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Table 1 Step response characteristics and worst-case parameter ranges for PI and CMC controllers + linear process

From: Exploiting the dynamic properties of covalent modification cycle for the design of synthetic analog biomolecular circuitry

PI controller

     

Characteristics

Nominal

Δ=0.2

Δ=0.5

Δ=1.0

Δ=1.2

t r (s)

29

44

75

157

173

t s (s)

96

113

175

499

Unstable

M OV (%)

9.14

22.83

52.25

114.17

Unstable

e ss (M)

0.00

0.19

0.49

0.91

Unstable

Parameters

Nominal

Δ=0.2

Δ=0.5

Δ=1.0

Δ=1.2

γ Sb1 (/s)

0.400

0.431–0.476

0.532–0.595

0.475–0.791

0.584–0.599

γ Sb2 (/s)

0.400

0.401–0.471

0.400–0.584

0.413–0.569

0.428–0.875

γ Sb3 (/s)

0.400

0.401–0.473

0.414–0.593

0.466–0.721

0.412–0.853

K I

0.045

0.048–0.054

0.048–0.061

0.052–0.086

0.058–0.085

K P

1.000

1.016–1.165

1.130–1.359

1.137–1.549

1.159–1.367

γ K1 (/s) [10 −3]

0.400

0.436–0.477

0.424–0.515

0.434–0.674

0.505–0.795

γ K2 (/s) [10 −3]

0.400

0.403–0.466

0.401–0.454

0.473–0.666

0.570–0.683

γ Sm1 (/s)

0.800

0.809–0.948

0.863–1.099

0.827–1.544

0.825–1.410

γ Sm2 (/s)

0.800

0.835–0.943

0.904–1.012

0.849–1.205

1.152–1.548

γ Sm3 (/s)

0.800

0.832–0.958

0.823–1.140

0.841–1.536

0.853–1.279

k 1 (/s)

0.100

0.101–0.116

0.106–0.142

0.111–0.174

0.127–0.208

k 2 (/s)

0.100

0.101–0.114

0.102–0.139

0.103–0.199

0.123–0.211

CMC controller

     

Characteristics

Nominal

Δ=0.2

Δ=0.5

Δ=1.0

Δ=1.2

t r (s)

29

37

65

89

117

t s (s)

97

116

155

202

353

M OV (%)

10.12

25.3

44.63

60.55

75.00

e ss (M)

0.00

0.18

0.46

0.92

1.12

Parameters

Nominal

Δ=0.2

Δ=0.5

Δ=1.0

Δ=1.2

γ Sb1 (/s)

0.400

0.403–0.476

0.450–0.595

0.412–0.781

0.626–0.857

γ Sb2 (/s)

0.400

0.401–0.477

0.406–0.580

0.407–0.752

0.403–0.745

γ Sb3 (/s)

0.400

0.403–0.466

0.402–0.594

0.577–0.726

0.425–0.806

k b1 (/M/s) [10 −2]

0.185

0.186–0.221

0.202–0.274

0.199–0.342

0.224–0.365

k b2 (/s)

0.500

0.514–0.565

0.516–0.683

0.621–0.737

0.509–0.747

k b3 (/M/s) [10 −2]

0.185

0.187–0.213

0.187–0.245

0.242–0.354

0.230–0.318

k b4 (/s)

0.500

0.516–0.596

0.679–0.723

0.553–0.851

0.662–1.008

k 1 (/s)

0.100

0.100–0.119

0.104–0.148

0.130–0.199

0.101–0.174

k 2 (/s)

0.100

0.101–0.114

0.105–0.150

0.106–0.198

0.109–0.209