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  1. Content type: Research

    The adoptive transfer of human T cells or genetically-engineered T cells with cancer-targeting receptors has shown tremendous promise for eradicating tumors in clinical trials. The objective of this study was ...

    Authors: Jianfa Ou, Yingnan Si, Yawen Tang, Grace E. Salzer, Yun Lu, Seulhee Kim, Hongwei Qin, Lufang Zhou and Xiaoguang Liu

    Citation: Journal of Biological Engineering 2019 13:34

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  2. Content type: Research

    Glycine cleavage system (GCS) plays a key role in one-carbon (C1) metabolism related to the biosynthesis of a number of key intermediates with significance in both biomedicine and biotechnology. Despite extens...

    Authors: Xinyi Zhang, Mei Li, Yingying Xu, Jie Ren and An-Ping Zeng

    Citation: Journal of Biological Engineering 2019 13:32

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  3. Content type: Research

    Extracellular vesicles (EVs) are membrane-bound phospholipid vesicles actively secreted by all cells. As they carry specific markers expressed by their parental cells, EVs are utilized to identify specific cel...

    Authors: Kalishwaralal Kalimuthu, Woo Young Kwon and Ki Soo Park

    Citation: Journal of Biological Engineering 2019 13:31

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  4. Content type: Research

    Glycolate is an important α-hydroxy carboxylic acid widely used in industrial and consumer applications. The production of glycolate from glucose in Escherichia coli is generally carried out by glycolysis and gly...

    Authors: Kangjia Zhu, Guohui Li, Ren Wei, Yin Mao, Yunying Zhao, Aiyong He, Zhonghu Bai and Yu Deng

    Citation: Journal of Biological Engineering 2019 13:30

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  5. Content type: Review

    In vitro three-dimensional (3D) microengineered tissue models have been the recent focus of pathophysiological studies, particularly in the field of cardiovascular research. These models, as classified by 3D b...

    Authors: Jaimeson Veldhuizen, Raymond Q. Migrino and Mehdi Nikkhah

    Citation: Journal of Biological Engineering 2019 13:29

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  6. Content type: Research

    Biliverdin, a prospective recyclable antioxidant and one of the most important precursors for optogenetics, has received growing attention. Biliverdin is currently produced by oxidation of bilirubin from mamma...

    Authors: Jiho Seok, Young Jin Ko, Myeong-Eun Lee, Jeong Eun Hyeon and Sung Ok Han

    Citation: Journal of Biological Engineering 2019 13:28

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  7. Content type: Research

    Owing to the thermal instability and low affinity of BlaR-CTD to some β-lactams, the receptor assay based on BlaR-CTD is limited in the detection of abundant variety of drugs and the result is often unstable. ...

    Authors: Jianan Ning, Saeed Ahmed, Guyue Cheng, Ting Chen, Yulian Wang, Dapeng Peng and Zonghui Yuan

    Citation: Journal of Biological Engineering 2019 13:27

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  8. Content type: Review

    Capillaries within the microcirculation are essential for oxygen delivery and nutrient/waste exchange, among other critical functions. Microvascular bioengineering approaches have sought to recapitulate many k...

    Authors: Huaning Zhao and John C. Chappell

    Citation: Journal of Biological Engineering 2019 13:26

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  9. Content type: Research

    Equine mesenchymal stromal cells (MSCs) are increasingly investigated for their clinical therapeutic utility. Such cell-based treatments can require cell numbers in the millions or billions, with conventional ...

    Authors: Erin L. Roberts, Tiffany Dang, Sarah I. M. Lepage, Amir Hamed Alizadeh, Tylor Walsh, Thomas G. Koch and Michael S. Kallos

    Citation: Journal of Biological Engineering 2019 13:25

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  10. Content type: Research

    Gamma (γ)-Aminobutyric acid (GABA) as a bioactive compound is used extensively in functional foods, pharmaceuticals and agro-industry. It can be biosynthesized via decarboxylation of monosodium glutamate (MSG)...

    Authors: Haina Yuan, Hongbo Wang, Ozkan Fidan, Yong Qin, Gongnian Xiao and Jixun Zhan

    Citation: Journal of Biological Engineering 2019 13:24

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  11. Content type: Research

    Partially acetylated chito-oligosaccharides (paCOS) have a variety of potential applications in different fields, but to harness their benefits, pure paCOS or well-defined paCOS mixtures are essential. For exa...

    Authors: David Gercke, Eva K. Regel, Ratna Singh and Bruno M. Moerschbacher

    Citation: Journal of Biological Engineering 2019 13:23

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  12. Content type: Research

    Various hepatic models mimicking liver lobules have been investigated to evaluate the potential hepatotoxic effects of chemicals and drugs, but in vitro hepatic models of zonal hepatotoxicity have not yet been...

    Authors: Jaehwan Ahn, Jun-Ho Ahn, Seokjoo Yoon, Yoon Sung Nam, Mi-Young Son and Jung-Hwa Oh

    Citation: Journal of Biological Engineering 2019 13:22

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  13. Content type: Research

    Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1), a long non coding RNA (lncRNA) present in serum, is an important biomarker for detecting hepatocellular carcinoma (HCC). However, there are some...

    Authors: Fei Liu, Tao Li, Liqun Zhang, Guiming Xiang, Dongneng Jiang, Dianji Tu, Linlin Liu, Yi Li, Chang Liu and Xiaoyun Pu

    Citation: Journal of Biological Engineering 2019 13:21

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  14. Content type: Research

    Frame-shifted genes results in non-functional peptides. Because of this complete loss of function, frame-shifted genes have never been used in constructing synthetic gene circuits.

    Authors: Kathakali Sarkar, Sayak Mukhopadhyay, Deepro Bonnerjee, Rajkamal Srivastava and Sangram Bagh

    Citation: Journal of Biological Engineering 2019 13:20

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  15. Content type: Review

    Broad translational success of RNA interference (RNAi) technology depends on the development of effective delivery approaches. To that end, researchers have developed a variety of strategies, including chemica...

    Authors: Alex Eli Pottash, Christopher Kuffner, Madeleine Noonan-Shueh and Steven M. Jay

    Citation: Journal of Biological Engineering 2019 13:19

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  16. Content type: Research

    Fed-batch conditions are advantageous for industrial cultivations as they avoid unfavorable phenomena appearing in batch cultivations. Those are for example the formation of overflow metabolites, catabolite re...

    Authors: T. Keil, B. Dittrich, C. Lattermann, T. Habicher and J. Büchs

    Citation: Journal of Biological Engineering 2019 13:18

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  17. Content type: Research

    Cardiac fibrosis is the most common pathway of many cardiac diseases. To date, there has been no suitable in vitro cardiac fibrosis model that could sufficiently mimic the complex environment of the human hear...

    Authors: Mi-Ok Lee, Kwang Bo Jung, Seong-Jae Jo, Sung-Ae Hyun, Kyoung-Sik Moon, Joung-Wook Seo, Sang-Heon Kim and Mi-Young Son

    Citation: Journal of Biological Engineering 2019 13:15

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  18. Content type: Letters to the Editor

    Detecting the arbitrary movements of fast-moving insects under field conditions is notoriously difficult because existing technologies are limited by issues of size, weight, range and cost. Here, we establish ...

    Authors: Sarah E. Barlow, Mark A. O’Neill and Bruce M. Pavlik

    Citation: Journal of Biological Engineering 2019 13:13

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  19. Content type: Review

    Digitalization of health care practices is substantially manifesting itself as an effective tool to diagnose and rectify complex cardiovascular abnormalities. For cardiovascular abnormalities, precise non-inva...

    Authors: Rajat Vashistha, Prasoon Kumar, Arun Kumar Dangi, Naveen Sharma, Deepak Chhabra and Pratyoosh Shukla

    Citation: Journal of Biological Engineering 2019 13:12

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  20. Content type: Research

    Erythromycin A (Er-A) produced by the actinomycete Saccharopolyspora erythraea is an important antibiotic extensively used in human medicine. Dissecting of transcriptional regulators and their target genes associ...

    Authors: Hang Wu, Zuling Chu, Wanxiang Zhang, Chi Zhang, Jingshu Ni, Heshi Fang, Yuhong Chen, Yansheng Wang, Lixin Zhang and Buchang Zhang

    Citation: Journal of Biological Engineering 2019 13:11

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  21. Content type: Research

    ADAMTS13 (A disintegrin and metalloprotease with a thrombospondin type 1 motif 13) cleaves Von Willebrand factor (VWF) to regulate its size, thereby preventing aberrant platelet aggregation and thrombus. Defic...

    Authors: Shanshan Yu, Wang Liu, Jinhua Fang, Xiaozhong Shi, Jianhua Wu, Ying Fang and Jiangguo Lin

    Citation: Journal of Biological Engineering 2019 13:9

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  22. Content type: Methodology

    The automation of modular cloning methodologies permits the assembly of many genetic designs. Utilising characterised biological parts aids in the design and redesign of genetic pathways. The characterisation ...

    Authors: Kealan Exley, Christopher Robert Reynolds, Lorna Suckling, Soo Mei Chee, Argyro Tsipa, Paul S. Freemont, David McClymont and Richard Ian Kitney

    Citation: Journal of Biological Engineering 2019 13:8

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  23. Content type: Research

    Cardiovascular disease and myocardial infarction are associated with high mortality and morbidity and a more effective treatment remains a major clinical need. The intramyocardial injection of biomaterials has...

    Authors: David J. Lee, Maria A. Cavasin, Adam J. Rocker, Danielle E. Soranno, Xianzhong Meng, Robin Shandas and Daewon Park

    Citation: Journal of Biological Engineering 2019 13:6

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  24. Content type: Review

    The research community is intent on harnessing increasingly complex biological building blocks. At present, cells represent a highly functional component for integration into higher order systems. In this revi...

    Authors: Kara A. Davis, Pei-Jung Wu, Calvin F. Cahall, Cong Li, Anuhya Gottipati and Brad J. Berron

    Citation: Journal of Biological Engineering 2019 13:5

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  25. Content type: Review

    The onset of cancer metastasis is the defining event in cancer progression when the disease is considered lethal. The ability of metastatic cancer cells to stay dormant for extended time periods and reawaken a...

    Authors: Shreyas S. Rao, Raghu Vamsi Kondapaneni and Akshay A. Narkhede

    Citation: Journal of Biological Engineering 2019 13:3

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  26. Content type: Review

    Metastatic recurrence is a major hurdle to overcome for successful control of cancer-associated death. Residual tumor cells in the primary site, or disseminated tumor cells in secondary sites, can lie in a dor...

    Authors: Shantanu Pradhan, John L. Sperduto, Cindy J. Farino and John H. Slater

    Citation: Journal of Biological Engineering 2018 12:37

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  27. Content type: Review

    Angiogenesis is touted as a fundamental procedure in the regeneration and restoration of different tissues. The induction of de novo blood vessels seems to be vital to yield a successful cell transplantation r...

    Authors: Shirin Saberianpour, Morteza Heidarzadeh, Mohammad Hossein Geranmayeh, Hossein Hosseinkhani, Reza Rahbarghazi and Mohammad Nouri

    Citation: Journal of Biological Engineering 2018 12:36

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  28. Content type: Research

    Cell-based therapy by transplantation of nucleus pulposus (NP) progenitor/notochordal cells has been proposed as a promising way to halt and reverse the progression of disc degeneration. Although some studies ...

    Authors: Zhuochao Liu, Zhiyong Zheng, Jin Qi, Jun Wang, Qi Zhou, Fangqiong Hu, Jing Liang, Changwei Li, Weibin Zhang and Xingkai Zhang

    Citation: Journal of Biological Engineering 2018 12:35

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  29. Content type: Research

    Pectin is a rather complex and highly branched polysaccharide strengthening the plant cell wall. Thus, many different pectinases are required for an efficient microbial conversion of biomass waste streams with...

    Authors: Markus Jan Müller, Sarah Stachurski, Peter Stoffels, Kerstin Schipper, Michael Feldbrügge and Jochen Büchs

    Citation: Journal of Biological Engineering 2018 12:34

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  30. Content type: Review

    CRISPR/Cas9 (Clustered Regularly Interspaced Short Palindromic Repeats) is today one of the most reliable method for gene-editing, supporting previous gene therapies technologies such as TALEN, Meganucleases a...

    Authors: Alessio Biagioni, Anna Laurenzana, Francesca Margheri, Anastasia Chillà, Gabriella Fibbi and Mario so

    Citation: Journal of Biological Engineering 2018 12:33

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  31. Content type: Review

    The lymphatic system is a major circulatory system within the body, responsible for the transport of interstitial fluid, waste products, immune cells, and proteins. Compared to other physiological systems, the...

    Authors: Laura Alderfer, Alicia Wei and Donny Hanjaya-Putra

    Citation: Journal of Biological Engineering 2018 12:32

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  32. Content type: Research

    Biological systems have complicated environmental conditions that vary both spatially and temporally. It becomes necessary to impose time-varying soluble factor concentrations to study such systems, including ...

    Authors: Joshua Garrison, Zidong Li, Barath Palanisamy, Ling Wang and Erkin Seker

    Citation: Journal of Biological Engineering 2018 12:31

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  33. Content type: Research

    Silkworm genetic engineering is widely used in gene function, silk engineering and disease-resistant engineering in most of Asia. Some of the earliest promoter elements are used to control the development of s...

    Authors: Zhan-Qi Dong, Zhi-Gang Hu, Hai-Qing Li, Ya-Ming Jiang, Ming-Ya Cao, Peng Chen, Cheng Lu and Min-Hui Pan

    Citation: Journal of Biological Engineering 2018 12:30

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  34. Content type: Review

    The retinal pigment epithelium (RPE) is essential to the health of the retina and the proper functioning of the photoreceptors. The RPE is rich in melanosomes, which contain the pigment melanin. Changes in RPE...

    Authors: Maryse Lapierre-Landry, Joseph Carroll and Melissa C. Skala

    Citation: Journal of Biological Engineering 2018 12:29

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  35. Content type: Review

    Cell-based therapy has expanded its influence in cancer immunotherapy, regenerative medicine, and tissue engineering. Due to their secretory functions, differentiation capabilities, specific homing effects thr...

    Authors: Daniel Y. Lee, Byung-Hyun Cha, Minjin Jung, Angela S. Kim, David A. Bull and Young-Wook Won

    Citation: Journal of Biological Engineering 2018 12:28

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  36. Content type: Research

    Standard microorganism isolating technology applied for complex multiphase environmental samples such as soil or sediment needs pre-treatment steps to remove living cells from their mixed-phase microniche, by ...

    Authors: M. V. Gorlenko, E. A. Chutko, E. S. Churbanova, N. V. Minaev, K. I. Kachesov, L. V. Lysak, S. A. Evlashin, V. S. Cheptsov, A. O. Rybaltovskiy, V. I. Yusupov, V. S. Zhigarkov, G. A. Davydova, B. N. Chichkov and V. N. Bagratashvili

    Citation: Journal of Biological Engineering 2018 12:27

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  37. Content type: Research

    In vitro expansion of mesenchymal stem cells (MSCs) has been implicated in loss of multipotency, leading to impaired chondrogenic potential and an eventual therapeutic effect, as reported in our previous study...

    Authors: Chong Shen, Tongmeng Jiang, Bo Zhu, Yiguan Le, Jianwei Liu, Zainen Qin, Haimin Chen, Gang Zhong, Li Zheng, Jinmin Zhao and Xingdong Zhang

    Citation: Journal of Biological Engineering 2018 12:26

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  38. Content type: Research

    Oleaginous fungi are efficient tools to convert agricultural waste streams into valuable components. The filamentous fungus Mucor circinelloides was cultivated in whey permeate, a byproduct from cheese production...

    Authors: Lauryn G. Chan, Joshua L. Cohen, Gulustan Ozturk, Marie Hennebelle, Ameer Y. Taha and Juliana Maria L. N. de Moura Bell

    Citation: Journal of Biological Engineering 2018 12:25

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  39. Content type: Research

    The seeding of scaffolds with the stromal vascular fraction (SVF) of adipose tissue is a common prevascularization strategy in tissue engineering. Alternatively, adipose tissue-derived microvascular fragments ...

    Authors: Thomas Später, Florian S. Frueh, Ruth M. Nickels, Michael D. Menger and Matthias W. Laschke

    Citation: Journal of Biological Engineering 2018 12:24

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  40. Content type: Letters to the Editor

    A primary objective of synthetic biology is the construction of genetic circuits with behaviors that can be predicted based on the properties of the constituent genetic parts from which they are built. However...

    Authors: Kalen P. Clifton, Ethan M. Jones, Sudip Paudel, John P. Marken, Callan E. Monette, Andrew D. Halleran, Lidia Epp and Margaret S. Saha

    Citation: Journal of Biological Engineering 2018 12:23

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  41. Content type: Research

    Fermentation condition optimization and nutrients screening are of equal importance for efficient production of plasmid DNA vaccines. This directly affects the downstream purification and final quality and yie...

    Authors: Juan Long, Xiao Zhao, Fei Liang, Nan Liu, Yuying Sun and Yongzhi Xi

    Citation: Journal of Biological Engineering 2018 12:22

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