Fig. 5
Effect of 8 nm PAA-coated gold NPs on Aβ1–40 monomer aggregation. Aβ1-40 monomer diluted to 40 μM in 40 mM Tris–HCl (pH 8.0) was aggregated alone (control, Ο) or in the presence of 8 nm PAA-coated NPs at concentrations of 200 pM (▶), 100 pM (
), or 20 pM (
). Monomer aggregation was induced by continuous agitation and monitored periodically via ThT fluorescence. ThT fluorescence and time values are presented as in Fig. 3. Results are representative of 3 independent experiments