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Table 4 The role of matrix structure and composition in regulating mesangial cell behavior. Bm: basement membrane. Elongated cell shape indicates activated phenotype of mesangial cell, while a stellate shape would have indicated quiescent phenotype. Extended cell shape description is an ambiguous descriptor. Diseased matrix is an aligned matrix scaffold, whereas a normal matrix is a nonaligned matrix scaffold

From: Pathophysiology of mesangial expansion in diabetic nephropathy: mesangial structure, glomerular biomechanics, and biochemical signaling and regulation

Matrix type

Diseased matrix [71]

Collagen I matrix [69]

Collagen I matrix [70]

Control

Normal matrix

Bm matrix

Bm matrix

Cell shape

elongated

extended

elongated

Proliferation rate

↑

↑

↑

Migration rate

-

↑

↑

α-sma expression

↑

-

-

Collagen IV expression

↓

-

-

Collagen I expression

↑

-

-

TGF- β expression

↑

-

-