Fig. 2
From: Human three-dimensional in vitro model of hepatic zonation to predict zonal hepatotoxicity
Cell viability of HepaRG cells treated with four hepatotoxic drugs after CHIR pretreatment. The hepatotoxic drugs tamoxifen, isoniazid, bromobenzene, and APAP were administered to HepaRG cells pretreated with CHIR for 3 days. After 3 days of hepatotoxic drug treatment, the cell viability of HepaRG cells was measured using the CCK-8 assay, and the dose-response curve was analysed using GraphPad Prism software