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  1. Silk glands are used by silkworms to spin silk fibers for making their cocoons. These have recently been regarded as bioreactor hosts for the cost-effective production of other valuable exogenous proteins and ...

    Authors: Sheng Xu, Feng Wang, Yuancheng Wang, Riyuan Wang, Kai Hou, Chi Tian, Yanting Ji, Qianqian Yang, Ping Zhao and Qingyou Xia

    Citation: Journal of Biological Engineering 2019 13:61

    Content type: Research

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  2. As a type of chronic autoimmune joint disease, rheumatoid arthritis (RA) is a disorder, characterized by a variety of physical symptoms as well as RA fibroblast-like synoviocyte (RA-FLS) proliferation. More re...

    Authors: Chun-Wang Zhang, Xia Wu, Dan Liu, Wei Zhou, Wei Tan, Yu-Xuan Fang, Yu Zhang, Yan-Qing Liu and Guo-Qing Li

    Citation: Journal of Biological Engineering 2019 13:60

    Content type: Research

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  3. The production of recombinant proteins in mammalian cell lines is one of the most important areas in biopharmaceutical industry. Viral transcriptional promoters are widely used to express recombinant proteins ...

    Authors: Roberto A Zúñiga, Matías Gutiérrez-González, Norberto Collazo, Pablo Hérnan Sotelo, Carolina H Ribeiro, Claudia Altamirano, Carmen Lorenzo, Juan Carlos Aguillón and María Carmen Molina

    Citation: Journal of Biological Engineering 2019 13:59

    Content type: Research

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  4. Traditional cancer therapies, such as surgery treatment, radiotherapy, and chemotherapy, often fail to completely eliminate tumor cells in an anaerobic microenvironment of tumor regions.

    Authors: Lian He, Huijun Yang, Jianli Tang, Zhudong Liu, Yiyan Chen, Binghua Lu, Haocheng He, Sijia Tang, Yunjun Sun, Fei Liu, Xuezhi Ding, Youming Zhang, Shengbiao Hu and Liqiu Xia

    Citation: Journal of Biological Engineering 2019 13:58

    Content type: Research

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  5. The purpose of this review is to assess the state-of-the-art fabrication methods, advances in genome editing, and the use of machine learning to shape the prospective growth in cardiac tissue engineering. Thos...

    Authors: Anh H. Nguyen, Paul Marsh, Lauren Schmiess-Heine, Peter J. Burke, Abraham Lee, Juhyun Lee and Hung Cao

    Citation: Journal of Biological Engineering 2019 13:57

    Content type: Review

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  6. Immunotoxins consisting of a toxin from bacteria or plants and a targeting module have been developed as potent anti-cancer therapeutics. The majority of them, especially those in preclinical or clinical testi...

    Authors: Byeong Sung Lee, Yumi Lee, Jisoo Park, Bo Seok Jeong, Migyeong Jo, Sang Taek Jung and Tae Hyeon Yoo

    Citation: Journal of Biological Engineering 2019 13:56

    Content type: Research

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  7. Engineered living materials (ELMs) are an exciting new frontier, where living organisms create highly functional materials. In particular, protein ELMs have the advantage that their properties can be manipulat...

    Authors: Daniel T. Peters, Helen Waller, Mark A. Birch and Jeremy H. Lakey

    Citation: Journal of Biological Engineering 2019 13:54

    Content type: Research

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  8. A transcriptional reporter is the key component in bacterial biosensors which are employed to monitor the induction or repression of a reporter gene corresponding to environmental change. Interaction of a tran...

    Authors: Xingjuan Chen, Xin Jiang, Cuijuan Tie, Jinnon Yoo, Yan Wang, Meiying Xu, Guoping Sun, Jun Guo and Xianqiang Li

    Citation: Journal of Biological Engineering 2019 13:53

    Content type: Research

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  9. Biofilters are soil-plant based passive stormwater treatment systems which demonstrate promising, although inconsistent, removal of faecal microorganisms. Antimicrobial-producing plants represent a safe, inexp...

    Authors: P. Galbraith, R. Henry and D. T. McCarthy

    Citation: Journal of Biological Engineering 2019 13:52

    Content type: Research

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  10. We herein describe a personal glucose meter (PGM)-based method for a label-free and washing-free determination of alkaline phosphatase (ALP) activity, which relies on the cascade enzymatic reactions promoted b...

    Authors: Jun Ki Ahn, Hyo Yong Kim, Chang Yeol Lee, Ki Soo Park and Hyun Gyu Park

    Citation: Journal of Biological Engineering 2019 13:51

    Content type: Letter to the Editor

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  11. Osteoporosis (OP) is a condition featured by bone mass loss and bone tissue microarchitectural alterations due to impaired tissue homeostasis favoring excessive bone resorption versus deposition. The trigger o...

    Authors: Shaojin Liu, Hongxing Huang, Shuang Chai, Hewei Wei, Jiachun Huang and Lei Wan

    Citation: Journal of Biological Engineering 2019 13:50

    Content type: Research

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  12. Myocardial infarction (MI) is a common cause of mortality in people. Mesenchymal stem cell (MSC) has been shown to exert therapeutic potential to treat myocardial infarction (MI). However, in patients with dia...

    Authors: Xin Meng, Minjuan Zheng, Ming Yu, Wei Bai, Lei Zuo, Xin Bu, Yi Liu, Linying Xia, Jing Hu, Liwen Liu and Jianping Li

    Citation: Journal of Biological Engineering 2019 13:49

    Content type: Research

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  13. Traditional therapeutics and vaccines represent the bedrock of modern medicine, where isolated biochemical molecules or designed proteins have led to success in treating and preventing diseases. However, sever...

    Authors: Max Levy, Partha P. Chowdhury and Prashant Nagpal

    Citation: Journal of Biological Engineering 2019 13:48

    Content type: Review

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  14. Hospital wastewater is commonly polluted with high loads of pharmaceutically active compounds, which pass through wastewater treatment plants (WWTPs) and end up in water bodies, posing ecological and health ri...

    Authors: Josep Anton Mir-Tutusaus, Eloi Parladé, Marta Villagrasa, Damià Barceló, Sara Rodríguez-Mozaz, Maira Martínez-Alonso, Núria Gaju, Montserrat Sarrà and Glòria Caminal

    Citation: Journal of Biological Engineering 2019 13:47

    Content type: Research

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  15. Tumor numerical models have been used to quantify solute transport with a single capillary embedded in an infinite tumor expanse, but measurements from different mammalian tumors suggest that a tissue containi...

    Authors: Sreyashi Chakraborty, Alican Ozkan, Marissa Nichole Rylander, Wendy A. Woodward and Pavlos Vlachos

    Citation: Journal of Biological Engineering 2019 13:46

    Content type: Research

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  16. More than five million Americans suffer from heart valve disease annually, a condition that worsens cardiac function and gradually leads to heart failure if appropriate treatment is not performed on time. Curr...

    Authors: Ngoc Thien Lam, Ishita Tandon and Kartik Balachandran

    Citation: Journal of Biological Engineering 2019 13:45

    Content type: Research

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  17. Coumarins play roles in many biological processes. Angelica decursiva is one of the major sources of coumarins in China. Due to increasing demand for coumarins in the marketplace, traditional extraction from plan...

    Authors: Yucheng Zhao, Xiangyun Jian, Jialin Wu, Wanchun Huang, Chuanlong Huang, Jun Luo and Lingyi Kong

    Citation: Journal of Biological Engineering 2019 13:44

    Content type: Research

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  18. Metabolic labeling of proteins with non-canonical amino acids (ncAAs) provides unique bioorthogonal chemical groups during de novo synthesis by taking advantage of both endogenous and heterologous protein synt...

    Authors: Aya M. Saleh, Kristen M. Wilding, Sarah Calve, Bradley C. Bundy and Tamara L. Kinzer-Ursem

    Citation: Journal of Biological Engineering 2019 13:43

    Content type: Review

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  19. Cephalometric analysis is used to evaluate facial growth, to study the anatomical relationships within the face. Cephalometric assessment is based on 2D radiographic images, either the sagittal or coronal plan...

    Authors: Manuel Pinheiro, Xinhui Ma, Michael J. Fagan, Grant T. McIntyre, Ping Lin, Gautham Sivamurthy and Peter A. Mossey

    Citation: Journal of Biological Engineering 2019 13:42

    Content type: Methodology

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  20. Olfactory ensheathing cell (OEC) transplantation is emerging as a promising therapy for spinal cord injuries. However, outcomes are inconsistent, and the method needs improvement. Currently, cells are injected...

    Authors: Lachlan J. Beckingham, Michael Todorovic, Johana Tello Velasquez, Marie-Laure Vial, Mo Chen, Jenny A. K. Ekberg and James A. St John

    Citation: Journal of Biological Engineering 2019 13:41

    Content type: Research

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  21. The application of synthetic modified messenger RNA (mRNA) is a promising approach for the treatment of a variety of diseases and vaccination. In the past few years, different modifications of synthetic mRNA w...

    Authors: Tatjana Michel, Sonia Golombek, Heidrun Steinle, Ludmilla Hann, Ana Velic, Boris Macek, Stefanie Krajewski, Christian Schlensak, Hans Peter Wendel and Meltem Avci-Adali

    Citation: Journal of Biological Engineering 2019 13:40

    Content type: Research

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  22. The availability of renewable energy technologies is increasing dramatically across the globe thanks to their growing maturity. However, large scale electrical energy storage and retrieval will almost certainl...

    Authors: Farshid Salimijazi, Erika Parra and Buz Barstow

    Citation: Journal of Biological Engineering 2019 13:38

    Content type: Review

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  23. In the original version of this article [1], published on 18 December 2018, there was 1 incorrect author name.

    Authors: Alessio Biagioni, Anna Laurenzana, Francesca Margheri, Anastasia Chillà, Gabriella Fibbi and Mario Del Rosso

    Citation: Journal of Biological Engineering 2019 13:37

    Content type: Publisher Correction

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    The original article was published in Journal of Biological Engineering 2018 12:33

  24. The luminal surface of the small intestine is composed of a monolayer of cells overlying a lamina propria comprised of extracellular matrix (ECM) proteins. The ECM provides a porous substrate critical for nutrien...

    Authors: Jennifer E. Speer, Dulan B. Gunasekara, Yuli Wang, John K. Fallon, Peter J. Attayek, Philip C. Smith, Christopher E. Sims and Nancy L. Allbritton

    Citation: Journal of Biological Engineering 2019 13:36

    Content type: Research

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  25. CRISPR/Cas9 system is a powerful tool for knocking out genes in cells. However, genes essential for cell survival cannot be directly knocked out. Traditionally, generation of conditional knockout cells require...

    Authors: Bei Wang, Zishi Wang, Daqi Wang, Baolong Zhang, Sang-Ging Ong, Mingqing Li, Wenqiang Yu and Yongming Wang

    Citation: Journal of Biological Engineering 2019 13:35

    Content type: Research

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  26. The adoptive transfer of human T cells or genetically-engineered T cells with cancer-targeting receptors has shown tremendous promise for eradicating tumors in clinical trials. The objective of this study was ...

    Authors: Jianfa Ou, Yingnan Si, Yawen Tang, Grace E. Salzer, Yun Lu, Seulhee Kim, Hongwei Qin, Lufang Zhou and Xiaoguang Liu

    Citation: Journal of Biological Engineering 2019 13:34

    Content type: Research

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  27. Glycine cleavage system (GCS) plays a key role in one-carbon (C1) metabolism related to the biosynthesis of a number of key intermediates with significance in both biomedicine and biotechnology. Despite extens...

    Authors: Xinyi Zhang, Mei Li, Yingying Xu, Jie Ren and An-Ping Zeng

    Citation: Journal of Biological Engineering 2019 13:32

    Content type: Research

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  28. Extracellular vesicles (EVs) are membrane-bound phospholipid vesicles actively secreted by all cells. As they carry specific markers expressed by their parental cells, EVs are utilized to identify specific cel...

    Authors: Kalishwaralal Kalimuthu, Woo Young Kwon and Ki Soo Park

    Citation: Journal of Biological Engineering 2019 13:31

    Content type: Research

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  29. Glycolate is an important α-hydroxy carboxylic acid widely used in industrial and consumer applications. The production of glycolate from glucose in Escherichia coli is generally carried out by glycolysis and gly...

    Authors: Kangjia Zhu, Guohui Li, Ren Wei, Yin Mao, Yunying Zhao, Aiyong He, Zhonghu Bai and Yu Deng

    Citation: Journal of Biological Engineering 2019 13:30

    Content type: Research

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  30. In vitro three-dimensional (3D) microengineered tissue models have been the recent focus of pathophysiological studies, particularly in the field of cardiovascular research. These models, as classified by 3D b...

    Authors: Jaimeson Veldhuizen, Raymond Q. Migrino and Mehdi Nikkhah

    Citation: Journal of Biological Engineering 2019 13:29

    Content type: Review

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  31. Biliverdin, a prospective recyclable antioxidant and one of the most important precursors for optogenetics, has received growing attention. Biliverdin is currently produced by oxidation of bilirubin from mamma...

    Authors: Jiho Seok, Young Jin Ko, Myeong-Eun Lee, Jeong Eun Hyeon and Sung Ok Han

    Citation: Journal of Biological Engineering 2019 13:28

    Content type: Research

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  32. Owing to the thermal instability and low affinity of BlaR-CTD to some β-lactams, the receptor assay based on BlaR-CTD is limited in the detection of abundant variety of drugs and the result is often unstable. ...

    Authors: Jianan Ning, Saeed Ahmed, Guyue Cheng, Ting Chen, Yulian Wang, Dapeng Peng and Zonghui Yuan

    Citation: Journal of Biological Engineering 2019 13:27

    Content type: Research

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  33. Capillaries within the microcirculation are essential for oxygen delivery and nutrient/waste exchange, among other critical functions. Microvascular bioengineering approaches have sought to recapitulate many k...

    Authors: Huaning Zhao and John C. Chappell

    Citation: Journal of Biological Engineering 2019 13:26

    Content type: Review

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  34. Equine mesenchymal stromal cells (MSCs) are increasingly investigated for their clinical therapeutic utility. Such cell-based treatments can require cell numbers in the millions or billions, with conventional ...

    Authors: Erin L. Roberts, Tiffany Dang, Sarah I. M. Lepage, Amir Hamed Alizadeh, Tylor Walsh, Thomas G. Koch and Michael S. Kallos

    Citation: Journal of Biological Engineering 2019 13:25

    Content type: Research

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  35. Gamma (γ)-Aminobutyric acid (GABA) as a bioactive compound is used extensively in functional foods, pharmaceuticals and agro-industry. It can be biosynthesized via decarboxylation of monosodium glutamate (MSG)...

    Authors: Haina Yuan, Hongbo Wang, Ozkan Fidan, Yong Qin, Gongnian Xiao and Jixun Zhan

    Citation: Journal of Biological Engineering 2019 13:24

    Content type: Research

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  36. Partially acetylated chito-oligosaccharides (paCOS) have a variety of potential applications in different fields, but to harness their benefits, pure paCOS or well-defined paCOS mixtures are essential. For exa...

    Authors: David Gercke, Eva K. Regel, Ratna Singh and Bruno M. Moerschbacher

    Citation: Journal of Biological Engineering 2019 13:23

    Content type: Research

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  37. Various hepatic models mimicking liver lobules have been investigated to evaluate the potential hepatotoxic effects of chemicals and drugs, but in vitro hepatic models of zonal hepatotoxicity have not yet been...

    Authors: Jaehwan Ahn, Jun-Ho Ahn, Seokjoo Yoon, Yoon Sung Nam, Mi-Young Son and Jung-Hwa Oh

    Citation: Journal of Biological Engineering 2019 13:22

    Content type: Research

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  38. Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1), a long non coding RNA (lncRNA) present in serum, is an important biomarker for detecting hepatocellular carcinoma (HCC). However, there are some...

    Authors: Fei Liu, Tao Li, Liqun Zhang, Guiming Xiang, Dongneng Jiang, Dianji Tu, Linlin Liu, Yi Li, Chang Liu and Xiaoyun Pu

    Citation: Journal of Biological Engineering 2019 13:21

    Content type: Research

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  39. Frame-shifted genes results in non-functional peptides. Because of this complete loss of function, frame-shifted genes have never been used in constructing synthetic gene circuits.

    Authors: Kathakali Sarkar, Sayak Mukhopadhyay, Deepro Bonnerjee, Rajkamal Srivastava and Sangram Bagh

    Citation: Journal of Biological Engineering 2019 13:20

    Content type: Research

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  40. Broad translational success of RNA interference (RNAi) technology depends on the development of effective delivery approaches. To that end, researchers have developed a variety of strategies, including chemica...

    Authors: Alex Eli Pottash, Christopher Kuffner, Madeleine Noonan-Shueh and Steven M. Jay

    Citation: Journal of Biological Engineering 2019 13:19

    Content type: Review

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  41. Fed-batch conditions are advantageous for industrial cultivations as they avoid unfavorable phenomena appearing in batch cultivations. Those are for example the formation of overflow metabolites, catabolite re...

    Authors: T. Keil, B. Dittrich, C. Lattermann, T. Habicher and J. Büchs

    Citation: Journal of Biological Engineering 2019 13:18

    Content type: Research

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  42. Cardiac fibrosis is the most common pathway of many cardiac diseases. To date, there has been no suitable in vitro cardiac fibrosis model that could sufficiently mimic the complex environment of the human hear...

    Authors: Mi-Ok Lee, Kwang Bo Jung, Seong-Jae Jo, Sung-Ae Hyun, Kyoung-Sik Moon, Joung-Wook Seo, Sang-Heon Kim and Mi-Young Son

    Citation: Journal of Biological Engineering 2019 13:15

    Content type: Research

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