Fig. 2
From: Structural and practical identifiability analysis in bioengineering: a beginner’s guide
Simplistic overview of practical identifiability analysis using the profile likelihood process. NLL: negative log likelihood. A Example model with parameter estimate. B Example model fitting to observed data. C Chi- squared (\({\chi }^{2}\)) distribution (orange) for the associated model. D Model simulation based on different values for \(a\). E Different negative loglikelihood values based on the different parameter estimates. F: profile likelihood of \(a\). Note that some tools will use \({\chi }^{2}\) and negative loglikelihood interchangeably for the profile likelihood plots. Each of the steps are explained below