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Fig. 3 | Journal of Biological Engineering

Fig. 3

From: Pathophysiology of mesangial expansion in diabetic nephropathy: mesangial structure, glomerular biomechanics, and biochemical signaling and regulation

Fig. 3

The role of the mesangial matrix in regulating mesangial cell phenotype, proliferation, and collagen accumulation. Structural and compositional alterations to the mesangial matrix cause the activation of the mesangial cell, which enhances proliferation and collagen I production. TGF- β production by the activated mesangial cell causes mesangial cell hypertrophy and prevention of mesangial cell proliferation. MC: mesangial cell, MM: mesangial matrix, TGF- β: transforming growth factor beta. Pointed arrows represent enhancement, and flathead arrows indicate inhibition

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Journal of Biological Engineering

ISSN: 1754-1611