Fig. 8
From: Optimizing the fabrication of a 3D high-resolution implant for neural stimulation
Ex-vivo retinal stimulation proof of concept. a) The conceptual implant is placed in a dish with Ringer’s medium. b) A fluorescence image of the isolated retina harvested from transgenic GCaMP6f-Thy1 rats mounted on the implant. Arrows point to the micro-wells. c) The same as in b with the focal plane adjusted to show the fluorescent RGCs and axons (arrows). d) Average fluorescence change in response to electrical stimulation with increasing current density. e) Average fluorescence change in response to electrical stimulation with increasing charge density per phase, indicating an activation threshold below 0.156 \(\frac{mC}{{cm}^{2}phase}.\)