Fig. 2
From: Unravelling the mechanotransduction pathways in Alzheimer’s disease
Force transmission pathway from the ECM to the nuclear lamina. Extracellular matrix interacts with integrins that transduce the mechanical stimuli to the cytosolic F-actin through the plasma membrane. The F-actin microfilaments are connected to the nuclear lamina by the LINC complex, consisting of nesprins and SUN proteins. SUN proteins are directly connected to the nuclear lamina