Regulator | Function | Reference |
---|---|---|
VE-1 | A key component of the velvet complex; and is required for light-dependent transcription; adapt quickly to changes in light exposure by promoting the accumulation of VE-1 for the regulation of genes that participate in the biosynthesis of photoprotective pigments. | [64] |
VeA | VeA interacts with other regulatory proteins, such as VelB and LaeA, to form a trimeric complex that controls the expression of secondary metabolite biosynthetic genes, in the dark VeA is located mainly in the nuclei, under light VeA is found abundantly in the cytoplasm. | [52] |
VelB | Regulates the expression of several genes involved in the germination process, including the genes for the proteins involved in cell wall degradation. | [65] |
VosA | Regulates the expression of several genes involved in the germination process, including the genes for the proteins involved in cell wall degradation | [65] |
SUB1 | SUB1 not only exerts negative regulation on secondary metabolism as shown during sexual development, but also positively influences metabolite production on minimal medium. | [28] |
MadA and MadB | Regulate the mycelial and other asexual processes. | [18] |
WCC | The WCC activates downstream signaling pathways that control the expression of secondary metabolite biosynthetic genes. | [66] |
LaeA | Interacts with other regulatory proteins, such as VeA and VelB, to control the expression of secondary metabolite biosynthetic genes. controls VeA modification and protein levels and possesses additional developmental functions. | [67] |
CarS | A protein down-regulates many genes whose expression is up-regulated by light in wild strains, expression and activation of carotenogenesis by stress, participate in the regulation of genes with catalase domains. | |
VosA | Regulates the expression of several genes involved in the germination process, including the genes for the proteins involved in cell wall degradation. | [65] |
LreA | Repressing function of some SMs. | [69] |