From: Advances in the application of Mxene nanoparticles in wound healing
Mxenes | Type of models | Dose | Toxicity Effects | Reference |
---|---|---|---|---|
Ti3C2Tx | Zebrafish embryos | 25–200 µg mL− 1 | At the concentration of 50 µg mL− 1, no acutoxicity or neurotoxicity was observed. | [69] |
Ti3C2Tx | Chicken embryos | 30 µg per embryo,5 days incubation | Potential toxicity on the early stage of embryogenesis; down regulation of several controller genes of cell proliferation, survival, cell death and angiogenesis; inhibition of blood vessel development. | [70] |
Ti3C2Tx | rats | - | No obvious inflammatory and toxic side effects | [71] |
Ti3C2Tx | rats | - | excellent in vivo biosafety without damaging the main organs | [72] |
Ti3C2Tx | ICR mice | 20 mg kg− 1 | Ti3C2Tx nanosheets could accumulate in the liver and lungs. Those in the lung might influence respiratory function | [73] |
Nb2CTx | Kunming mice | 20 mg kg− 1 | No significant inflammation was caused. No significant histological abnormalities were found. | [27] |