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  1. Inulinase can hydrolyze polyfructan into high-fructose syrups and fructoligosaccharides, which are widely used in food, the medical industry and the biorefinery of Jerusalem artichoke. In the present study, a rec...

    Authors: Junyan Ma, Qian Li, Haidong Tan, Hao Jiang, Kuikui Li, Lihua Zhang, Quan Shi and Heng Yin

    Citation: Journal of Biological Engineering 2019 13:81

    Content type: Research

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  2. The main issue in cutaneous regeneration is to develop engineered scaffolds based on natural extracellular matrix to promote dynamics of skin progenitor cells and accelerate differentiation into mature keratin...

    Authors: Leila Mohammadzadeh, Reza Rahbarghazi, Roya Salehi and Mehrdad Mahkam

    Citation: Journal of Biological Engineering 2019 13:79

    Content type: Research

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  3. Influenza viruses cause hundreds of thousands of respiratory diseases worldwide each year, and vaccination is considered the most effective approach for preventing influenza annual epidemics or pandemics. Sinc...

    Authors: Chia-Chun Lai, Yu-Chieh Cheng, Pin-Wen Chen, Ting-Hui Lin, Tsai-Teng Tzeng, Chia-Chun Lu, Min-Shi Lee and Alan Yung-Chih Hu

    Citation: Journal of Biological Engineering 2019 13:78

    Content type: Research

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  4. The baculovirus (BV) Autographa californica multiple nuclear polyhedrosis virus has been used in numerous protein expression systems because of its ability to infect insect cells and serves as a useful vaccinatio...

    Authors: Keigo Kondou, Tomoyuki Suzuki, Myint Oo Chang and Hiroshi Takaku

    Citation: Journal of Biological Engineering 2019 13:77

    Content type: Research

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  5. The promise of biopharmaceuticals comprising one or more binding domains motivates the development of novel methods for de novo isolation and affinity maturation of virion-binding domains. Identifying avenues ...

    Authors: Pete Heinzelman, Alyssa Low, Rudo Simeon, Gus A. Wright and Zhilei Chen

    Citation: Journal of Biological Engineering 2019 13:76

    Content type: Research

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  6. Gene regulatory networks with different topological and/or dynamical properties might exhibit similar behavior. System that is less perceptive for the perturbations of its internal and external factors should ...

    Authors: Žiga Pušnik, Miha Mraz, Nikolaj Zimic and Miha Moškon

    Citation: Journal of Biological Engineering 2019 13:75

    Content type: Methodology

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    The Correction to this article has been published in Journal of Biological Engineering 2019 13:84

  7. Since their inception, human induced pluripotent stem cells (hiPSCs) have held much promise for pharmacological applications and cell-based therapies. However, their potential can only be realised if large num...

    Authors: Diogo E. S. Nogueira, Carlos A. V. Rodrigues, Marta S. Carvalho, Cláudia C. Miranda, Yas Hashimura, Sunghoon Jung, Brian Lee and Joaquim M. S. Cabral

    Citation: Journal of Biological Engineering 2019 13:74

    Content type: Research

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  8. Jamming state transition has been used in literature to describe migrating-to-resting cell state transition during collective cell migration without proper rheological confirmation. Yield stress often has been...

    Authors: Ivana Pajic-Lijakovic and Milan Milivojevic

    Citation: Journal of Biological Engineering 2019 13:73

    Content type: Research

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  9. The green algae balls (Aegagropila linnaei), known as Marimo, are large spherical colonies of live photosynthetic filaments, formed by rolling water currents in freshwater lakes. Photosynthesis therein produces g...

    Authors: Neil Phillips, Thomas C. Draper, Richard Mayne and Andrew Adamatzky

    Citation: Journal of Biological Engineering 2019 13:72

    Content type: Research

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  10. MicroRNAs (miRNAs) are implicated in the progression of ischemic stroke (IS) and bone marrow-derived mesenchymal stem cells (BMSCs)-derived exosomes play a role in IS therapy. Herein we hypothesized that the B...

    Authors: Yiming Deng, Duanduan Chen, Feng Gao, Hong Lv, Guojun Zhang, Xuan Sun, Lian Liu, Dapeng Mo, Ning Ma, Ligang Song, Xiaochuan Huo, Tianyi Yan, Jingbo Zhang and Zhongrong Miao

    Citation: Journal of Biological Engineering 2019 13:71

    Content type: Research

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  11. Whole cell biosensors provide a simple method for the detection of heavy metals. However, previous designs of them rely primarily on simulation of heavy metal resistance systems of bacteria.

    Authors: Mingzhang Guo, Ruoxi Du, Zixin Xie, Xiaoyun He, Kunlun Huang, Yunbo Luo and Wentao Xu

    Citation: Journal of Biological Engineering 2019 13:70

    Content type: Research

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  12. Non-alcoholic fatty liver disease (NAFLD) begins as simple hepatic steatosis, but further progress to chronic liver diseases results in severe liver damage and hepatic failure. However, therapeutic options are...

    Authors: Jae-Sung Ryu, Minji Lee, Seon Ju Mun, Sin-Hyoung Hong, Ho-Joon Lee, Hyo-Suk Ahn, Kyung-Sook Chung, Gun-Hwa Kim and Myung Jin Son

    Citation: Journal of Biological Engineering 2019 13:69

    Content type: Research

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  13. Mesenchymal stem cells (MSCs) show tremendous promise as a cell source for tissue engineering and regenerative medicine, and are understood to be mechanosensitive to external mechanical environments. In recent...

    Authors: Tasneem Bouzid, Eunju Kim, Brandon D. Riehl, Amir Monemian Esfahani, Jordan Rosenbohm, Ruiguo Yang, Bin Duan and Jung Yul Lim

    Citation: Journal of Biological Engineering 2019 13:68

    Content type: Review

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  14. Neuromodulation of central and peripheral neural circuitry brings together neurobiologists and neural engineers to develop advanced neural interfaces to decode and recapitulate the information encoded in the n...

    Authors: Benjamin J. Seicol, Sebastian Bejarano, Nicholas Behnke and Liang Guo

    Citation: Journal of Biological Engineering 2019 13:67

    Content type: Review

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  15. Endophytic microorganisms are a rich source of bioactive natural products. They are considered as promising biofertilizers and biocontrol agents due to their growth-promoting interactions with the host plants ...

    Authors: Ozkan Fidan and Jixun Zhan

    Citation: Journal of Biological Engineering 2019 13:66

    Content type: Research

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  16. Creating designer molecules using a combination of select domains from polyketide synthases and/or nonribosomal peptide synthetases (NRPS) continues to be a synthetic goal. However, an incomplete understanding...

    Authors: Fuchao Xu, Russell Butler, Kyle May, Megi Rexhepaj, Dayu Yu, Jiachen Zi, Yi Chen, Yonghong Liang, Jia Zeng, Joan Hevel and Jixun Zhan

    Citation: Journal of Biological Engineering 2019 13:65

    Content type: Research

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  17. Significant rise in concentration of saline wastewater entering the treatment plants has been resulting in many problems in the biological treatment processes. On the other hand, the specific conditions of phy...

    Authors: Mostafa Tizghadam Ghazani and Alireza Taghdisian

    Citation: Journal of Biological Engineering 2019 13:64

    Content type: Research

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  18. Silk glands are used by silkworms to spin silk fibers for making their cocoons. These have recently been regarded as bioreactor hosts for the cost-effective production of other valuable exogenous proteins and ...

    Authors: Sheng Xu, Feng Wang, Yuancheng Wang, Riyuan Wang, Kai Hou, Chi Tian, Yanting Ji, Qianqian Yang, Ping Zhao and Qingyou Xia

    Citation: Journal of Biological Engineering 2019 13:61

    Content type: Research

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  19. As a type of chronic autoimmune joint disease, rheumatoid arthritis (RA) is a disorder, characterized by a variety of physical symptoms as well as RA fibroblast-like synoviocyte (RA-FLS) proliferation. More re...

    Authors: Chun-Wang Zhang, Xia Wu, Dan Liu, Wei Zhou, Wei Tan, Yu-Xuan Fang, Yu Zhang, Yan-Qing Liu and Guo-Qing Li

    Citation: Journal of Biological Engineering 2019 13:60

    Content type: Research

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  20. The production of recombinant proteins in mammalian cell lines is one of the most important areas in biopharmaceutical industry. Viral transcriptional promoters are widely used to express recombinant proteins ...

    Authors: Roberto A Zúñiga, Matías Gutiérrez-González, Norberto Collazo, Pablo Hérnan Sotelo, Carolina H Ribeiro, Claudia Altamirano, Carmen Lorenzo, Juan Carlos Aguillón and María Carmen Molina

    Citation: Journal of Biological Engineering 2019 13:59

    Content type: Research

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  21. Traditional cancer therapies, such as surgery treatment, radiotherapy, and chemotherapy, often fail to completely eliminate tumor cells in an anaerobic microenvironment of tumor regions.

    Authors: Lian He, Huijun Yang, Jianli Tang, Zhudong Liu, Yiyan Chen, Binghua Lu, Haocheng He, Sijia Tang, Yunjun Sun, Fei Liu, Xuezhi Ding, Youming Zhang, Shengbiao Hu and Liqiu Xia

    Citation: Journal of Biological Engineering 2019 13:58

    Content type: Research

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  22. The purpose of this review is to assess the state-of-the-art fabrication methods, advances in genome editing, and the use of machine learning to shape the prospective growth in cardiac tissue engineering. Thos...

    Authors: Anh H. Nguyen, Paul Marsh, Lauren Schmiess-Heine, Peter J. Burke, Abraham Lee, Juhyun Lee and Hung Cao

    Citation: Journal of Biological Engineering 2019 13:57

    Content type: Review

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  23. Immunotoxins consisting of a toxin from bacteria or plants and a targeting module have been developed as potent anti-cancer therapeutics. The majority of them, especially those in preclinical or clinical testi...

    Authors: Byeong Sung Lee, Yumi Lee, Jisoo Park, Bo Seok Jeong, Migyeong Jo, Sang Taek Jung and Tae Hyeon Yoo

    Citation: Journal of Biological Engineering 2019 13:56

    Content type: Research

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  24. Engineered living materials (ELMs) are an exciting new frontier, where living organisms create highly functional materials. In particular, protein ELMs have the advantage that their properties can be manipulat...

    Authors: Daniel T. Peters, Helen Waller, Mark A. Birch and Jeremy H. Lakey

    Citation: Journal of Biological Engineering 2019 13:54

    Content type: Research

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  25. A transcriptional reporter is the key component in bacterial biosensors which are employed to monitor the induction or repression of a reporter gene corresponding to environmental change. Interaction of a tran...

    Authors: Xingjuan Chen, Xin Jiang, Cuijuan Tie, Jinnon Yoo, Yan Wang, Meiying Xu, Guoping Sun, Jun Guo and Xianqiang Li

    Citation: Journal of Biological Engineering 2019 13:53

    Content type: Research

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  26. Biofilters are soil-plant based passive stormwater treatment systems which demonstrate promising, although inconsistent, removal of faecal microorganisms. Antimicrobial-producing plants represent a safe, inexp...

    Authors: P. Galbraith, R. Henry and D. T. McCarthy

    Citation: Journal of Biological Engineering 2019 13:52

    Content type: Research

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  27. We herein describe a personal glucose meter (PGM)-based method for a label-free and washing-free determination of alkaline phosphatase (ALP) activity, which relies on the cascade enzymatic reactions promoted b...

    Authors: Jun Ki Ahn, Hyo Yong Kim, Chang Yeol Lee, Ki Soo Park and Hyun Gyu Park

    Citation: Journal of Biological Engineering 2019 13:51

    Content type: Letter to the Editor

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  28. Osteoporosis (OP) is a condition featured by bone mass loss and bone tissue microarchitectural alterations due to impaired tissue homeostasis favoring excessive bone resorption versus deposition. The trigger o...

    Authors: Shaojin Liu, Hongxing Huang, Shuang Chai, Hewei Wei, Jiachun Huang and Lei Wan

    Citation: Journal of Biological Engineering 2019 13:50

    Content type: Research

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  29. Myocardial infarction (MI) is a common cause of mortality in people. Mesenchymal stem cell (MSC) has been shown to exert therapeutic potential to treat myocardial infarction (MI). However, in patients with dia...

    Authors: Xin Meng, Minjuan Zheng, Ming Yu, Wei Bai, Lei Zuo, Xin Bu, Yi Liu, Linying Xia, Jing Hu, Liwen Liu and Jianping Li

    Citation: Journal of Biological Engineering 2019 13:49

    Content type: Research

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  30. Traditional therapeutics and vaccines represent the bedrock of modern medicine, where isolated biochemical molecules or designed proteins have led to success in treating and preventing diseases. However, sever...

    Authors: Max Levy, Partha P. Chowdhury and Prashant Nagpal

    Citation: Journal of Biological Engineering 2019 13:48

    Content type: Review

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  31. Hospital wastewater is commonly polluted with high loads of pharmaceutically active compounds, which pass through wastewater treatment plants (WWTPs) and end up in water bodies, posing ecological and health ri...

    Authors: Josep Anton Mir-Tutusaus, Eloi Parladé, Marta Villagrasa, Damià Barceló, Sara Rodríguez-Mozaz, Maira Martínez-Alonso, Núria Gaju, Montserrat Sarrà and Glòria Caminal

    Citation: Journal of Biological Engineering 2019 13:47

    Content type: Research

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  32. Tumor numerical models have been used to quantify solute transport with a single capillary embedded in an infinite tumor expanse, but measurements from different mammalian tumors suggest that a tissue containi...

    Authors: Sreyashi Chakraborty, Alican Ozkan, Marissa Nichole Rylander, Wendy A. Woodward and Pavlos Vlachos

    Citation: Journal of Biological Engineering 2019 13:46

    Content type: Research

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  33. More than five million Americans suffer from heart valve disease annually, a condition that worsens cardiac function and gradually leads to heart failure if appropriate treatment is not performed on time. Curr...

    Authors: Ngoc Thien Lam, Ishita Tandon and Kartik Balachandran

    Citation: Journal of Biological Engineering 2019 13:45

    Content type: Research

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  34. Coumarins play roles in many biological processes. Angelica decursiva is one of the major sources of coumarins in China. Due to increasing demand for coumarins in the marketplace, traditional extraction from plan...

    Authors: Yucheng Zhao, Xiangyun Jian, Jialin Wu, Wanchun Huang, Chuanlong Huang, Jun Luo and Lingyi Kong

    Citation: Journal of Biological Engineering 2019 13:44

    Content type: Research

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  35. Metabolic labeling of proteins with non-canonical amino acids (ncAAs) provides unique bioorthogonal chemical groups during de novo synthesis by taking advantage of both endogenous and heterologous protein synt...

    Authors: Aya M. Saleh, Kristen M. Wilding, Sarah Calve, Bradley C. Bundy and Tamara L. Kinzer-Ursem

    Citation: Journal of Biological Engineering 2019 13:43

    Content type: Review

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  36. Cephalometric analysis is used to evaluate facial growth, to study the anatomical relationships within the face. Cephalometric assessment is based on 2D radiographic images, either the sagittal or coronal plan...

    Authors: Manuel Pinheiro, Xinhui Ma, Michael J. Fagan, Grant T. McIntyre, Ping Lin, Gautham Sivamurthy and Peter A. Mossey

    Citation: Journal of Biological Engineering 2019 13:42

    Content type: Methodology

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  37. Olfactory ensheathing cell (OEC) transplantation is emerging as a promising therapy for spinal cord injuries. However, outcomes are inconsistent, and the method needs improvement. Currently, cells are injected...

    Authors: Lachlan J. Beckingham, Michael Todorovic, Johana Tello Velasquez, Marie-Laure Vial, Mo Chen, Jenny A. K. Ekberg and James A. St John

    Citation: Journal of Biological Engineering 2019 13:41

    Content type: Research

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  38. The application of synthetic modified messenger RNA (mRNA) is a promising approach for the treatment of a variety of diseases and vaccination. In the past few years, different modifications of synthetic mRNA w...

    Authors: Tatjana Michel, Sonia Golombek, Heidrun Steinle, Ludmilla Hann, Ana Velic, Boris Macek, Stefanie Krajewski, Christian Schlensak, Hans Peter Wendel and Meltem Avci-Adali

    Citation: Journal of Biological Engineering 2019 13:40

    Content type: Research

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  39. The availability of renewable energy technologies is increasing dramatically across the globe thanks to their growing maturity. However, large scale electrical energy storage and retrieval will almost certainl...

    Authors: Farshid Salimijazi, Erika Parra and Buz Barstow

    Citation: Journal of Biological Engineering 2019 13:38

    Content type: Review

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  40. In the original version of this article [1], published on 18 December 2018, there was 1 incorrect author name.

    Authors: Alessio Biagioni, Anna Laurenzana, Francesca Margheri, Anastasia Chillà, Gabriella Fibbi and Mario Del Rosso

    Citation: Journal of Biological Engineering 2019 13:37

    Content type: Publisher Correction

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    The original article was published in Journal of Biological Engineering 2018 12:33

  41. The luminal surface of the small intestine is composed of a monolayer of cells overlying a lamina propria comprised of extracellular matrix (ECM) proteins. The ECM provides a porous substrate critical for nutrien...

    Authors: Jennifer E. Speer, Dulan B. Gunasekara, Yuli Wang, John K. Fallon, Peter J. Attayek, Philip C. Smith, Christopher E. Sims and Nancy L. Allbritton

    Citation: Journal of Biological Engineering 2019 13:36

    Content type: Research

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  42. CRISPR/Cas9 system is a powerful tool for knocking out genes in cells. However, genes essential for cell survival cannot be directly knocked out. Traditionally, generation of conditional knockout cells require...

    Authors: Bei Wang, Zishi Wang, Daqi Wang, Baolong Zhang, Sang-Ging Ong, Mingqing Li, Wenqiang Yu and Yongming Wang

    Citation: Journal of Biological Engineering 2019 13:35

    Content type: Research

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  43. The adoptive transfer of human T cells or genetically-engineered T cells with cancer-targeting receptors has shown tremendous promise for eradicating tumors in clinical trials. The objective of this study was ...

    Authors: Jianfa Ou, Yingnan Si, Yawen Tang, Grace E. Salzer, Yun Lu, Seulhee Kim, Hongwei Qin, Lufang Zhou and Xiaoguang Liu

    Citation: Journal of Biological Engineering 2019 13:34

    Content type: Research

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  44. Glycine cleavage system (GCS) plays a key role in one-carbon (C1) metabolism related to the biosynthesis of a number of key intermediates with significance in both biomedicine and biotechnology. Despite extens...

    Authors: Xinyi Zhang, Mei Li, Yingying Xu, Jie Ren and An-Ping Zeng

    Citation: Journal of Biological Engineering 2019 13:32

    Content type: Research

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