Table 1 The top 10 differentially expressed genes when comparing urban particulate matter treatment and the untreated control group
Gene symbol | Description | RNA fold-change | P-value |
|---|---|---|---|
Upregulated genes | |||
 MT1H | metallothionein 1H | 16.13 | 0.0004 |
 IL13RA2 | interleukin 13 receptor subunit alpha 2 | 14.92 | 0.009 |
 MMP1 | matrix metallopeptidase 1 | 14.31 | 0.008 |
 LCE3D | late cornified envelope 3D | 14.17 | 0.034 |
 IL1R2 | interleukin 1 receptor type 2 | 13.79 | 0.03 |
 MT1G | metallothionein 1G | 13.39 | 0.0001 |
 CXCL8 | C-X-C motif chemokine ligand 8 | 11.20 | 0.020 |
 SERPINB2 | serpin family B member 2 | 9.44 | 0.0008 |
 CYP1A1 | cytochrome P450 family 1 subfamily A member 1 | 8.97 | 0.002 |
 IL1RL1 | Interleukin 1 receptor-like 1 | 8.00 | 0.008 |
Downregulated genes | |||
 CALML3 | calmodulin like 3 | −5.46 | 0.008 |
 SESN3 | sestrin 3 | −4.82 | 0.0002 |
 ID3 | inhibitor of DNA binding 3, HLH protein | −4.31 | 0.013 |
 PALMD | palmdelphin | −3.94 | 0.012 |
 AKR1B10 | aldo-keto reductase family 1 member B10 | − 3.86 | 0.013 |
 LFNG | LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase | −3.86 | 0.003 |
 TREM2 | triggering receptor expressed on myeloid cells 2 | −3.83 | 0.002 |
 HSD17B3 | hydroxysteroid 17-beta dehydrogenase 3 | −3.70 | 0.009 |
 TP53AIP1 | tumor protein p53 regulated apoptosis inducing protein 1 | −3.64 | 0.006 |
 SYT8 | synaptotagmin 8 | −3.59 | 0.022 |