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Fig. 1 | Journal of Biological Engineering

Fig. 1

From: Intestinal probiotics E. coli Nissle 1917 as a targeted vehicle for delivery of p53 and Tum-5 to solid tumors for cancer therapy

Fig. 1

EcN (Tum 5-p53) probiotics for cancer therapy. The engineered bacteria (purple) can specially accumulate in tumor areas of BALB/c mice bearing SMMC-7721 tumor after intravenous injection. The recombinant protein could be cleaved by matrix metalloproteinases that were highly expressed in the tumor regions, thereby inhibiting the growth of tumor cells through different anti-tumor mechanisms

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Journal of Biological Engineering

ISSN: 1754-1611