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Table 2 Step response characteristics and worst-case parameter ranges for PI and CMC controllers + nonlinear process

From: Exploiting the dynamic properties of covalent modification cycle for the design of synthetic analog biomolecular circuitry

PI controller

    

Characteristics

Nominal

Δ=0.2

Δ=0.5

Δ=1.0

t r (s)

11,139

18,959

31,673

Unstable

t s (s)

26,304

44,138

48,482

Unstable

M OV (%)

2.42

24.88

44.44

Unstable

e ss (M)

0.00

0.19

0.48

Unstable

Parameters

Nominal

Δ=0.2

Δ=0.5

Δ=1.0

γ Sb1 (/s) [10 −3]

0.400

0.445-0.480

0.492-0.596

0.472-0.730

γ Sb2 (/s) [10 −3]

0.400

0.402-0.475

0.400-0.453

0.533-0.735

γ Sb3 (/s) [10 −3]

0.400

0.427-0.467

0.433-0.591

0.402-0.473

K I [10 −3]

0.300

0.301-0.353

0.310-0.420

0.486-0.504

K P

0.650

0.673-0.771

0.790-0.908

0.806-1.282

γ K1 (/s) [10 −3]

0.400

0.432-0.461

0.446-0.573

0.498-0.747

γ K2 (/s) [10 −3]

0.400

0.401-0.422

0.446-0.586

0.404-0.740

γ Sm1 (/s) [10 −3]

0.400

0.427-0.479

0.424-0.587

0.641-0.791

γ Sm2 (/s) [10 −3]

0.400

0.423-0.462

0.469-0.553

0.615-0.730

γ Sm3 (/s) [10 −3]

0.400

0.409-0.478

0.418-0.539

0.401-0.431

k r1 (/M/s) [10 −4]

0.500

0.509-0.594

0.536-0.734

0.737-0.945

k r2 (/s)

1.600

1.633-1.865

1.749-2.232

1.860-2.843

k r2 (/s) [10 −3]

0.800

0.812-0.904

0.819-1.102

0.844-0.891

CMC controller

    

Characteristics

Nominal

Δ=0.2

Δ=0.5

Δ=1.0

t r (s)

11,147

15,501

25,753

30,838

t s (s)

28,848

28,324

42,494

49,196

M OV (%)

2.84

13.12

26.25

56.37

e ss (M)

0.00

0.19

0.46

0.98

Parameters

Nominal

Δ=0.2

Δ=0.5

Δ=1.0

γ Sb1 (/s) [10 −3]

0.400

0.426-0.479

0.534-0.597

0.542-0.798

γ Sb2 (/s) [10 −3]

0.400

0.400-0.478

0.404-0.511

0.403-0.798

γ Sb3 (/s) [10 −3]

0.400

0.406-0.457

0.425-0.578

0.403-0.633

k b1 (/M/s) [10 −5]

0.550

0.567-0.644

0.577-0.808

0.619-1.075

k b2 (/s)

12.50

12.64-14.75

16.57-17.84

16.99-17.95

k b3 (/M/s) [10 −4]

0.180

0.182-0.207

0.203-0.238

0.196-0.274

k b4 (/s)

140.00

144.48-163.09

165.38-205.25

143.15-278.30

k r1 (/M/s) [10 −4]

0.500

0.503-0.593

0.523-0.712

0.538-0.807

k r2 (/s)

1.600

1.635-1.893

1.839-1.950

1.789-2.861

k r2 (/s) [10 −3]

0.800

0.803-0.943

0.804-1.162

0.808-1.525