Table 5 The existence of various miRNAs with pro- and anti-angiogenesis capacity

miRNA-17-92

Promotes angiogenesis by modulation of connective tissue growth factor, thrombospondin-1, and integrin α5

[159]

miRNA-92a

Has a dual pro- and anti-angiogenic role

[160]

miRNA-21

Increases VEGF level and promotes angiogenesis through a STAT3-dependent mechanism

[161]

miRNA-494

Suppresses PTEN and activates Akt/eNOS pathway

[162]

miR-135b in exosomes from hypoxic multiple myeloma cells

Reduces the expression of FIH-1 and increased activity of HIF-1α

[163]

miR-125a

Promotes angiogenesis by inhibiting DLL-4

[92]