Biological process | Number of gene | FDR | Genes |
---|---|---|---|
Inflammatory response | 106 | 6.03E-23 | NCF1, TRIL, TNF, NPPB, PYCARD, ZC3H12A, C3AR1, LGALS9, MAP2K3, IL4R, SLC11A1, CYBB, CYBA, NAIP6, CD8A, S100A8, PTGFR, CALCA, C5AR2, C5AR1, TNFRSF11B, MEFV, KNG2, KNG1, C3, IRAK2, NLRP3, CD14, CCR1, NGFR, SMAD1, TGFB1, TNFRSF10B, CELA1, SERPINA3N, SELE, NFKB2, SELP, CXCL10, CXCL11, IL6, CXCL12, REL, CD27, SDC1, MYD88, TP73, CXCL6, CD40, ECM1, CXCL9, SERPINA1, CXCL1, CXCL3, CXCL2, CX3CL1, CASP4, NFKBIZ, OLR1, CCR7, PTGIR, ANXA1, SPHK1, TNFRSF1B, NGF, AGTR1A, TNFRSF1A, HCK, GAL, IL1B, CHI3L1, TLR10, TNFRSF26, CD44, TLR13, CCL12, PTGER2, PTGER3, PTGS2, THBS1, PTGS1, RELB, CCL9, CCL7, CNR2, DDT, CCL6, PDPN, CCL4, SPP1, CCL3, CCL2, S1PR3, CCL19, RELT, KCNJ10, CCL22, NOS2, CCL20, KRT16, CAMK4, PLP1, FAS, F2RL1, ACKR2, LTBR |
Neutrophil chemotaxis | 33 | 4.09E-12 | CCL12, CSF3R, ITGAM, C5AR1, ITGB2, CXCL1, TREM3, CXCL3, TREM1, CXCL2, CX3CL1, LGALS3, CCL9, CCL7, CCL6, CXCR2, CCL4, CCL3, SPP1, PDE4B, CCL2, CCL19, TGFB2, FCER1G, CCL22, EDN3, CCL20, ITGA1, VAV1, FCGR2A, IL1B, S100A9, S100A8 |
Immune response | 74 | 3.42E-09 | CXCL6, CSF3, CXCL9, EDA, LST1, CXCL1, CXCL3, TNF, CXCL2, CX3CL1, FCAR, TNFSF13B, VPREB3, ENDOU, ENPP2, TNFSF10, CCR7, CD36, ENPP3, SECTM1B, SBSPON, IL4R, RT1-CE4, RT1-CE5, TNFRSF1B, LAX1, RT1-CE3, VAV1, TNFRSF1A, ZAP70, PLSCR1, SLPI, IL1B, IRF8, TNFRSF26, RT1-CE10, C1QB, CD274, LOC103690020, CXCR5, OAS1A, RT1-A1, TNFRSF11B, RT1-A2, THBS1, OAS1F, VTN, C6, NFIL3, CCL4, RELT, CCR1, NGFR, CCL22, RT1-DMB, ZFR2, TNFSF15, TNFSF13, LIF, OSM, TNFRSF10B, PRG4, CXCL10, CXCL11, CXCL12, CD28, TNFSF9, FAS, CD27, TNFSF8, LTBR, FCGR2B, CD244, RT1-T24-4 |
Cellular response to interleukin-1 | 39 | 5.65E-09 | CCL12, CD40, CEBPB, PTGER3, SERPINE1, HIF1A, CXCL2, CX3CL1, ICAM1, PYCARD, CCL9, CCL7, CCL6, MYC, P2RY2, CCL4, ZC3H12A, CCL3, CCL2, HAS2, APOE, CCL19, ADAMTS7, CCL22, PTGIS, NOS2, CCL20, MMP3, FN1, PAWR, ACOD1, SERPINA3N, MMP9, PSMB9, IL6, IRF1, LCN2, FAS, CHI3L1 |
Positive regulation of inflammatory response | 29 | 3.37E-08 | CCL12, SERPINE1, TNF, ETS1, CX3CL1, HSPD1, CCL9, EDNRA, CCL7, CCL6, CCL4, CCL3, CCL2, JAK2, LDLR, TGM2, STAT5A, TNFSF18, ACE, ITGA2, PLA2G4A, IL17RB, TNFRSF1A, GPRC5B, FABP4, TRPV4, TLR10, S100A9, S100A8 |
Cytokine-mediated signaling pathway | 46 | 3.37E-08 | RTN4R, LRRC15, IL1RN, CSF3R, FLT3, LRRC4, IL20RB, CSF2RB, IL2RG, CX3CL1, SOCS3, DUOX1, IL1RL2, SOCS1, LRRTM3, LRRTM1, CCL2, JAK2, JAK3, IL6R, DUOX2, SH2B2, SOCS4, STAT5A, IL4R, CISH, IL10RB, IL1R1, IL1R2, BGN, IFNLR1, IRAK4, OSMR, F3, IL17RC, IL17RB, TNFRSF1A, EREG, KLF6, IL6, IL1B, IL2RB, IL7R, IL6ST, MYD88, CD44 |
Response to cytokine | 36 | 3.07E-07 | CD274, OXTR, SERPINA1, SERPINE1, PTGS2, CXCL16, RELB, SOCS3, SOCS1, ACP5, TIMP1, SKIL, IL6R, TIMP4, JUN, TGFB2, NOS3, STAT3, MMP3, SERPINA3N, OSMR, SELE, NFKB2, FOSL2, FOSL1, GH1, COL3A1, IL6, MAPKAPK3, RARA, REL, FAS, IL6ST, TP53, CFTR, PTGES |
Leukocyte cell–cell adhesion | 16 | 3.10E-06 | ITGB1, CALCA, VCAM1, ITGAM, ITGB2, MSN, ITGAL, SELE, ICAM1, SELP, NT5E, PTPRC, OLR1, ITGA5, EZR, FERMT3 |
Chemokine-mediated signaling pathway | 24 | 8.61E-06 | CCR1, CXCL6, CXCL9, CCL12, CCL22, CCL20, CXCR5, CXCR4, CXCL1, CXCL3, CXCL2, CX3CL1, CXCL10, CCL9, CXCL11, CXCL12, CCL7, CCL6, CXCR2, CCL4, CCL3, CCL2, ACKR2, CCL19 |
Chemotaxis | 25 | 2.01E-05 | CXCL9, C5AR2, C5AR1, HMGB2, CXCR5, CXCR4, LSP1, CX3CL1, AMOT, C3, CXCR2, CCL3, ENPP2, S1PR1, C3AR1, RAC2, PROK2, CCR7, CMKLR1, LYN, CCL20, CXCL10, CXCL11, FES, ACKR2 |
Acute-phase response | 18 | 6.83E-05 | REG3B, REG3A, IL1RN, SERPINA1, STAT3, HP, FN1, REG3G, F2, HIF1A, KNG1, SIGIRR, PLSCR1, IL6, TFR2, LBP, A2M, LOC100911545 |
Leukocyte migration | 17 | 9.63E-05 | B4GALT1, C5AR2, C5AR1, MSN, TNF, SELE, MMP9, ICAM1, SELP, SELL, PODXL, IL1B, C3AR1, PDE4B, F2RL1, ITGB7, CD34 |
Positive regulation of neutrophil chemotaxis | 14 | 1.53E-04 | C5AR1, CXCL1, CXCL3, CXCL2, THBS4, EDNRA, SELL, IL1B, CXCR2, C3AR1, RAC2, CCR7, CCL19, LBP |
Cellular response to interferon-gamma | 22 | 4.39E-04 | CCL12, CCL22, NOS2, CCL20, ACOD1, SERPINA3N, EPRS, CX3CL1, ICAM1, CCL9, ADAMTS13, CCL7, CCL6, MYC, CCL4, CCL3, CCL2, LGALS9, CCL19, LOC685067, GBP2, GBP1 |
Cellular response to cytokine stimulus | 18 | 5.96E-04 | STAT5A, CD86, CSF3, MME, NOS2, FLT3, STAT3, CXCR4, MMP9, PLSCR1, IL6, IL18RAP, SOCS1, DPYSL3, HCLS1, FAS, CCR7, JAK3 |
Monocyte chemotaxis | 15 | 6.93E-04 | CCL12, CALCA, ANXA1, CCL22, CCL20, CX3CL1, LGALS3, CCL9, CCL7, CCL6, CCL4, CCL3, CCL2, CCL19, FOLR2 |
Acute inflammatory response | 12 | 0.0020 | IL6, VCAM1, B4GALT1, IL1B, HP, DEFB1, CXCL1, TACR1, TNF, S100A8, ADRA2A, PTGES |
Negative regulation of inflammatory response | 25 | 0.0029 | TNFAIP6, MEFV, ETS1, C1QTNF3, SOCS3, ZFP36, NT5E, CNR2, PBK, ACP5, NLRP3, APOE, LGALS9, SLIT2, IER3, GHSR, PTGIS, ACOD1, TNFRSF1B, TNFRSF1A, SLPI, TYRO3, PTPN2, ADA, CD44 |
Regulation of inflammatory response | 20 | 0.0032 | LYN, ANXA1, IL1R1, NOD2, ESR1, AGT, PYCARD, IL1RL2, SBNO2, CASP12, FABP4, BCL6, DUOXA1, CASP4, ZYX, NLRP3, JAK2, GGT1, MGLL, MYD88 |
Cell chemotaxis | 20 | 0.0032 | CXCL6, CXCL9, CCL22, VCAM1, C5AR2, C5AR1, PRKCD, ARHGEF16, ITGA1, HMGB2, CXCL1, AGTR1A, CXCL12, CCL6, GPR183, CCL4, C3AR1, ENPP2, ENG, HBEGF |
Positive regulation of leukocyte migration | 11 | 0.0065 | SELP, TNFSF18, KITLG, CCL12, ITGB3, ITGA2, CCL2, TACR1, MMP9, SELE, TP53 |
Lymphocyte chemotaxis | 11 | 0.0065 | CCL9, CCL12, CCL22, CCL7, CCL20, CCL6, CCL4, CCL3, CCL2, CCL19, CX3CL1 |
Leukocyte chemotaxis | 9 | 0.0078 | CCR1, CNR2, GPR183, CCL4, CXCR5, S1PR1, CCL3, S100A9, CXCL2 |
Positive regulation of phagocytosis | 16 | 0.0088 | FCER1G, SLC11A1, PROS1, CYBA, NOD2, TNF, MYH9L1, PYCARD, C3, FCGR2A, IL1B, PTX3, CD36, FCGR1A, MFGE8, FCGR2B |
Positive regulation of interleukin-6 production | 17 | 0.0090 | FCER1G, CYBA, NOD2, TICAM1, TNF, HSPD1, PYCARD, IL1RL2, IL6, IL1B, TNFSF9, CD36, ARHGEF2, LBP, RAB7B, IL6R, MYD88 |
Receptor-mediated endocytosis | 25 | 0.022 | IFITM3, LOXL4, CXCL16, LOXL2, VTN, ENDOU, ENPP2, OLR1, APOE, ENPP3, CD14, FCGR1A, LDLR, SBSPON, MSR1, CD163, SCARA5, CD300A, PRG4, SSC5D, TMPRSS13, ADRB3, TFR2, ACKR2, FCGR2B |
Positive regulation of macrophage chemotaxis | 8 | 0.027 | TNFSF18, TRPV4, C5AR1, C3AR1, CCL2, THBS1, CX3CL1, CMKLR1 |
Positive regulation of phagocytosis, engulfment | 7 | 0.036 | ITGA2, F2RL1, PPARG, ANO6, CD36, LBP, FCGR1A |
Response to interleukin-1 | 14 | 0.038 | PCSK1, IL1RN, ANXA1, IL1R1, SPHK1, MMP3, CYBA, HNMT, ETS1, SELE, IRAK2, CHI3L1, LGALS9, MYD88 |
Positive regulation of leukocyte chemotaxis | 8 | 0.039 | CXCL10, F7, CXCL6, CXCL11, CXCL9, EDN3, CXCR2, F2RL1 |