Fig. 2

During vasculogenesis angioblasts assemble into primitive capillary plexus, which can further differentiate into either arteries through Ephrin B4 signaling or veins through Neuropilin, Notch, and Ephrin B2 signaling. Platelet aggregation in cardinal vein allows lymphangiogenesis to occur. A gradient of signaling molecules such as VEGF-C, signals the for the for LEC differentiation and migration, forming the primary lymphatic plexus. The lymphatic plexus begins to sprout and mature into lymphatic vessels