Fig. 1

ELF3 correlates with an epithelial phenotype. A Scatterplot showing the correlation coefficients of individual genes with epithelial and mesenchymal scores across the CCLE cohort. Mesenchymal genes VIM, ZEB1, SNAI1 and SNAI2 are represented in blue and epithelial genes GRHL2, OVOL2, KLF4 and CDH1 are represented in orange. ELF3 is represented in red. B Tissue specific correlations of ELF3 with epithelial and mesenchymal scores in the CCLE cohort when grouped by tissue of origin. C Correlations of ELF3 with epithelial and mesenchymal scores across different TCGA cancer types. D Boxplot showing ELF3 expression levels across different cancer types in TCGA. Cancer types are ordered by increasing median epithelial scores. E Changes in ELF3 expression during EMT and/or MET induction across GEO datasets. I GSE118407 ii) GSE61220 iii) GSE58252 iv) GSE59922. *: p < 0.05 (Students’ t-test)