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Fig. 4 | Journal of Biological Engineering

Fig. 4

From: Antler stem cell-derived exosomes promote regenerative wound healing via fibroblast-to-myofibroblast transition inhibition

Fig. 4

Effects of AnSC-exos on the structure and composition of collagen in model rats. A Histological sections of the healed skin stained with Masson. B Total collagen accounts in the healed skin on POD 14. C-E Relative mRNA levels of Collagen I and Collagen III, and their ratio on POD 14. F Total collagen counts in the healed skin on POD 28. G-I Relative mRNA levels of Collagen I and Collagen III, and their ratio on POD 28. Note: application of AnSC-exos reduced collagen abundance; and improved collagen structural composition, including higher expression of Collagen III genes (pro-regeneration) and lower expression of Collagen I genes (pro-scarring) in the wound healing. Mean ± SEM; *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001; n = 3

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Journal of Biological Engineering

ISSN: 1754-1611