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Table 2 Biotin optimization for biliverdin production in C. glutamicum BV004

From: Systems metabolic engineering of Corynebacterium glutamicum for the bioproduction of biliverdin via protoporphyrin independent pathway

Biotin concentration
(μg/L)
Cell biomass
(OD600)
Biliverdin
(mg/L)
Biliverdin/cell biomass (OD600)
1 40.12 ± 0.22 5.17 ± 1.29 0.13
5 49.80 ± 0.63 7.97 ± 0.33 0.16
20 55.41 ± 0.58 9.88 ± 0.38 0.18
50 55.79 ± 1.11 8.66 ± 0.48 0.16
100 54.00 ± 0.92 7.68 ± 0.61 0.14
200 55.10 ± 0.90 11.38 ± 0.47 0.21
300 59.30 ± 0.92 9.79 ± 0.77 0.17
500 58.93 ± 1.91 8.95 ± 1.46 0.15
  1. C. glutamicum BV004 were fermented at 150 rpm for 60 h with 40 g/L initial glucose as a sole carbon source. Results are the means ± standard deviations in three individual experiments