (3D) cell spheroids and organoids have played an indispensable role in the stu...

    Authors: Yanan Li, Xinglong Zhu, Li Li, Chunjuan Bao, Qin Liu, Ning zhang, Ziyan He, Yi Ji and Ji Bao
    Citation: Journal of Biological Engineering 2024 18:21
  2. Advancements in digital technology have brought modelling to the forefront in many disciplines from healthcare to architecture. Mathematical models, often represented using parametrised sets of ordinary differ...

    Authors: Linda Wanika, Joseph R. Egan, Nivedhitha Swaminathan, Carlos A. Duran-Villalobos, Juergen Branke, Stephen Goldrick and Mike Chappell
    Citation: Journal of Biological Engineering 2024 18:20
  3. Recent therapeutic-plasmid DNA vaccine strategies for rheumatoid arthritis (RA) have significantly improved. Our pcDNA-CCOL2A1 vaccine is the most prominent and the first antigen-specific tolerising DNA vaccin...

    Authors: Juan Long, Xiao Zhao, Fei Liang, Yang Zeng, Nan Liu, Yuying Sun and Yongzhi Xi
    Citation: Journal of Biological Engineering 2024 18:19
  4. Diabetic retinopathy (DR) is a condition that causes swelling of the blood vessels of the retina and leaks blood and fluids. It is the most severe form of diabetic eye disease. It causes vision loss in its adv...

    Authors: Yan Lv, Chenglei Zhai, Gang Sun and Yangfang He
    Citation: Journal of Biological Engineering 2024 18:18
  5. The extracellular matrix (ECM) is a three-dimensional network of proteins that encases and supports cells within a tissue and promotes physiological and pathological cellular differentiation and functionality....

    Authors: Anna-Maria Diedrich, Assal Daneshgar, Peter Tang, Oliver Klein, Annika Mohr, Olachi A. Onwuegbuchulam, Sabine von Rueden, Kerstin Menck, Annalen Bleckmann, Mazen A. Juratli, Felix Becker, Igor M. Sauer, Karl H. Hillebrandt, Andreas Pascher and Benjamin Struecker
    Citation: Journal of Biological Engineering 2024 18:17
  6. Due to loss of peripheral nerve structure and/or function resulting from trauma, accidents, and other causes, peripheral nerve injuries continue to be a major clinical problem. These injuries can cause partial...

    Authors: Mehran Nabipour, Amir Mellati, Mozhgan Abasi, Somayeh Ebrahimi Barough, Ayoob Karimizade, Parnian Banikarimi and Elham Hasanzadeh
    Citation: Journal of Biological Engineering 2024 18:16
  7. Recombinant adeno-associated virus (rAAV) has been developed as a safe and effective gene delivery vehicle to treat rare genetic diseases. This study aimed to establish a novel biomanufacturing process to achi...

    Authors: Kai Chen, Seulhee Kim, Siying Yang, Tanvi Varadkar, Zhuoxin Zora Zhou, Jiashuai Zhang, Lufang Zhou and Xiaoguang Margaret Liu
    Citation: Journal of Biological Engineering 2024 18:15
  8. Bone metastasis is considered as a considerable challenge for breast cancer patients. Various in vitro and in vivo models have been developed to examine this occurrence. In vitro models are employed to simulat...

    Authors: Hanieh Kolahi Azar, Maliheh Gharibshahian, Mohammadreza Rostami, Vahid Mansouri, Leila Sabouri, Nima Beheshtizadeh and Nima Rezaei
    Citation: Journal of Biological Engineering 2024 18:14
  9. Bone tissue engineering necessitates a stem cell source capable of osteoblast differentiation and mineralized matrix production. Dental pulp stem cells (DPSCs), a subtype of mesenchymal stem cells from human t...

    Authors: Zaynab Sadeghi Ghadi, Amin Asadi, Younes Pilehvar, Mozhgan Abasi and Pedram Ebrahimnejad
    Citation: Journal of Biological Engineering 2024 18:13
  10. Polymeric nanoparticles can be used for wound closure and therapeutic compound delivery, among other biomedical applications. Although there are several nanoparticle obtention methods, it is crucial to know th...

    Authors: Stephany Celeste Gutiérrez-Ruíz, Hernán Cortes, Maykel González-Torres, Zainab M. Almarhoon, Eda Sönmez Gürer, Javad Sharifi-Rad and Gerardo Leyva-Gómez
    Citation: Journal of Biological Engineering 2024 18:12
  11. Disc degeneration often leads to a highly prevalent symptom known as low back pain. Healthy nucleus pulposus tissue exhibited a hypoxic environment devoid of blood vessels, while degenerated nucleus pulposus e...

    Authors: Zhencong Li, Weilin Zhang, Shengbang Huang, Zhiwen Dai, Jinguo Liang, Qiulan Qiu, Siyuan Chen, Weixiong Guo, Zhongwei Wang and Jinsong Wei
    Citation: Journal of Biological Engineering 2024 18:11
  12. This paper investigates the impact of taurine as an additive on the structural and functional stability of urate oxidase. First, the effect of the processing parameters for the stabilization of Urate Oxidase (...

    Authors: Parisa Shahmoradipour, Maryam Zaboli and Masoud Torkzadeh-Mahani
    Citation: Journal of Biological Engineering 2024 18:10
  13. Viral vectors are attractive gene delivery vehicles because of their broad tropism, high transduction efficiency, and durable expression. With no risk of integration into the host genome, the vectors developed...

    Authors: Takumi Kishimoto, Ken Nishimura, Kana Morishita, Aya Fukuda, Yusaku Miyamae, Yutaro Kumagai, Kimio Sumaru, Mahito Nakanishi, Koji Hisatake and Masayuki Sano
    Citation: Journal of Biological Engineering 2024 18:9
  14. Gene delivery to, and expression in, the mouse brain is important for understanding gene functions in brain development and disease, or testing gene therapies. Here, we describe an approach to express a transg...

    Authors: Osama Ahmed, Kingsley M. Ekumi, Francesco V. Nardi, Gulimiheranmu Maisumu, Khaled Moussawi, Eric D. Lazartigues, Bo Liang and Abraam M. Yakoub
    Citation: Journal of Biological Engineering 2024 18:8
  15. Retinal pigment epithelium (RPE) cell therapy is a promising way to treat many retinal diseases. However, obtaining transplantable RPE cells is time-consuming and less effective. This study aimed to develop no...

    Authors: Wenxuan Wang, Tingting Yang, Sihui Chen, Liying Liang, Yingxin Wang, Yin Ding, Wei Xiong, Xiuhong Ye, Yonglong Guo, Shuhao Shen, Hang Chen and Jiansu Chen
    Citation: Journal of Biological Engineering 2024 18:7
  16. Neurological gait disorders are mainly classified based on clinical observation, and therefore difficult to objectify or quantify. Movement analysis systems provide objective parameters, which may increase dia...

    Authors: Chuh-Hyoun Na, Hannah Lena Siebers, Julia Reim, Jörg Eschweiler, Frank Hildebrand, Hans Clusmann and Marcel Betsch
    Citation: Journal of Biological Engineering 2024 18:6
  17. Maternal secretion of recombinant proteins into chicken eggs may provide a viable approach for pharmaceutical production but remains limited by poor secretion efficiency through the membrane of oviduct cells, ...

    Authors: Long Xie, Zhenwen Huang, Meiyu Lan, Yaqi Cao, Lingling Sun, Lang Zhang, Erwei Zuo and Yangqing Lu
    Citation: Journal of Biological Engineering 2024 18:5
  18. The sequence of a carboxy-terminal of the β-lactam sensor-transducer protein (BlaR-CTD) from Bacillus licheniformis ATCC14580 was extracted from US7745193B2 patent and expressed in E. coli using pColdI vector ...

    Authors: Mohadeseh Haji Abdolvahab, Mojdeh Safari, Farkhonde Hasannejad, Nika Asefi, Alireza Salimi and Mahboobeh Nazari
    Citation: Journal of Biological Engineering 2024 18:4
  19. Large skin wounds are one of the most important health problems in the world. Skin wound repair and tissue regeneration are complex processes involving many physiological signals, and effective wound healing r...

    Authors: Yongkang Dong, Zheng Wang, Jiapeng Wang, Xuedi Sun, Xiaoyu Yang and Guomin Liu
    Citation: Journal of Biological Engineering 2024 18:3
  20. Effluents from Food Services Establishments (FSEs) contain primarily Fats, Oil and Grease (FOG) which severely impact on sewers and the environment when released in high concentrations. In Trinidad & Tobago, i...

    Authors: Cudjoe Shamika, Banerjee Goutam and Cooper Vincent
    Citation: Journal of Biological Engineering 2024 18:2
  21. The long-term nonunion of bone defects is always a difficult problem in orthopaedics treatment. Artificial bone implants made of polymeric materials are expected to solve this problem due to their suitable deg...

    Authors: Chenglong Wang, Jinlei Dong, Fanxiao Liu, Nan Liu and Lianxin Li
    Citation: Journal of Biological Engineering 2024 18:1
  22. In view of its high mechanical performance, outstanding aesthetic qualities, and biological stability, zirconia has been widely used in the fields of dentistry. Due to its potential to produce suitable advance...

    Authors: Guanyu Su, Yushi Zhang, Chunyu Jin, Qiyue Zhang, Jiarui Lu, Zengqian Liu, Qiang Wang, Xue Zhang and Jia Ma
    Citation: Journal of Biological Engineering 2023 17:78
  23. Three-dimensional (3D) cell cultures are to date the gold standard in biomedical research fields due to their enhanced biological functions compared to conventional two-dimensional (2D) cultures. 3D cell spher...

    Authors: Michael Killinger, Adéla Kratochvilová, Eva Ingeborg Reihs, Eva Matalová, Karel Klepárník and Mario Rothbauer
    Citation: Journal of Biological Engineering 2023 17:77
  24. Human mesenchymal stem cells (hMSCs) are being researched for cell-based therapies due to a host of unique properties, however, genetic modification of hMSCs, accomplished through nonviral gene delivery, could...

    Authors: Tyler Kozisek, Luke Samuelson, Andrew Hamann and Angela K. Pannier
    Citation: Journal of Biological Engineering 2023 17:76
  25. Nerve growth factor (NGF) is a vital cytokine that plays a crucial role in the development and regeneration of the nervous system. It has been extensively studied for its potential therapeutic applications in ...

    Authors: Nan Zhou, TingWei Gu, Yang Xu, Yuda Liu and LiHua Peng
    Citation: Journal of Biological Engineering 2023 17:75
  26. Reconstruction of severe osteochondral defects in articular cartilage and subchondral trabecular bone remains a challenging problem. The well-integrated bilayer osteochondral graft design expects to be guided ...

    Authors: Chih-Yun Lee, Swathi Nedunchezian, Sung-Yen Lin, Yu-Feng Su, Che-Wei Wu, Shun-Cheng Wu, Chung-Hwan Chen and Chih-Kuang Wang
    Citation: Journal of Biological Engineering 2023 17:74
  27. Due to their outstanding structures and properties, three-dimensional (3D) hydrogels and nanoparticles have been widely studied and indicated a very high potential for medical, therapeutic, and diagnostic appl...

    Authors: Negar Karimi Hajishoreh, Mehdi Dadashpour and Abolfazl Akbarzadeh
    Citation: Journal of Biological Engineering 2023 17:73
  28. Biomimetic materials are able to mimic the structure and functional properties of native tissues especially natural oral tissues. They have attracted growing attention for their potential to achieve configurab...

    Authors: Xinyu Luo, Jiayue Niu, Guanyu Su, Linxi Zhou, Xue Zhang, Ying Liu, Qiang Wang and Ningning Sun
    Citation: Journal of Biological Engineering 2023 17:72
  29. Electrical stimulation is used for enhanced bone fracture healing. Electrochemical processes occur during the electrical stimulation at the electrodes and influence cellular reactions. Our approach aimed to di...

    Authors: Meike Bielfeldt, Kai Budde-Sagert, Nikolai Weis, Maren Buenning, Susanne Staehlke, Julius Zimmermann, Nils Arbeiter, Sahba Mobini, María Ujué González, Henrike Rebl, Adelinde Uhrmacher, Ursula van Rienen and Barbara Nebe
    Citation: Journal of Biological Engineering 2023 17:71
  30. Developing new strategies to restore fertility in patients with chemotherapy-induced Premature Ovarian Failure (Chemo-POF) is important. We aimed to construct an Artificial Ovary (AO) by seeding Human Ovarian ...

    Authors: Sara Khaleghi, Farideh Eivazkhani, Somayeh Tavana, Ashraf Moini, Marefat Ghaffari Novin, Petkov Stoyan, Hamid Nazarian and Rouhollah Fathi
    Citation: Journal of Biological Engineering 2023 17:70
  31. A novel cost-effective and multifunctional nanocomposite was developed based on sustainable macroalgae biomass. The brown seaweed Sargassum latifolium was utilized for alginate extraction and the calcareous red s...

    Authors: Mohamed Gomaa and Amal William Danial
    Citation: Journal of Biological Engineering 2023 17:69
  32. Technologies for quick and label-free diagnosis of malignancies from breast tissues have the potential to be a significant adjunct to routine diagnostics. The biophysical phenotypes of breast tissues, such as ...

    Authors: Anil Vishnu G. K., Gayatri Gogoi, Midhun C. Kachappilly, Annapoorni Rangarajan and Hardik J. Pandya
    Citation: Journal of Biological Engineering 2023 17:68
  33. The typical outcome of mammalian wound healing is scarring, a fibrotic process mediated by myofibroblast aggregation. Perfect healing in a clinical setting is relatively unexplored. Surprisingly, our previous ...

    Authors: Guokun Zhang, Dongxu Wang, Jing Ren, Jiping Li, Qianqian Guo, Liyan Shi and Chunyi Li
    Citation: Journal of Biological Engineering 2023 17:67
  34. Montmorillonite (MMt) is extensively applied as an efficient drug-carrier in designing drug delivery systems (DDS) due to its high specific surface area to load drugs. Modification of MMt via iron (Fe) blendin...

    Authors: Zahra Sayyar, Gholam Reza Mahdavinia and Alireza Khataee
    Citation: Journal of Biological Engineering 2023 17:66
  35. Hydrogels are three-dimensional structures with specific features that render them useful for biomedical applications, such as tissue engineering scaffolds, drug delivery systems, and wound dressings. In recen...

    Authors: Sergio Alberto Bernal-Chávez, Sergio Alcalá-Alcalá, Zainab M. Almarhoon, Aknur Turgumbayeva, Eda Sönmez Gürer, Ma. De Los Dolores Campos-Echeverria, Hernán Cortés, Alejandra Romero-Montero, María Luisa Del Prado-Audelo, Javad Sharifi-Rad and Gerardo Leyva-Gómez
    Citation: Journal of Biological Engineering 2023 17:64
  36. The skin serves as a barrier to protect the body from environmental microorganisms and is the largest tissue of the body and any damage must be quickly and effectively repaired. The fundamental purpose of derm...

    Authors: Maryam Ghahremani-Nasab, Azizeh Rahmani Del Bakhshayesh, Naeimeh Akbari-Gharalari and Ahmad Mehdipour
    Citation: Journal of Biological Engineering 2023 17:62
  37. Multicomponent nanoparticle systems are known for their varied properties and functions, and have shown potential as gene nanocarriers. This study aims to synthesize and characterize ternary nickel–cobalt-ferr...

    Authors: Hajar Q. Alijani, Mehrdad Khatami, Masoud Torkzadeh-Mahani, Jan Michalička, Wu Wang, Di Wang and Abolfazl Heydari
    Citation: Journal of Biological Engineering 2023 17:61
  38. Calcific aortic valve disease (CAVD) causes an increasing health burden in the 21st century due to aging population. The complex pathophysiology remains to be understood to develop novel prevention and treatment ...

    Authors: Claudia Dittfeld, Maximilian Winkelkotte, Anna Scheer, Emmely Voigt, Florian Schmieder, Stephan Behrens, Anett Jannasch, Klaus Matschke, Frank Sonntag and Sems-Malte Tugtekin
    Citation: Journal of Biological Engineering 2023 17:60
  39. Mastitis poses a major threat to dairy farms globally; it results in reduced milk production, increased treatment costs, untimely compromised genetic potential, animal deaths, and economic losses. Streptococcus a...

    Authors: Rajesh Kumar Pathak and Jun-Mo Kim
    Citation: Journal of Biological Engineering 2023 17:59
  40. A number of molecular biofactors have been documented in pathogenesis and poor prognosis of colorectal cancer (CRC). Among them, the Hypoxia-Inducible Factor (HIF-1a) is frequently reported to become over-expr...

    Authors: Azar Bakand, Sevil Vaghefi Moghaddam, Maryam Naseroleslami, Helder André, Neda Mousavi-Niri and Effat Alizadeh
    Citation: Journal of Biological Engineering 2023 17:58
  41. Fungi have evolved unique metabolic regulation mechanisms for adapting to the changing environments. One of the key features of fungal adaptation is the production of secondary metabolites (SMs), which are ess...

    Authors: Wenbin Yu, Rongqiang Pei, Yufei Zhang, Yayi Tu and Bin He
    Citation: Journal of Biological Engineering 2023 17:57
  42. The use of biodegradable polymers for treating bone-related diseases has become a focal point in the field of biomedicine. Recent advancements in material technology have expanded the range of materials suitab...

    Authors: Wenqing Liang, Chao Zhou, Hongwei Zhang, Juqin Bai, Bo Jiang, Chanyi Jiang, Wenyi Ming, Hengjian Zhang, Hengguo Long, Xiaogang Huang and Jiayi Zhao
    Citation: Journal of Biological Engineering 2023 17:56
  43. Tissue-integrated micro-electronic devices for neural stimulation hold great potential in restoring the functionality of degenerated organs, specifically, retinal prostheses, which are aimed at vision restorat...

    Authors: Gal Shpun, Nairouz Farah, Yoav Chemla, Amos Markus, Tamar Azrad Leibovitch, Erel Lasnoy, Doron Gerber, Zeev Zalevsky and Yossi Mandel
    Citation: Journal of Biological Engineering 2023 17:55
  44. The approval of anticancer therapeutic strategies is still slowed down by the lack of models able to faithfully reproduce in vivo cancer physiology. On one hand, the conventional in vitro models fail to recapi...

    Authors: Elisa Cauli, Michela Anna Polidoro, Simona Marzorati, Claudio Bernardi, Marco Rasponi and Ana Lleo
    Citation: Journal of Biological Engineering 2023 17:53
  45. Radiofrequency Cardiac Ablation (RFCA) is a common procedure that heats cardiac tissue to destroy abnormal signal pathways to eliminate arrhythmias. The complex multiphysics phenomena during this procedure nee...

    Authors: Patcharaporn Wongchadakul, Ashim K. Datta and Phadungsak Rattanadecho
    Citation: Journal of Biological Engineering 2023 17:52
  46. Microfluidic devices have emerged as powerful tools for cell-based experiments, offering a controlled microenvironment that mimic the conditions within the body. Numerous cell experiment studies have successfu...

    Authors: Seungjin Lee, Jinseop Ahn, Seok-Man Kim, Daehan Kim, Jiun Yeom, Jeongmok Kim, Joong Yull Park and Buom-Yong Ryu
    Citation: Journal of Biological Engineering 2023 17:51
  47. Ischemic stroke accounts for 70–80% of all stroke cases, leading to over two million people dying every year. Poor diagnosis and late detection are the major causes of the high death and disability rate.

    Authors: Jiefeng Luo, Dingzhi Chen, Yujia Mei, Hepeng Li, Biyun Qin, Xiao Lin, Ting Fung Chan, Keng Po Lai and Deyan Kong
    Citation: Journal of Biological Engineering 2023 17:50