Figure 4
Effect of BSA inhibition of Aβ 1–40 monomer aggregation on aggregate size distribution. Aβ1–40 monomer aggregations were performed as in Figure 1 for 20 μM Aβ1–40 monomer in the presence of 0 μM (panel B, control), 40 μM (panel C), or 80 μM (panel D) BSA. In addition, 80 μM BSA was subjected to aggregation conditions in the absence of Aβ1–40 monomer (panel A). DLS was employed to determine RH distributions. Results are presented as intensity-weighted histograms derived from data regularization with Dynamics Software (Wyatt Technology). Results are representative of two independent experiments.