Fig. 4
From: Engineered In Vitro Models of Tumor Dormancy and Reactivation
Factors influencing reactivation of dormant cancer cells. Dormant tumor cells in the secondary niche can be stimulated or triggered toward metastatic growth via multiple sources including pro-inflammatory and angiogenic factors, paracrine signaling by stromal cells and sprouting vasculature, and dysregulated cell-matrix interactions amongst others