Fig. 4

Deficient photoentrainment & and increased basal locomotor activity in LAB mice. a Actogram of CD1 animals (mean values only, 1h bin). White background indicates housing lights ON; gray background indicates housing lights OFF. On day 3 the light cycle was shifted -6 h, by shortening the dark period. b Actogram of LAB animals. c Overlaid actograms of CD1 (black, dashed line) and LAB (blue, solid line) with the respective SEM ranges. Colored boxes (bottom) A red, B orange, C green, indicate the three different time points which have been analyzed separately (see e–g). d Overall averaged activity of CD1 (black) and LAB (blue) mice. Inset b indicates the baseline recording; c indicates the light cycle change. e Activity at time point A (2 AM – 8 AM), part of the dark period after day 3. f Activity at time point B (8 AM – 2 PM). g Activity at time point C (2 PM – 8 PM), part of the light period after day 3. h Modulation of locomotor activity by changes in light cycle. The individual activity of the first 3h after a light cycle change, was normalized to the activity 3h before the change in order to dissect the % modulation. The arrow indicates the absence of any modulation in LAB animals. Asterisks (*) indicates 1-way ANOVA, Dunnett’s Multiple Comparison Test compared to averaged baseline: ** p = <0.01. Hash (#) indicates 2-way ANOVA significance values as either strain (bracket) or time differences with Bonferroni post-hoc: # p = <0.05, ### p = <0.0001. Day 3 (light cycle change, indicated by ’c’) has been excluded from statistical analysis