Fig. 1

Multiple areas of medicine and disease pathologies could benefit from advances in lymphatic tissue engineering. These include rescuing cardiac tissue after MI, clearing macromolecules from the brain to slow or hinder the onset of Alzheimer's disease, further understanding the pathways of cancer metastasis in order to effectively target cancer progression, designing improved organoids which would more accurately model native tissue, simulating lymphedema as an experimental model that could be used to design treatments for lymphedema beyond mechanical pumping, screening potential therapeutic agents to understand how they impact and interact with the lymphatic system, engineering superior skin grafts that incorporate the dermis and associated functionality, and promoting wound healing