Fig. 9

Results of a deterministic simulations performed on the AC-DC circuit model. Blue, red and green represent the concentration of proteins X, Y and Z, respectively. The duration of simulation is 48 h with the initial conditions X=37nM, Y=280nM, Z=280nM. Figure (a) shows the bistable dynamics for a point in the parameter space α=5.91h⁻¹,n=4.16,β=47.35h⁻¹,δ_m=0.63h⁻¹,δ_p=1.12h⁻¹,Kd_a=165.03nM, Kd_b=111.2nM, Kd_c=101.5nM, Kd_d=0.48nM. The initial concentration of protein X is low and Y is high. Through time the concentrations of proteins X and Y balanced at 0 and 400 nM, respectively. Figure (b) shows the oscillating dynamics for the parameter point α=26.26h⁻¹,n=3.82,β=18.14h⁻¹,δ_m=0.92h⁻¹,δ_p=1.29h⁻¹,Kd_a=151.42nM, Kd_b=197.61nM, Kd_c=41.88nM, Kd_d=11.7nM. Proteins X and Z have the same amplitude of 200 nM, while the amplitude of protein Y is around 80 nM. All proteins have the same period of 12 hours