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  1. Synthetic biology aims at engineering gene regulatory circuits to end with cells (re)programmed on purpose to implement novel functions or discover natural behaviors. However, one overlooked question is whethe...

    Authors: Roser Montagud-Martínez, Jordi Ventura, Rafael Ballesteros-Garrido, Arantxa Rosado and Guillermo Rodrigo

    Citation: Journal of Biological Engineering 2020 14:12

    Content type: Research

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  2. Liver metabolites are used to diagnose disease and examine drugs in clinical pharmacokinetics. Therefore, development of an in vitro assay system that reproduces liver metabolite recovery would provide importa...

    Authors: Astia Rizki-Safitri, Marie Shinohara, Minoru Tanaka and Yasuyuki Sakai

    Citation: Journal of Biological Engineering 2020 14:11

    Content type: Research

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  4. Low-magnitude mechanical stimulation (LMMS) may improve skeletal health. The objective of this research was to investigate the long-term residual effects of LMMS on bone health. 10-week old female mice were gi...

    Authors: Kyle A. Bodnyk, Kyle S. Kuchynsky, Megan Balgemann, Brooke Stephens and Richard T. Hart

    Citation: Journal of Biological Engineering 2020 14:9

    Content type: Research

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  5. Hydrogels are a three-dimensional and crosslinked network of hydrophilic polymers. They can absorb a large amount of water or biological fluids, which leads to their swelling while maintaining their 3D structu...

    Authors: Farhad Abasalizadeh, Sevil Vaghefi Moghaddam, Effat Alizadeh, Elahe akbari, Elmira Kashani, Seyyed Mohammad Bagher Fazljou, Mohammadali Torbati and Abolfazl Akbarzadeh

    Citation: Journal of Biological Engineering 2020 14:8

    Content type: Review

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  6. In current cancer spheroid culturing methods, the transfer and histological processing of specimens grown in 96-well plates is a time consuming process. A centrifugal fluidic device was developed and tested fo...

    Authors: Warren Weisler, Samuel Miller, Shaphan Jernigan, Gregory Buckner and Matthew Bryant

    Citation: Journal of Biological Engineering 2020 14:7

    Content type: Research

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  7. Demineralized bone matrix (DBM), an allograft bone processed to better expose osteoinductive factors such as bone morphogenetic proteins (BMPs), is increasingly used for clinical bone repair. However, more ext...

    Authors: Soyon Kim, Jiabing Fan, Chung-Sung Lee, Chen Chen, Ksenia Bubukina and Min Lee

    Citation: Journal of Biological Engineering 2020 14:6

    Content type: Research

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  8. An efficient biodegradation-strengthening approach was developed to improve penicillin G degradation from industrial bacterial residue in an expanded bed adsorption bioreactor (EBAB) is reported in this paper.

    Authors: Peng Wang, Chen Shen, Xiaochun Wang, Shouxin Liu, Luwei Li and Jinfeng Guo

    Citation: Journal of Biological Engineering 2020 14:5

    Content type: Research

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  10. Knowledge of glutamate excitotoxicity has increased substantially over the past few decades, with multiple proposed pathways involved in inflicting damage. We sought to develop a monosodium glutamate (MSG) exp...

    Authors: Rick Liao, Thomas R. Wood and Elizabeth Nance

    Citation: Journal of Biological Engineering 2020 14:3

    Content type: Research

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  12. Aptamers, single-stranded DNAs or RNAs, can be selected from a library containing random sequences using a method called Systematic Evolution of Ligands by EXponential Enrichment (SELEX). In SELEX, monitoring ...

    Authors: Qingxiu Liu, Wei Zhang, Siying Chen, Zhenjing Zhuang, Yi Zhang, Lingli Jiang and Jun Sheng LIN

    Citation: Journal of Biological Engineering 2020 14:1

    Content type: Research

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  13. Controlling of biofilms formation in numerous pathogenic bacteria is one of the most difficult tasks in the control of bacterial diseases. Plasma has attracted extensive attention due to their potential applic...

    Authors: Hyemi Seo, Jisoo Hong, Taeyeol Kim, Won ll Choi, Daekyung Sung and Eunpyo Moon

    Citation: Journal of Biological Engineering 2019 13:94

    Content type: Research

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  14. This paper introduces a new technique combining microdialysis with patch clamp to detect the changes in ATP (adenosine triphosphate) concentration in acupoints during acupuncture. The microdialysis probe was i...

    Authors: Yong Wu, Meng Huang, Ying Xia and Guanghong Ding

    Citation: Journal of Biological Engineering 2019 13:93

    Content type: Research

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  15. Synthetic biology heavily depends on rapid and simple techniques for DNA engineering, such as Ligase Cycling Reaction (LCR), Gibson assembly and Golden Gate assembly, all of which allow for fast, multi-fragmen...

    Authors: Stefano Vecchione and Georg Fritz

    Citation: Journal of Biological Engineering 2019 13:92

    Content type: Methodology

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  16. Transcription factor-based biosensors are useful tools for the detection of metabolites and industrially valuable molecules, and present many potential applications in biotechnology and biomedicine. However, t...

    Authors: Leopoldo F. M. Machado, Andrew Currin and Neil Dixon

    Citation: Journal of Biological Engineering 2019 13:91

    Content type: Research

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  17. The production of transgenic chicken cells holds great promise for several diverse areas, including developmental biology and biomedical research. To this end, site-specific gene integration has been an attrac...

    Authors: Long Xie, Juanjuan Sun, Lifen Mo, Tianpeng Xu, Qaisar Shahzad, Dongyang Chen, Wenhao Yang, Yuying Liao and Yangqing Lu

    Citation: Journal of Biological Engineering 2019 13:90

    Content type: Research

    Published on:

  18. With the inherent high density and durable preservation, DNA has been recently recognized as a distinguished medium to store enormous data over millennia. To overcome the limitations existing in a recently rep...

    Authors: Yixin Wang, Md Noor-A-Rahim, Jingyun Zhang, Erry Gunawan, Yong Liang Guan and Chueh Loo Poh

    Citation: Journal of Biological Engineering 2019 13:89

    Content type: Research

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  19. Exposure to air particulate matter (PM) is associated with various diseases in the human respiratory system. To date, most in vitro studies showing cellular responses to PM have been performed in cell culture ...

    Authors: Junhyoung Byun, Boa Song, Kyungwoo Lee, Byoungjae Kim, Hae Won Hwang, Myung-Ryul Ok, Hojeong Jeon, Kijeong Lee, Seung-Kuk Baek, Sang-Heon Kim, Seung Ja Oh and Tae Hoon Kim

    Citation: Journal of Biological Engineering 2019 13:88

    Content type: Research

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  20. As an emerging research area of artificial enzymes, nanozyme, the catalytic nanomaterials with enzyme-like characteristics, have attracted enormous attention in research. Here, a nanozyme probe has been realiz...

    Authors: Aiyun Li, Lin Long, Fengshou Liu, Jianbo Liu, Xiaochun Wu and Yinglu Ji

    Citation: Journal of Biological Engineering 2019 13:87

    Content type: Research

    Published on:

  21. Large gap healing is a difficult issue in the recovery of peripheral nerve injury. The present study provides in vivo trials of silicone rubber chambers filled with collagen containing IFN-γ or IL-4 to bridge ...

    Authors: Chien-Fu Liao, Chung-Chia Chen, Yu-Wen Lu, Chun-Hsu Yao, Jia-Horng Lin, Tzong-Der Way, Tse-Yen Yang and Yueh-Sheng Chen

    Citation: Journal of Biological Engineering 2019 13:86

    Content type: Research

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  22. Tissue engineering, as an interdisciplinary approach, is seeking to create tissues with optimal performance for clinical applications. Various factors, including cells, biomaterials, cell or tissue culture con...

    Authors: Azizeh Rahmani Del Bakhshayesh, Nahideh Asadi, Alireza Alihemmati, Hamid Tayefi Nasrabadi, Azadeh Montaseri, Soodabeh Davaran, Sepideh Saghati, Abolfazl Akbarzadeh and Ali Abedelahi

    Citation: Journal of Biological Engineering 2019 13:85

    Content type: Review

    Published on:

  23. The original version of this article [1] unfortunately included a typographical error to author Žiga Pušnik’s name.

    Authors: Žiga Pušnik, Miha Mraz, Nikolaj Zimic and Miha Moškon

    Citation: Journal of Biological Engineering 2019 13:84

    Content type: Correction

    Published on:

    The original article was published in Journal of Biological Engineering 2019 13:75

  24. Attention has recently increased in the application of electrospun fibers because of their putative capability to create nanoscale platforms toward tissue engineering. To some extent, electrospun fibers are ap...

    Authors: Sonia Fathi Karkan, Soodabeh Davaran, Reza Rahbarghazi, Roya Salehi and Abolfazl Akbarzadeh

    Citation: Journal of Biological Engineering 2019 13:83

    Content type: Review

    Published on:

  25. The intestinal epithelium is a major site of drug metabolism in the human body, possessing enterocytes that house brush border enzymes and phase I and II drug metabolizing enzymes (DMEs). The enterocytes are s...

    Authors: Jennifer E. Speer, Yuli Wang, John K. Fallon, Philip C. Smith and Nancy L. Allbritton

    Citation: Journal of Biological Engineering 2019 13:82

    Content type: Research

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  26. Inulinase can hydrolyze polyfructan into high-fructose syrups and fructoligosaccharides, which are widely used in food, the medical industry and the biorefinery of Jerusalem artichoke. In the present study, a rec...

    Authors: Junyan Ma, Qian Li, Haidong Tan, Hao Jiang, Kuikui Li, Lihua Zhang, Quan Shi and Heng Yin

    Citation: Journal of Biological Engineering 2019 13:81

    Content type: Research

    Published on:

  28. The main issue in cutaneous regeneration is to develop engineered scaffolds based on natural extracellular matrix to promote dynamics of skin progenitor cells and accelerate differentiation into mature keratin...

    Authors: Leila Mohammadzadeh, Reza Rahbarghazi, Roya Salehi and Mehrdad Mahkam

    Citation: Journal of Biological Engineering 2019 13:79

    Content type: Research

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  29. Influenza viruses cause hundreds of thousands of respiratory diseases worldwide each year, and vaccination is considered the most effective approach for preventing influenza annual epidemics or pandemics. Sinc...

    Authors: Chia-Chun Lai, Yu-Chieh Cheng, Pin-Wen Chen, Ting-Hui Lin, Tsai-Teng Tzeng, Chia-Chun Lu, Min-Shi Lee and Alan Yung-Chih Hu

    Citation: Journal of Biological Engineering 2019 13:78

    Content type: Research

    Published on:

  30. The baculovirus (BV) Autographa californica multiple nuclear polyhedrosis virus has been used in numerous protein expression systems because of its ability to infect insect cells and serves as a useful vaccinatio...

    Authors: Keigo Kondou, Tomoyuki Suzuki, Myint Oo Chang and Hiroshi Takaku

    Citation: Journal of Biological Engineering 2019 13:77

    Content type: Research

    Published on:

  31. The promise of biopharmaceuticals comprising one or more binding domains motivates the development of novel methods for de novo isolation and affinity maturation of virion-binding domains. Identifying avenues ...

    Authors: Pete Heinzelman, Alyssa Low, Rudo Simeon, Gus A. Wright and Zhilei Chen

    Citation: Journal of Biological Engineering 2019 13:76

    Content type: Research

    Published on:

  32. Gene regulatory networks with different topological and/or dynamical properties might exhibit similar behavior. System that is less perceptive for the perturbations of its internal and external factors should ...

    Authors: Žiga Pušnik, Miha Mraz, Nikolaj Zimic and Miha Moškon

    Citation: Journal of Biological Engineering 2019 13:75

    Content type: Methodology

    Published on:

    The Correction to this article has been published in Journal of Biological Engineering 2019 13:84

  33. Since their inception, human induced pluripotent stem cells (hiPSCs) have held much promise for pharmacological applications and cell-based therapies. However, their potential can only be realised if large num...

    Authors: Diogo E. S. Nogueira, Carlos A. V. Rodrigues, Marta S. Carvalho, Cláudia C. Miranda, Yas Hashimura, Sunghoon Jung, Brian Lee and Joaquim M. S. Cabral

    Citation: Journal of Biological Engineering 2019 13:74

    Content type: Research

    Published on:

  34. Jamming state transition has been used in literature to describe migrating-to-resting cell state transition during collective cell migration without proper rheological confirmation. Yield stress often has been...

    Authors: Ivana Pajic-Lijakovic and Milan Milivojevic

    Citation: Journal of Biological Engineering 2019 13:73

    Content type: Research

    Published on:

  35. The green algae balls (Aegagropila linnaei), known as Marimo, are large spherical colonies of live photosynthetic filaments, formed by rolling water currents in freshwater lakes. Photosynthesis therein produces g...

    Authors: Neil Phillips, Thomas C. Draper, Richard Mayne and Andrew Adamatzky

    Citation: Journal of Biological Engineering 2019 13:72

    Content type: Research

    Published on:

  36. MicroRNAs (miRNAs) are implicated in the progression of ischemic stroke (IS) and bone marrow-derived mesenchymal stem cells (BMSCs)-derived exosomes play a role in IS therapy. Herein we hypothesized that the B...

    Authors: Yiming Deng, Duanduan Chen, Feng Gao, Hong Lv, Guojun Zhang, Xuan Sun, Lian Liu, Dapeng Mo, Ning Ma, Ligang Song, Xiaochuan Huo, Tianyi Yan, Jingbo Zhang and Zhongrong Miao

    Citation: Journal of Biological Engineering 2019 13:71

    Content type: Research

    Published on:

  37. Whole cell biosensors provide a simple method for the detection of heavy metals. However, previous designs of them rely primarily on simulation of heavy metal resistance systems of bacteria.

    Authors: Mingzhang Guo, Ruoxi Du, Zixin Xie, Xiaoyun He, Kunlun Huang, Yunbo Luo and Wentao Xu

    Citation: Journal of Biological Engineering 2019 13:70

    Content type: Research

    Published on:

  38. Non-alcoholic fatty liver disease (NAFLD) begins as simple hepatic steatosis, but further progress to chronic liver diseases results in severe liver damage and hepatic failure. However, therapeutic options are...

    Authors: Jae-Sung Ryu, Minji Lee, Seon Ju Mun, Sin-Hyoung Hong, Ho-Joon Lee, Hyo-Suk Ahn, Kyung-Sook Chung, Gun-Hwa Kim and Myung Jin Son

    Citation: Journal of Biological Engineering 2019 13:69

    Content type: Research

    Published on:

  39. Mesenchymal stem cells (MSCs) show tremendous promise as a cell source for tissue engineering and regenerative medicine, and are understood to be mechanosensitive to external mechanical environments. In recent...

    Authors: Tasneem Bouzid, Eunju Kim, Brandon D. Riehl, Amir Monemian Esfahani, Jordan Rosenbohm, Ruiguo Yang, Bin Duan and Jung Yul Lim

    Citation: Journal of Biological Engineering 2019 13:68

    Content type: Review

    Published on:

  40. Neuromodulation of central and peripheral neural circuitry brings together neurobiologists and neural engineers to develop advanced neural interfaces to decode and recapitulate the information encoded in the n...

    Authors: Benjamin J. Seicol, Sebastian Bejarano, Nicholas Behnke and Liang Guo

    Citation: Journal of Biological Engineering 2019 13:67

    Content type: Review

    Published on:

  41. Endophytic microorganisms are a rich source of bioactive natural products. They are considered as promising biofertilizers and biocontrol agents due to their growth-promoting interactions with the host plants ...

    Authors: Ozkan Fidan and Jixun Zhan

    Citation: Journal of Biological Engineering 2019 13:66

    Content type: Research

    Published on:

  42. Creating designer molecules using a combination of select domains from polyketide synthases and/or nonribosomal peptide synthetases (NRPS) continues to be a synthetic goal. However, an incomplete understanding...

    Authors: Fuchao Xu, Russell Butler, Kyle May, Megi Rexhepaj, Dayu Yu, Jiachen Zi, Yi Chen, Yonghong Liang, Jia Zeng, Joan Hevel and Jixun Zhan

    Citation: Journal of Biological Engineering 2019 13:65

    Content type: Research

    Published on:

  43. Significant rise in concentration of saline wastewater entering the treatment plants has been resulting in many problems in the biological treatment processes. On the other hand, the specific conditions of phy...

    Authors: Mostafa Tizghadam Ghazani and Alireza Taghdisian

    Citation: Journal of Biological Engineering 2019 13:64

    Content type: Research

    Published on:

  46. Silk glands are used by silkworms to spin silk fibers for making their cocoons. These have recently been regarded as bioreactor hosts for the cost-effective production of other valuable exogenous proteins and ...

    Authors: Sheng Xu, Feng Wang, Yuancheng Wang, Riyuan Wang, Kai Hou, Chi Tian, Yanting Ji, Qianqian Yang, Ping Zhao and Qingyou Xia

    Citation: Journal of Biological Engineering 2019 13:61

    Content type: Research

    Published on:

  47. As a type of chronic autoimmune joint disease, rheumatoid arthritis (RA) is a disorder, characterized by a variety of physical symptoms as well as RA fibroblast-like synoviocyte (RA-FLS) proliferation. More re...

    Authors: Chun-Wang Zhang, Xia Wu, Dan Liu, Wei Zhou, Wei Tan, Yu-Xuan Fang, Yu Zhang, Yan-Qing Liu and Guo-Qing Li

    Citation: Journal of Biological Engineering 2019 13:60

    Content type: Research

    Published on:

  48. The production of recombinant proteins in mammalian cell lines is one of the most important areas in biopharmaceutical industry. Viral transcriptional promoters are widely used to express recombinant proteins ...

    Authors: Roberto A Zúñiga, Matías Gutiérrez-González, Norberto Collazo, Pablo Hérnan Sotelo, Carolina H Ribeiro, Claudia Altamirano, Carmen Lorenzo, Juan Carlos Aguillón and María Carmen Molina

    Citation: Journal of Biological Engineering 2019 13:59

    Content type: Research

    Published on:

  49. Traditional cancer therapies, such as surgery treatment, radiotherapy, and chemotherapy, often fail to completely eliminate tumor cells in an anaerobic microenvironment of tumor regions.

    Authors: Lian He, Huijun Yang, Jianli Tang, Zhudong Liu, Yiyan Chen, Binghua Lu, Haocheng He, Sijia Tang, Yunjun Sun, Fei Liu, Xuezhi Ding, Youming Zhang, Shengbiao Hu and Liqiu Xia

    Citation: Journal of Biological Engineering 2019 13:58

    Content type: Research

    Published on:

  50. The purpose of this review is to assess the state-of-the-art fabrication methods, advances in genome editing, and the use of machine learning to shape the prospective growth in cardiac tissue engineering. Thos...

    Authors: Anh H. Nguyen, Paul Marsh, Lauren Schmiess-Heine, Peter J. Burke, Abraham Lee, Juhyun Lee and Hung Cao

    Citation: Journal of Biological Engineering 2019 13:57

    Content type: Review

    Published on:

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  • ISSN: 1754-1611 (electronic)

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Journal of Biological Engineering

ISSN: 1754-1611