Fig. 4

3D structure of mutant protein I188K/S19C/G24C (a) and interaction with cefquinome (b). a The 3D structure of BlaR-CTD was represented as a cartoon, with α-helices colored in cyan, β-strands in magenta, and loops in salmon. The mutational sites of I188K, S19C and G24C were colored in yellow. b The AA residues involved in the interaction of protein with cefquinome. The hydrogen bonds were represented as black dotted lines. The cefquinome molecule was colored in gray. The AAs of the mutational sites were colored in yellow