Figure 6

Chart of all ten four-node motifs (eight feed-forward and F – biparallel) of conversion of the source node S to target node T: A – linear, B, C, D, E, G and H – feed-forward, F and J – bi-parallel, and I – tri-parallel. The motifs are ordered according to their dynamic efficacy in producing the target product with a highest rate, assessed by decreasing number of iterations, and decreasing time, as produced by the linear (LDE) and nonlinear ODE models for 90% S → T conversion. The nonlinear irreversible and reversible ODE times are denoted by NDE and NDE', respectively. The mutual transformations of the structures shown include 15 additions of another feed-forward link, whereas those marked by an asterisk (D → F, E → I, and J → H conversions) include a reversal of a single link direction.