Fig. 2
From: Engineered In Vitro Models of Tumor Dormancy and Reactivation
Modes of dormancy induction. Engineered, in vitro models of tumor dormancy can be classified based on the mode of dormancy induction: drug-induced dormancy (selective elimination and survival of sub-populations under chemotherapeutic treatment), ECM-induced dormancy (biophysical constraints imposed on cancer cells by the surrounding matrix), cell-signaling induced dormancy (paracrine signaling from stromal cells and vasculature) and biochemical-induced dormancy (influence of soluble factors, hypoxia and nutrients)