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  1. The skin serves as a barrier to protect the body from environmental microorganisms and is the largest tissue of the body and any damage must be quickly and effectively repaired. The fundamental purpose of derm...

    Authors: Maryam Ghahremani-Nasab, Azizeh Rahmani Del Bakhshayesh, Naeimeh Akbari-Gharalari and Ahmad Mehdipour
    Citation: Journal of Biological Engineering 2023 17:62
  2. Multicomponent nanoparticle systems are known for their varied properties and functions, and have shown potential as gene nanocarriers. This study aims to synthesize and characterize ternary nickel–cobalt-ferr...

    Authors: Hajar Q. Alijani, Mehrdad Khatami, Masoud Torkzadeh-Mahani, Jan Michalička, Wu Wang, Di Wang and Abolfazl Heydari
    Citation: Journal of Biological Engineering 2023 17:61
  3. Calcific aortic valve disease (CAVD) causes an increasing health burden in the 21st century due to aging population. The complex pathophysiology remains to be understood to develop novel prevention and treatment ...

    Authors: Claudia Dittfeld, Maximilian Winkelkotte, Anna Scheer, Emmely Voigt, Florian Schmieder, Stephan Behrens, Anett Jannasch, Klaus Matschke, Frank Sonntag and Sems-Malte Tugtekin
    Citation: Journal of Biological Engineering 2023 17:60
  4. Mastitis poses a major threat to dairy farms globally; it results in reduced milk production, increased treatment costs, untimely compromised genetic potential, animal deaths, and economic losses. Streptococcus a...

    Authors: Rajesh Kumar Pathak and Jun-Mo Kim
    Citation: Journal of Biological Engineering 2023 17:59
  5. A number of molecular biofactors have been documented in pathogenesis and poor prognosis of colorectal cancer (CRC). Among them, the Hypoxia-Inducible Factor (HIF-1a) is frequently reported to become over-expr...

    Authors: Azar Bakand, Sevil Vaghefi Moghaddam, Maryam Naseroleslami, Helder André, Neda Mousavi-Niri and Effat Alizadeh
    Citation: Journal of Biological Engineering 2023 17:58
  6. Fungi have evolved unique metabolic regulation mechanisms for adapting to the changing environments. One of the key features of fungal adaptation is the production of secondary metabolites (SMs), which are ess...

    Authors: Wenbin Yu, Rongqiang Pei, Yufei Zhang, Yayi Tu and Bin He
    Citation: Journal of Biological Engineering 2023 17:57
  7. The use of biodegradable polymers for treating bone-related diseases has become a focal point in the field of biomedicine. Recent advancements in material technology have expanded the range of materials suitab...

    Authors: Wenqing Liang, Chao Zhou, Hongwei Zhang, Juqin Bai, Bo Jiang, Chanyi Jiang, Wenyi Ming, Hengjian Zhang, Hengguo Long, Xiaogang Huang and Jiayi Zhao
    Citation: Journal of Biological Engineering 2023 17:56
  8. Tissue-integrated micro-electronic devices for neural stimulation hold great potential in restoring the functionality of degenerated organs, specifically, retinal prostheses, which are aimed at vision restorat...

    Authors: Gal Shpun, Nairouz Farah, Yoav Chemla, Amos Markus, Tamar Azrad Leibovitch, Erel Lasnoy, Doron Gerber, Zeev Zalevsky and Yossi Mandel
    Citation: Journal of Biological Engineering 2023 17:55
  9. The approval of anticancer therapeutic strategies is still slowed down by the lack of models able to faithfully reproduce in vivo cancer physiology. On one hand, the conventional in vitro models fail to recapi...

    Authors: Elisa Cauli, Michela Anna Polidoro, Simona Marzorati, Claudio Bernardi, Marco Rasponi and Ana Lleo
    Citation: Journal of Biological Engineering 2023 17:53
  10. Radiofrequency Cardiac Ablation (RFCA) is a common procedure that heats cardiac tissue to destroy abnormal signal pathways to eliminate arrhythmias. The complex multiphysics phenomena during this procedure nee...

    Authors: Patcharaporn Wongchadakul, Ashim K. Datta and Phadungsak Rattanadecho
    Citation: Journal of Biological Engineering 2023 17:52
  11. Microfluidic devices have emerged as powerful tools for cell-based experiments, offering a controlled microenvironment that mimic the conditions within the body. Numerous cell experiment studies have successfu...

    Authors: Seungjin Lee, Jinseop Ahn, Seok-Man Kim, Daehan Kim, Jiun Yeom, Jeongmok Kim, Joong Yull Park and Buom-Yong Ryu
    Citation: Journal of Biological Engineering 2023 17:51
  12. Ischemic stroke accounts for 70–80% of all stroke cases, leading to over two million people dying every year. Poor diagnosis and late detection are the major causes of the high death and disability rate.

    Authors: Jiefeng Luo, Dingzhi Chen, Yujia Mei, Hepeng Li, Biyun Qin, Xiao Lin, Ting Fung Chan, Keng Po Lai and Deyan Kong
    Citation: Journal of Biological Engineering 2023 17:50
  13. In recent decades, human mesenchymal stem cells (hMSCs) have gained momentum in the field of cell therapy for treating cartilage and bone injuries. Despite the tri-lineage multipotency, proliferative propertie...

    Authors: Natalia Carballo-Pedrares, Federica Ponti, Junquera Lopez-Seijas, Diego Miranda-Balbuena, Nina Bono, Gabriele Candiani and Ana Rey-Rico
    Citation: Journal of Biological Engineering 2023 17:49
  14. Spinal cord injury (SCI) is a serious injury with high mortality and disability rates, and there is no effective treatment at present. It has been reported that some treatments, such as drug intervention and s...

    Authors: Tiemei Liu, Qiang Zhang, Hongru Li, Xiaoqian Cui, Zhiping Qi and Xiaoyu Yang
    Citation: Journal of Biological Engineering 2023 17:48
  15. The currently employed tooth extraction methods in dentistry involve mechanical disruption of the periodontal ligament fibers, leading to inevitable trauma to the bundle bone comprising the socket walls. In ou...

    Authors: Tamar Ansbacher, Ran Tohar, Adi Cohen, Orel Cohen, Shifra Levartovsky, Adi Arieli, Shlomo Matalon, Daniel Z. Bar, Maayan Gal and Evgeny Weinberg
    Citation: Journal of Biological Engineering 2023 17:47
  16. Hormone-dependent promoters are very efficient in transgene expression. Plasmid-based reporter assays have identified regulatory sequences of the Ovalbumin promoter that are involved in response to estrogen and h...

    Authors: Sara Yousefi Taemeh, Nima Dehdilani, Lena Goshayeshi, Sylvie Rival-Gervier, Jalil Mehrzad, Bertrand Pain and Hesam Dehghani
    Citation: Journal of Biological Engineering 2023 17:46
  17. Novel bone substitutes are urgently needed in experimental research and clinical orthopaedic applications. There are many traditional Chinese medicines that have effects on bone repair. However, application of...

    Authors: Feng Wu, Zhenxu Wu, Zhijun Ye, Guoqing Niu, Zhiliang Ma and Peibiao Zhang
    Citation: Journal of Biological Engineering 2023 17:45
  18. Mesenchymal stem/stromal cells (MSCs) have been carefully examined to have tremendous potential in regenerative medicine. With their immunomodulatory and regenerative properties, MSCs have numerous application...

    Authors: Vitali V. Maldonado, Neel H. Patel, Emma E. Smith, C. Lowry Barnes, Michael P. Gustafson, Raj R. Rao and Rebekah M. Samsonraj
    Citation: Journal of Biological Engineering 2023 17:44
  19. Modular tissue engineering (MTE) is a novel “bottom-up” approach that aims to mimic complex tissue microstructural features. The constructed micromodules are assembled into engineered biological tissues with r...

    Authors: Wenzhi Song, Lanlan Zhao, Yuqi Gao, Chunyu Han, Shengrui Gao, Min Guo, Jianfei Bai, Liqiang Wang, Wanzhong Yin, Feng Wu and Peibiao Zhang
    Citation: Journal of Biological Engineering 2023 17:43
  20. Cardiac tissue engineering (CTE) is a promising way for the restoration of injured cardiac tissue in the healthcare system. The development of biodegradable scaffolds with appropriate chemical, electrical, mec...

    Authors: Solmaz Saghebasl, Abbas Nobakht, Hesam Saghebasl, Sanya Hayati, Ozra Naturi and Reza Rahbarghazi
    Citation: Journal of Biological Engineering 2023 17:42
  21. Currently, breast carcinoma is the most common form of malignancy and the main cause of cancer mortality in women worldwide. The metastasis of cancer cells from the primary tumor site to other organs in the bo...

    Authors: Mohammad Kamalabadi Farahani, Maliheh Gharibshahian, Alireza Rezvani and Ahmad Vaez
    Citation: Journal of Biological Engineering 2023 17:41
  22. The ability to control neuronal mobility and organization is of great importance in developing neuronal interfaces and novel therapeutic approaches. An emerging promising method is the manipulation of neuronal...

    Authors: Dafna Rivka Levenberg, Eli Varon, Ganit Indech, Tal Ben Uliel, Lidor Geri, Amos Sharoni and Orit Shefi
    Citation: Journal of Biological Engineering 2023 17:40
  23. Skin is the largest organ of the human body. It plays a vital role as the body’s first barrier: stopping chemical, radiological damage and microbial invasion. The importance of skin to the human body can never...

    Authors: Chengzhi Liang, Jing He, Yuan Cao, Guoming Liu, Chengdong Zhang, Zhiping Qi, Chuan Fu and Yanling Hu
    Citation: Journal of Biological Engineering 2023 17:39
  24. To evaluate shear stress influence on ex vivo expansion of hematopoietic cell lineages for clinical application, in this study, human pro-monocytic cell (namely U937 cell line) was selected as a hematopoietic ...

    Authors: Sofia Mohseni, Ali Baradar Khoshfetrat, Reza Rahbarghazi, Shahla Khodabakhshaghdam and Leila Shafiei Kaleybar
    Citation: Journal of Biological Engineering 2023 17:38
  25. Thrombosis is a common cause of vascular prosthesis failure. Antibody coating of prostheses to capture circulating endothelial progenitor cells to aid endothelialization on the device surface appears a promisi...

    Authors: Qiuwang Zhang, Sebastian Duncan, Daniel A. Szulc, Charles de Mestral and Michael JB Kutryk
    Citation: Journal of Biological Engineering 2023 17:37
  26. The basic idea behind the use of 3-dimensional (3D) tools in biomedical research is the assumption that the structures under study will perform at the best in vitro if cultivated in an environment that is as s...

    Authors: Fatina Siwczak, Charlotte Hiller, Helga Pfannkuche and Marlon R. Schneider
    Citation: Journal of Biological Engineering 2023 17:36
  27. The freeze-thaw (F/T) method is commonly employed during the processing and handling of drug substances to enhance their chemical and physical stability and obtain pharmaceutical applications such as hydrogels...

    Authors: Sergio A. Bernal-Chávez, Alejandra Romero-Montero, Héctor Hernández-Parra, Sheila I. Peña-Corona, María L. Del Prado-Audelo, Sergio Alcalá-Alcalá, Hernán Cortés, Lashyn Kiyekbayeva, Javad Sharifi-Rad and Gerardo Leyva-Gómez
    Citation: Journal of Biological Engineering 2023 17:35
  28. Multiple myeloma (MM) is the second most common hematologic neoplasm which is characterized by proliferation and infiltration of plasmatic cells in the bone marrow. Currently, MM is considered incurable due to...

    Authors: Josep Escrivá-Fernández, Cristina Cueto-Ureña, Amalia Solana-Orts, Elisa Lledó, Begoña Ballester-Lurbe and Enric Poch
    Citation: Journal of Biological Engineering 2023 17:34
  29. Norovirus is a common pathogen that causes foodborne outbreaks every year and the increasing number of deaths caused by it has become a substantial concern in both developed and underdeveloped countries. To da...

    Authors: Abdulhakeem Alzahrani, Tawfiq Alsulami, Ahmad Mohammad Salamatullah and Syed Rahin Ahmed
    Citation: Journal of Biological Engineering 2023 17:33
  30. Non-involuting congenital hemangiomas (NICHs) are fully formed vascular tumors at birth with distinctive clinical, radiologic, and histopathological profiles. In the literature, there is no effective therapy s...

    Authors: Haoche Wei, Yanan Li, Li Li, Qian Hu, Mingsong Shi, Linbo Cheng, Xile Jiang, Yanting Zhou, Siyuan Chen, Yi Ji and Lijuan Chen
    Citation: Journal of Biological Engineering 2023 17:32
  31. To produce viral vaccines, avian cell lines are interesting alternatives to replace the egg-derived processes for viruses that do not grow well on mammalian cells. The avian suspension cell line DuckCelt®-T17 was...

    Authors: Valentine Tingaud, Claire Bordes, Eyad Al Mouazen, Claudia Cogné, Marie-Alexandrine Bolzinger and Philippe Lawton
    Citation: Journal of Biological Engineering 2023 17:31
  32. The main commercially available methods for detecting small molecules of mycotoxins in traditional Chinese medicine (TCM) and functional foods are enzyme-linked immunosorbent assay and mass spectrometry. Regar...

    Authors: Yu-Ching Lee, Gar-Hwa Lai, Tsai-Yu Lin, Tien-Sheng Tseng, Tsung-Hsun Tsai, Wang-Chuan Chen, Cheng-Chung Lee and Keng-Chang Tsai
    Citation: Journal of Biological Engineering 2023 17:30
  33. The porcine epidemic diarrhea virus (PEDV) represents a major health issue for piglets worldwide and does significant damage to the pork industry. Thus, new therapeutic approaches are urgently needed to manage...

    Authors: Rajesh Kumar Pathak, Won-Il Kim and Jun-Mo Kim
    Citation: Journal of Biological Engineering 2023 17:29
  34. Early diagnosis of Pancreatic Ductal Adenocarcinoma (PDAC) is the main key to surviving cancer patients. Urine proteomic biomarkers which are creatinine, LYVE1, REG1B, and TFF1 present a promising non-invasive...

    Authors: Mohamed Esmail Karar, Nawal El-Fishawy and Marwa Radad
    Citation: Journal of Biological Engineering 2023 17:28
  35. Utilizing both medium enrichment and a thermos-responsive substrate to maintain the cell-to-cell junctions and extracellular matrix (ECM) intact, cell sheet technology has emerged as a ground-breaking approach...

    Authors: Sevil Vaghefi Moghaddam, Fatemeh Abedi, Hajie Lotfi, Roya Salehi, Abolfazl Barzegar, Mohamadreza Baghaban Eslaminejad, Mostafa Khalili and Effat Alizadeh
    Citation: Journal of Biological Engineering 2023 17:27
  36. Recent advancements in additive manufacturing have made 3D design a desirable skill in combating the historically slow development of biomedical products. Due to the broad applicability of additive manufactur...

    Authors: Mary S. Jia, Raj R. Rao and Mostafa Elsaadany
    Citation: Journal of Biological Engineering 2023 17:26
  37. Human induced pluripotent stem cells (hiPSCs) provide an in vitro system to identify the impact of cell behavior on the earliest stages of cell fate specification during human development. Here, we developed a...

    Authors: Mee-Hae Kim, Masaki Kuroda, Ding Ke, Naruchit Thanuthanakhun and Masahiro Kino-oka
    Citation: Journal of Biological Engineering 2023 17:25
  38. Monoclonal antibodies are essential in life science research and developing antibody drugs and test drugs. Various methods have been developed to obtain monoclonal antibodies, among which hybridoma technology ...

    Authors: Atsumi Sakaguchi, Yoichiro Tanaka, Eiki Shoji, Teppei Takeshima, Rina Sakamaki, Takao Matsuba and Yasuyuki Kurihara
    Citation: Journal of Biological Engineering 2023 17:24
  39. Ischemic niche can promote follicular atresia following the transplantation of cryopreserved/thawed ovaries to the heterotopic sites. Thus, the promotion of blood supply is an effective strategy to inhibit/red...

    Authors: Melika Izadpanah, Azizeh Rahmani Del Bakhshayesh, Zahra Bahroudi, Abbas Majdi Seghinsara, Rahim Beheshti, Mahdi Mahdipour, Mahsa Rezaii Zarnaghi, Parisa Hassanpour, Narges Mardi, Reza Rahbarghazi and Ali Abedelahi
    Citation: Journal of Biological Engineering 2023 17:23
  40. Alzheimer’s disease (AD) represents one of the most common and debilitating neurodegenerative disorders. By the end of 2040, AD patients might reach 11.2 million in the USA, around 70% higher than 2022, with s...

    Authors: Francesca Donnaloja, Emma Limonta, Christian Mancosu, Francesco Morandi, Lucia Boeri, Diego Albani and Manuela Teresa Raimondi
    Citation: Journal of Biological Engineering 2023 17:22
  41. As an emerging science, tissue engineering and regenerative medicine focus on developing materials to replace, restore or improve organs or tissues and enhancing the cellular capacity to proliferate, migrate a...

    Authors: Samanta Castañeda-Rodríguez, Maykel González-Torres, Rosa María Ribas-Aparicio, María Luisa Del Prado‑Audelo, Gerardo Leyva‑Gómez, Eda Sönmez Gürer and Javad Sharifi‑Rad
    Citation: Journal of Biological Engineering 2023 17:21
  42. In this study, two types of polyurethane-based cylindrical multilayered grafts with internal diameters ≤ 6 mm were produced by the solution blow spinning (SBS) method. The main aim was to create layered-wall p...

    Authors: Iwona Łopianiak, Wiktoria Rzempołuch, Mehtap Civelek, Iwona Cicha, Tomasz Ciach and Beata A. Butruk-Raszeja
    Citation: Journal of Biological Engineering 2023 17:20
  43. Birch is a tree with a common occurrence in the environment and its organs are used in the form of herbal material. An important aspect of this study is birch pollen, which is a problem for allergy sufferers, ...

    Authors: Iwona Makuch-Pietraś, Dorota Grabek-Lejko, Anna Górka and Idalia Kasprzyk
    Citation: Journal of Biological Engineering 2023 17:19
  44. Bacterial colonisation on implantable device surfaces is estimated to cause more than half of healthcare-associated infections. The application of inorganic coatings onto implantable devices limits/prevents mi...

    Authors: Daniele Ghezzi, Marco Boi, Enrico Sassoni, Francesco Valle, Elena Giusto, Elisa Boanini, Nicola Baldini, Martina Cappelletti and Gabriela Graziani
    Citation: Journal of Biological Engineering 2023 17:18
  45. Epithelial-mesenchymal plasticity (EMP) involves bidirectional transitions between epithelial, mesenchymal and multiple intermediary hybrid epithelial/mesenchymal phenotypes. While the process of epithelial-me...

    Authors: Ayalur Raghu Subbalakshmi, Sarthak Sahoo, Prakruthi Manjunatha, Shaurya Goyal, Vignesh A Kasiviswanathan, Yeshwanth Mahesh, Soundharya Ramu, Isabelle McMullen, Jason A. Somarelli and Mohit Kumar Jolly
    Citation: Journal of Biological Engineering 2023 17:17
  46. Calcium oxalate (CaOx) stone disease is found worldwide. To explore the role of exosomes as a mediator of intercellular crosstalk during CaOx stone formation, we conducted this study, which may provide a new i...

    Authors: Yuanyuan Yang, Senyuan Hong, Qing Wang, Shaogang Wang and Yang Xun
    Citation: Journal of Biological Engineering 2023 17:16
  47. Needle-free jet injection (NFJI) systems enable a controlled and targeted delivery of drugs into skin tissue. However, a scarce understanding of their underlying mechanisms has been a major deterrent to the de...

    Authors: Abdul Mohizin, Jakir Hossain Imran, Kee Sung Lee and Jung Kyung Kim
    Citation: Journal of Biological Engineering 2023 17:15
  48. Ischemic vascular disease is a major healthcare problem. The keys to treatment lie in vascular regeneration and restoration of perfusion. However, current treatments cannot satisfy the need for vascular regene...

    Authors: Xinyue Chen, Wenlu Yu, Jing Zhang, Xiao Fan, Xiao Liu, Qi Liu, Su Pan, Richard A. F. Dixon, Pengyang Li, Peng Yu and Ao Shi
    Citation: Journal of Biological Engineering 2023 17:13