Fig. 4
ELF3 as a MET inducer. A PCA scatter plot of all steady states of RACIPE colored by (i) EMT score (= ZEB – miR200), ii) SLUG levels iii) ELF3 levels and iv) KLF4 levels. B Scatterplot of EMT scores and ELF3 levels across steady state solutions obtained from RACIPE. Spearman correlation coefficient and p-value are mentioned. C Fraction of steady state solutions resulting in Epithelial phenotype in control, 20-fold and 100-fold over expression of ELF3. * represents a statistically significant difference in the fraction of cases in the epithelial phenotype (Students’ t-test; p < 0.05). D Volcano plots showing correlation of ELF3 and KLF4 levels with ssGSEA epithelial and mesenchymal scores in a meta-analysis of breast cancer datasets. Each dot represents a dataset. R <—0.3, p < 0.05 or R > 0.3, p < 0.05 are counted as statistically significant cases. Nneg denotes number of datasets for which a negative correlation (blue dots) is observed, Npos denotes number of datasets for which a positive correlation (red dots) is observed between the two corresponding expression levels or ssGSEA scores