Figure 5
The schematic diagram of elimination of the futile cycle in an imaginary network by the FATMIN. (A) Flux distribution at steady state without employment of the FATMIN; (B) The minimization in the FATMIN to identify another constraint that can remove the futile values associated with cycles 5 and 6. The inset shows alternate path through the network, with numbers used as flux indices in the main figure. Path 3 and 4 carry no flux with reaction directions as shown, but are examples of paths that become active if reactions are made reversible.