Table 3 Statistical analyses of extracellular vesicle mRNA markers in clinical samples
From: Signature mRNA markers in extracellular vesicles for the accurate diagnosis of colorectal cancer
Biomarker(s) | n | Cut-offa | AUC | Sensitivity (%) | Specificity (%) | Accuracy (%) |
|---|---|---|---|---|---|---|
MYC | 1 | 2.72 | 0.56 | 40 | 100 | 60 |
VEGF | 1 | 6.76 | 0.78 | 80 | 80 | 80 |
CDX2 | 1 | NA | NA | NA | NA | NA |
CD133 | 1 | 1.275 | 0.86 | 80 | 100 | 87 |
CEA | 1 | NA | NA | NA | NA | NA |
CK19 | 1 | 4.85 | 0.54 | 40 | 100 | 60 |
EpCAM | 1 | NA | NA | NA | NA | NA |
CD24 | 1 | 3.06 | 0.63 | 50 | 80 | 60 |
VEGF+CK19 | 2 | 8.305 | 0.94 | 100 | 80 | 93 |
VEGF+CD24 | 2 | 10.19 | 0.94 | 100 | 80 | 93 |
CK19 + CD24 | 2 | 18.56 | 0.61 | 40 | 100 | 60 |
Signatureb | 2 | 7.19 | 0.96 | 100 | 80 | 93 |
Signature+CK19 | 3 | 9.49 | 0.96 | 100 | 80 | 93 |
Signature+CD24 | 3 | 10.52 | 0.96 | 100 | 80 | 93 |
Signature+CK19 + CD24 | 4 | 38.86 | 0.91 | 80 | 100 | 80 |