Biological process | Number of gene | FDR | Genes |
---|---|---|---|
Positive regulation of ERK1 and ERK2 cascade | 56 | 2.62E-08 | ARHGAP8, FLT4, ITGB3, HTR2B, HTR2C, FGF2, CX3CL1, ICAM1, PYCARD, C1QTNF3, EDNRA, CYSLTR2, GLIPR2, CD36, LGALS9, NPY5R, DCC, IL1B, RARA, CHI3L1, CD44, CCL12, C5AR2, C5AR1, NOD2, C3, CCL9, THPO, GPNMB, CCL7, CCL6, ERBB4, NPY, PDGFD, CCL4, GCNT2, CCL3, CCL2, CCL19, NTSR2, CCR1, JUN, CCL22, TGFB1, CCL20, CFLAR, SCIMP, MT3, ESR1, EPOR, IL6, GPR183, TRPV4, FGF18, F2RL1 |
Positive regulation of MAPK cascade | 38 | 1.04E-06 | ITGB1, CD40, ITGB3, FLT4, TNFRSF11B, NOD2, KNG2, KNG1, LEPR, RIPK1, CD36, RELT, IL6R, NTSR2, TBX1, NGFR, IL11, GPR37, KSR1, IGFBP3, PRKCD, OSM, IGF2, LIF, GPR37L1, IGF1, TNFRSF1B, SORBS3, AGT, AR, IL6, PTPRC, ADRB3, FAS, CD27, LTBR, TNFRSF26, FGFR1 |
Cellular response to tumor necrosis factor | 41 | 3.59E-06 | REG3B, CCL12, CD40, CALCA, THBS1, CX3CL1, ICAM1, PYCARD, ZFP36, CCL9, ADAMTS13, MUC2, CCL7, CCL6, CCL4, ZC3H12A, CCL3, CCL2, CYP1B1, HAS2, RIPK1, CCL19, ADAMTS7, VCAM1, CCL22, NOS2, NOS3, CCL20, ERBIN, ACOD1, CYBA, MMP9, OCLN, IL6, FABP4, IRF1, GPD1, LCN2, FAS, CHI3L1, BIRC3 |
Integrin-mediated signaling pathway | 27 | 6.25E-04 | ITGB1, LAMA5, ITGAM, ITGB3, PLEK, ITGB2, ITGAL, PRAM1, ADAMTS2, ADAMTS1, ITGAX, ITGB8, ITGB7, ADAMTS9, FCER1G, ITGA2, ITGA1, ADAM11, VAV1, FGR, COL3A1, TYROBP, ZYX, PLP1, ITGA5, CDH17, FERMT3 |
Positive regulation of protein kinase B signaling | 26 | 0.0012 | CSF3, TNF, THBS1, FGF2, C1QTNF3, THPO, CCL3, CPNE1, GCNT2, CCL19, NGFR, TGFB1, MYOC, F10, IGF2, IGF1, F3, F7, IL6, MC1R, RARA, CD28, HCLS1, CHI3L1, HBEGF |
Positive regulation of I-kappaB kinase/NF-kappaB signaling | 38 | 0.0016 | CD40, ECM1, EDA, HTR2B, NOD2, ZC3HAV1, TNF, LITAF, MALT1, GJA1, LGALS1, CASP8, S100A13, TNFSF10, HMOX1, FLNA, RIPK1, CD36, LGALS9, CCL19, TGM2, SECTM1B, NEK6, IRAK4, CFLAR, TICAM1, RHOC, TNFRSF1A, GPRC5B, TNIP2, CTH, IL1B, REL, F2RL1, S100A4, LTBR, MYD88, CARD11 |
Response to tumor necrosis factor | 15 | 0.0020 | NOS2, GCH1, MMP3, PTGS2, MMP9, CXCL16, ADAMTS13, CASP8, CHI3L1, CCL2, RIPK1, MBP, CD14, JAK2, GGT1 |
Intracellular signal transduction | 74 | 0.0021 | ITK, GUCY1B2, MAST3, DGKB, PLEK, HSPB1, PREX2, NRBP2, ZFP36, GRB14, CASP3, STK32A, JAK2, JAK3, GUCY1A2, CISH, PRKCD, MASTL, DGKZ, LAX1, VAV1, TIAM2, LAT2, ZAP70, DEPDC1B, MELK, TYROBP, RASA4, NRG4, SPATA13, DCX, ARHGEF2, PLCB1, SHC4, LOC100911548, GUCY2D, RGS14, SHC1, ADCY4, ASB11, NOD2, KALRN, ADCY7, RGD1562638, SOCS3, NUAK2, SOCS1, IRAK2, CHN2, CHN1, HMOX1, PLEK2, SH2B2, SOCS4, LYN, NOS2, MCF2, ECEL1, DCLK3, DCDC2, SMAD7, MOS, ADCY10, SPSB2, SPSB1, MC1R, CAMK4, STAC2, GPR182, PTPN6, PLCH2, ASB2, PLCD4, PLCD1 |
Tumor necrosis factor-mediated signaling pathway | 16 | 0.0024 | TNFSF18, NGFR, CD40, TNFRSF10B, TNFRSF11B, TNFRSF1B, TNF, TNFRSF1A, PYCARD, FAS, CD27, LTBR, TNFRSF26, JAK2, RELT, CARD14 |
Cell surface receptor signaling pathway | 44 | 0.0024 | CD63, CD274, LOC103690020, VIPR1, VIPR2, TNFRSF13B, GIPR, ITGAL, MCHR1, ADGRG3, GHRHR, UPK1B, ADGRG5, CXCR2, PRLHR, CD36, FCGR1A, CD53, LAG3, FCER1G, ANXA1, ADGRV1, TRPA1, EDN3, NPY5R, GCGR, GLP2R, TACR1, F2, TNFRSF1B, AGT, TNFRSF1A, ADGRF2, FCGR2A, MAPKAPK3, CD8A, CLCF1, TSPAN18, ADGRF4, COL4A3, CD9, OSTN, FCGR2B, MYD88 |
Positive regulation of tumor necrosis factor production | 19 | 0.0039 | FCER1G, CYBA, NOD2, TICAM1, NFATC4, TNFRSF1A, PYCARD, CCL4, CCL3, CCL2, RIPK1, CD36, LGALS9, CCL19, ARHGEF2, LBP, CD14, JAK2, MYD88 |
Positive regulation of NF-kappaB transcription factor activity | 30 | 0.0052 | CD40, EDA, ITGB2, CAMK2A, NOD2, TNF, MALT1, ICAM1, PYCARD, IRAK2, NLRP3, RIPK1, LGALS9, IL6R, TNFSF18, TGFB1, RIPK3, SPHK1, CFLAR, TICAM1, AR, IL6, CTH, IL1B, ARHGEF2, RAB7B, CARD14, MYD88, HSPA1B, CARD11 |
Adenylate cyclase-activating G-protein coupled receptor signaling pathway | 18 | 0.0090 | PTGFR, PTGIR, CALCA, GPR26, GCGR, PTGER2, PTGER3, ADCY4, ADRB1, HTR4, ADCY7, RXFP1, RXFP2, GHRHR, ADRB3, GALR2, UCN2, ADM2 |
Phospholipase C-activating G-protein coupled receptor signaling pathway | 19 | 0.010 | CASR, C5AR2, PTGER3, C5AR1, HTR2B, HTR2C, GPR84, ESR1, AGTR1A, GNG13, ANO1, CYSLTR2, GALR2, P2RY2, CXCR2, C3AR1, PLCE1, TGM2, NTSR2 |
Positive regulation of phosphatidylinositol 3-kinase signaling | 19 | 0.019 | CSF3, TGFB2, MYOC, IGF1, F2, AGT, FGR, SELP, GH1, ERBB4, PDGFD, RARA, CD28, F2RL1, HCLS1, PLXNB1, PTPN6, JAK2, HCST |
Lipopolysaccharide-mediated signaling pathway | 12 | 0.028 | LYN, TGFB1, IRAK2, NOS3, IL1B, CCL3, CCL2, LBP, CD14, TICAM1, TNF, MYD88 |