Optimize the parameters for the synthesis by the ionic gelation technique, purification, and freeze-drying of chitosan-sodium tripolyphosphate nanoparticles for biomedical purposes

Table 3 Significance of the factors studied on the response variables

Variable	Model order	Lack of adjustment (p-value)	R²	R² adjusted	Optimal values (goal: minimize)
Particle size	2°	0.0782	99.50	99.40	Stirring rate = 500 rpm
					Drip time = 2 min
					pH = 4.6
PDI	2°	0.0952	93.13	92.10	Stirring rate = 500 rpm
					Drip time = 2 min
					pH = 5.5

ISSN: 1754-1611