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Table 1 The top 10 differentially expressed genes when comparing urban particulate matter treatment and the untreated control group

From: Identification of urban particulate matter-induced disruption of human respiratory mucosa integrity using whole transcriptome analysis and organ-on-a chip

Gene symbolDescriptionRNA fold-changeP-value
Upregulated genes
MT1Hmetallothionein 1H16.130.0004
IL13RA2interleukin 13 receptor subunit alpha 214.920.009
MMP1matrix metallopeptidase 114.310.008
LCE3Dlate cornified envelope 3D14.170.034
IL1R2interleukin 1 receptor type 213.790.03
MT1Gmetallothionein 1G13.390.0001
CXCL8C-X-C motif chemokine ligand 811.200.020
SERPINB2serpin family B member 29.440.0008
CYP1A1cytochrome P450 family 1 subfamily A member 18.970.002
IL1RL1Interleukin 1 receptor-like 18.000.008
Downregulated genes
CALML3calmodulin like 3−5.460.008
SESN3sestrin 3−4.820.0002
ID3inhibitor of DNA binding 3, HLH protein−4.310.013
AKR1B10aldo-keto reductase family 1 member B10− 3.860.013
LFNGLFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase−3.860.003
TREM2triggering receptor expressed on myeloid cells 2−3.830.002
HSD17B3hydroxysteroid 17-beta dehydrogenase 3−3.700.009
TP53AIP1tumor protein p53 regulated apoptosis inducing protein 1−3.640.006
SYT8synaptotagmin 8−3.590.022