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Table 3 Statistical analyses of extracellular vesicle mRNA markers in clinical samples

From: Signature mRNA markers in extracellular vesicles for the accurate diagnosis of colorectal cancer

Biomarker(s)nCut-offaAUCSensitivity (%)Specificity (%)Accuracy (%)
MYC12.720.564010060
VEGF16.760.78808080
CDX21NANANANANA
CD13311.2750.868010087
CEA1NANANANANA
CK1914.850.544010060
EpCAM1NANANANANA
CD2413.060.63508060
VEGF+CK1928.3050.941008093
VEGF+CD24210.190.941008093
CK19 + CD24218.560.614010060
Signatureb27.190.961008093
Signature+CK1939.490.961008093
Signature+CD24310.520.961008093
Signature+CK19 + CD24438.860.918010080
  1. Note: a Cut-off value was calculated using Youden’s index, which maximizes the sum of sensitivity and specificity; b Combined marker of VEGF and CD133; n number of biomarker(s); AUC area under the curve; NA not applicable