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Table 2 Synergistic effect between SDF-1α and other bioactive factors

From: Delivery of stromal cell-derived factor 1α for in situ tissue regeneration

Bonding strategy Factors Implant position Scaffold References
Direct loading or adsorption
(Adsorb solution through inject)
SDF-1α and BMP-2 Mouse, calvarial defects Commercial collagena [94]
Gelatin hydrogels [95]
Direct loading or adsorption
(Direct loading during manufacture process)
Mouse, ulna critical-sized defect Degradable hydrogels [96]
Mouse, calvarial defects/ subcutaneous sites Commercial collagenb [97]
SDF-1α and VEGF Mouse, calvarial defects/ subcutaneous sites Commercial collagenb [97]
SDF-1α and platelet-derived growth factor (PDGF) Mouse, calvarial defects/ subcutaneous sites Commercial collagenb [97]
SDF-1α and simvastatin Mouse, calvarial defects PLGA [117]
SDF-1α and insulin-like growth factor-1 (IGF-1) Rat, lateral gastrocnemius muscle of the TK-injured limb PEGylated fibrin gel matrix [98]
  1. aResorbable atelocollagen sponges (Teruplug; Terudermis Olympus Terumo Biomaterials Co.)
  2. bCollagen scaffold (Geistlich Pharma AG)