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  1. Coumarins play roles in many biological processes. Angelica decursiva is one of the major sources of coumarins in China. Due to increasing demand for coumarins in the marketplace, traditional extraction from plan...

    Authors: Yucheng Zhao, Xiangyun Jian, Jialin Wu, Wanchun Huang, Chuanlong Huang, Jun Luo and Lingyi Kong

    Citation: Journal of Biological Engineering 2019 13:44

    Content type: Research

    Published on:

  2. Metabolic labeling of proteins with non-canonical amino acids (ncAAs) provides unique bioorthogonal chemical groups during de novo synthesis by taking advantage of both endogenous and heterologous protein synt...

    Authors: Aya M. Saleh, Kristen M. Wilding, Sarah Calve, Bradley C. Bundy and Tamara L. Kinzer-Ursem

    Citation: Journal of Biological Engineering 2019 13:43

    Content type: Review

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  3. Cephalometric analysis is used to evaluate facial growth, to study the anatomical relationships within the face. Cephalometric assessment is based on 2D radiographic images, either the sagittal or coronal plan...

    Authors: Manuel Pinheiro, Xinhui Ma, Michael J. Fagan, Grant T. McIntyre, Ping Lin, Gautham Sivamurthy and Peter A. Mossey

    Citation: Journal of Biological Engineering 2019 13:42

    Content type: Methodology

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  4. Olfactory ensheathing cell (OEC) transplantation is emerging as a promising therapy for spinal cord injuries. However, outcomes are inconsistent, and the method needs improvement. Currently, cells are injected...

    Authors: Lachlan J. Beckingham, Michael Todorovic, Johana Tello Velasquez, Marie-Laure Vial, Mo Chen, Jenny A. K. Ekberg and James A. St John

    Citation: Journal of Biological Engineering 2019 13:41

    Content type: Research

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  5. The application of synthetic modified messenger RNA (mRNA) is a promising approach for the treatment of a variety of diseases and vaccination. In the past few years, different modifications of synthetic mRNA w...

    Authors: Tatjana Michel, Sonia Golombek, Heidrun Steinle, Ludmilla Hann, Ana Velic, Boris Macek, Stefanie Krajewski, Christian Schlensak, Hans Peter Wendel and Meltem Avci-Adali

    Citation: Journal of Biological Engineering 2019 13:40

    Content type: Research

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  6. The availability of renewable energy technologies is increasing dramatically across the globe thanks to their growing maturity. However, large scale electrical energy storage and retrieval will almost certainl...

    Authors: Farshid Salimijazi, Erika Parra and Buz Barstow

    Citation: Journal of Biological Engineering 2019 13:38

    Content type: Review

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  7. In the original version of this article [1], published on 18 December 2018, there was 1 incorrect author name.

    Authors: Alessio Biagioni, Anna Laurenzana, Francesca Margheri, Anastasia Chillà, Gabriella Fibbi and Mario Del Rosso

    Citation: Journal of Biological Engineering 2019 13:37

    Content type: Publisher Correction

    Published on:

    The original article was published in Journal of Biological Engineering 2018 12:33

  8. The luminal surface of the small intestine is composed of a monolayer of cells overlying a lamina propria comprised of extracellular matrix (ECM) proteins. The ECM provides a porous substrate critical for nutrien...

    Authors: Jennifer E. Speer, Dulan B. Gunasekara, Yuli Wang, John K. Fallon, Peter J. Attayek, Philip C. Smith, Christopher E. Sims and Nancy L. Allbritton

    Citation: Journal of Biological Engineering 2019 13:36

    Content type: Research

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  9. CRISPR/Cas9 system is a powerful tool for knocking out genes in cells. However, genes essential for cell survival cannot be directly knocked out. Traditionally, generation of conditional knockout cells require...

    Authors: Bei Wang, Zishi Wang, Daqi Wang, Baolong Zhang, Sang-Ging Ong, Mingqing Li, Wenqiang Yu and Yongming Wang

    Citation: Journal of Biological Engineering 2019 13:35

    Content type: Research

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  10. The adoptive transfer of human T cells or genetically-engineered T cells with cancer-targeting receptors has shown tremendous promise for eradicating tumors in clinical trials. The objective of this study was ...

    Authors: Jianfa Ou, Yingnan Si, Yawen Tang, Grace E. Salzer, Yun Lu, Seulhee Kim, Hongwei Qin, Lufang Zhou and Xiaoguang Liu

    Citation: Journal of Biological Engineering 2019 13:34

    Content type: Research

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  11. Glycine cleavage system (GCS) plays a key role in one-carbon (C1) metabolism related to the biosynthesis of a number of key intermediates with significance in both biomedicine and biotechnology. Despite extens...

    Authors: Xinyi Zhang, Mei Li, Yingying Xu, Jie Ren and An-Ping Zeng

    Citation: Journal of Biological Engineering 2019 13:32

    Content type: Research

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  12. Extracellular vesicles (EVs) are membrane-bound phospholipid vesicles actively secreted by all cells. As they carry specific markers expressed by their parental cells, EVs are utilized to identify specific cel...

    Authors: Kalishwaralal Kalimuthu, Woo Young Kwon and Ki Soo Park

    Citation: Journal of Biological Engineering 2019 13:31

    Content type: Research

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  13. Glycolate is an important α-hydroxy carboxylic acid widely used in industrial and consumer applications. The production of glycolate from glucose in Escherichia coli is generally carried out by glycolysis and gly...

    Authors: Kangjia Zhu, Guohui Li, Ren Wei, Yin Mao, Yunying Zhao, Aiyong He, Zhonghu Bai and Yu Deng

    Citation: Journal of Biological Engineering 2019 13:30

    Content type: Research

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  14. In vitro three-dimensional (3D) microengineered tissue models have been the recent focus of pathophysiological studies, particularly in the field of cardiovascular research. These models, as classified by 3D b...

    Authors: Jaimeson Veldhuizen, Raymond Q. Migrino and Mehdi Nikkhah

    Citation: Journal of Biological Engineering 2019 13:29

    Content type: Review

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  15. Biliverdin, a prospective recyclable antioxidant and one of the most important precursors for optogenetics, has received growing attention. Biliverdin is currently produced by oxidation of bilirubin from mamma...

    Authors: Jiho Seok, Young Jin Ko, Myeong-Eun Lee, Jeong Eun Hyeon and Sung Ok Han

    Citation: Journal of Biological Engineering 2019 13:28

    Content type: Research

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  16. Owing to the thermal instability and low affinity of BlaR-CTD to some β-lactams, the receptor assay based on BlaR-CTD is limited in the detection of abundant variety of drugs and the result is often unstable. ...

    Authors: Jianan Ning, Saeed Ahmed, Guyue Cheng, Ting Chen, Yulian Wang, Dapeng Peng and Zonghui Yuan

    Citation: Journal of Biological Engineering 2019 13:27

    Content type: Research

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  17. Capillaries within the microcirculation are essential for oxygen delivery and nutrient/waste exchange, among other critical functions. Microvascular bioengineering approaches have sought to recapitulate many k...

    Authors: Huaning Zhao and John C. Chappell

    Citation: Journal of Biological Engineering 2019 13:26

    Content type: Review

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  18. Equine mesenchymal stromal cells (MSCs) are increasingly investigated for their clinical therapeutic utility. Such cell-based treatments can require cell numbers in the millions or billions, with conventional ...

    Authors: Erin L. Roberts, Tiffany Dang, Sarah I. M. Lepage, Amir Hamed Alizadeh, Tylor Walsh, Thomas G. Koch and Michael S. Kallos

    Citation: Journal of Biological Engineering 2019 13:25

    Content type: Research

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  19. Gamma (γ)-Aminobutyric acid (GABA) as a bioactive compound is used extensively in functional foods, pharmaceuticals and agro-industry. It can be biosynthesized via decarboxylation of monosodium glutamate (MSG)...

    Authors: Haina Yuan, Hongbo Wang, Ozkan Fidan, Yong Qin, Gongnian Xiao and Jixun Zhan

    Citation: Journal of Biological Engineering 2019 13:24

    Content type: Research

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  20. Partially acetylated chito-oligosaccharides (paCOS) have a variety of potential applications in different fields, but to harness their benefits, pure paCOS or well-defined paCOS mixtures are essential. For exa...

    Authors: David Gercke, Eva K. Regel, Ratna Singh and Bruno M. Moerschbacher

    Citation: Journal of Biological Engineering 2019 13:23

    Content type: Research

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  21. Various hepatic models mimicking liver lobules have been investigated to evaluate the potential hepatotoxic effects of chemicals and drugs, but in vitro hepatic models of zonal hepatotoxicity have not yet been...

    Authors: Jaehwan Ahn, Jun-Ho Ahn, Seokjoo Yoon, Yoon Sung Nam, Mi-Young Son and Jung-Hwa Oh

    Citation: Journal of Biological Engineering 2019 13:22

    Content type: Research

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  22. Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1), a long non coding RNA (lncRNA) present in serum, is an important biomarker for detecting hepatocellular carcinoma (HCC). However, there are some...

    Authors: Fei Liu, Tao Li, Liqun Zhang, Guiming Xiang, Dongneng Jiang, Dianji Tu, Linlin Liu, Yi Li, Chang Liu and Xiaoyun Pu

    Citation: Journal of Biological Engineering 2019 13:21

    Content type: Research

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  23. Frame-shifted genes results in non-functional peptides. Because of this complete loss of function, frame-shifted genes have never been used in constructing synthetic gene circuits.

    Authors: Kathakali Sarkar, Sayak Mukhopadhyay, Deepro Bonnerjee, Rajkamal Srivastava and Sangram Bagh

    Citation: Journal of Biological Engineering 2019 13:20

    Content type: Research

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  24. Broad translational success of RNA interference (RNAi) technology depends on the development of effective delivery approaches. To that end, researchers have developed a variety of strategies, including chemica...

    Authors: Alex Eli Pottash, Christopher Kuffner, Madeleine Noonan-Shueh and Steven M. Jay

    Citation: Journal of Biological Engineering 2019 13:19

    Content type: Review

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  25. Fed-batch conditions are advantageous for industrial cultivations as they avoid unfavorable phenomena appearing in batch cultivations. Those are for example the formation of overflow metabolites, catabolite re...

    Authors: T. Keil, B. Dittrich, C. Lattermann, T. Habicher and J. Büchs

    Citation: Journal of Biological Engineering 2019 13:18

    Content type: Research

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  26. Cardiac fibrosis is the most common pathway of many cardiac diseases. To date, there has been no suitable in vitro cardiac fibrosis model that could sufficiently mimic the complex environment of the human hear...

    Authors: Mi-Ok Lee, Kwang Bo Jung, Seong-Jae Jo, Sung-Ae Hyun, Kyoung-Sik Moon, Joung-Wook Seo, Sang-Heon Kim and Mi-Young Son

    Citation: Journal of Biological Engineering 2019 13:15

    Content type: Research

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  27. Detecting the arbitrary movements of fast-moving insects under field conditions is notoriously difficult because existing technologies are limited by issues of size, weight, range and cost. Here, we establish ...

    Authors: Sarah E. Barlow, Mark A. O’Neill and Bruce M. Pavlik

    Citation: Journal of Biological Engineering 2019 13:13

    Content type: Letters to the Editor

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  28. Digitalization of health care practices is substantially manifesting itself as an effective tool to diagnose and rectify complex cardiovascular abnormalities. For cardiovascular abnormalities, precise non-inva...

    Authors: Rajat Vashistha, Prasoon Kumar, Arun Kumar Dangi, Naveen Sharma, Deepak Chhabra and Pratyoosh Shukla

    Citation: Journal of Biological Engineering 2019 13:12

    Content type: Review

    Published on:

  29. Erythromycin A (Er-A) produced by the actinomycete Saccharopolyspora erythraea is an important antibiotic extensively used in human medicine. Dissecting of transcriptional regulators and their target genes associ...

    Authors: Hang Wu, Zuling Chu, Wanxiang Zhang, Chi Zhang, Jingshu Ni, Heshi Fang, Yuhong Chen, Yansheng Wang, Lixin Zhang and Buchang Zhang

    Citation: Journal of Biological Engineering 2019 13:11

    Content type: Research

    Published on:

  30. ADAMTS13 (A disintegrin and metalloprotease with a thrombospondin type 1 motif 13) cleaves Von Willebrand factor (VWF) to regulate its size, thereby preventing aberrant platelet aggregation and thrombus. Defic...

    Authors: Shanshan Yu, Wang Liu, Jinhua Fang, Xiaozhong Shi, Jianhua Wu, Ying Fang and Jiangguo Lin

    Citation: Journal of Biological Engineering 2019 13:9

    Content type: Research

    Published on:

  31. The automation of modular cloning methodologies permits the assembly of many genetic designs. Utilising characterised biological parts aids in the design and redesign of genetic pathways. The characterisation ...

    Authors: Kealan Exley, Christopher Robert Reynolds, Lorna Suckling, Soo Mei Chee, Argyro Tsipa, Paul S. Freemont, David McClymont and Richard Ian Kitney

    Citation: Journal of Biological Engineering 2019 13:8

    Content type: Methodology

    Published on:

  32. Cardiovascular disease and myocardial infarction are associated with high mortality and morbidity and a more effective treatment remains a major clinical need. The intramyocardial injection of biomaterials has...

    Authors: David J. Lee, Maria A. Cavasin, Adam J. Rocker, Danielle E. Soranno, Xianzhong Meng, Robin Shandas and Daewon Park

    Citation: Journal of Biological Engineering 2019 13:6

    Content type: Research

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  33. The research community is intent on harnessing increasingly complex biological building blocks. At present, cells represent a highly functional component for integration into higher order systems. In this revi...

    Authors: Kara A. Davis, Pei-Jung Wu, Calvin F. Cahall, Cong Li, Anuhya Gottipati and Brad J. Berron

    Citation: Journal of Biological Engineering 2019 13:5

    Content type: Review

    Published on:

  34. The onset of cancer metastasis is the defining event in cancer progression when the disease is considered lethal. The ability of metastatic cancer cells to stay dormant for extended time periods and reawaken a...

    Authors: Shreyas S. Rao, Raghu Vamsi Kondapaneni and Akshay A. Narkhede

    Citation: Journal of Biological Engineering 2019 13:3

    Content type: Review

    Published on:

  35. Metastatic recurrence is a major hurdle to overcome for successful control of cancer-associated death. Residual tumor cells in the primary site, or disseminated tumor cells in secondary sites, can lie in a dor...

    Authors: Shantanu Pradhan, John L. Sperduto, Cindy J. Farino and John H. Slater

    Citation: Journal of Biological Engineering 2018 12:37

    Content type: Review

    Published on:

  36. Angiogenesis is touted as a fundamental procedure in the regeneration and restoration of different tissues. The induction of de novo blood vessels seems to be vital to yield a successful cell transplantation r...

    Authors: Shirin Saberianpour, Morteza Heidarzadeh, Mohammad Hossein Geranmayeh, Hossein Hosseinkhani, Reza Rahbarghazi and Mohammad Nouri

    Citation: Journal of Biological Engineering 2018 12:36

    Content type: Review

    Published on:

  37. Cell-based therapy by transplantation of nucleus pulposus (NP) progenitor/notochordal cells has been proposed as a promising way to halt and reverse the progression of disc degeneration. Although some studies ...

    Authors: Zhuochao Liu, Zhiyong Zheng, Jin Qi, Jun Wang, Qi Zhou, Fangqiong Hu, Jing Liang, Changwei Li, Weibin Zhang and Xingkai Zhang

    Citation: Journal of Biological Engineering 2018 12:35

    Content type: Research

    Published on:

  38. Pectin is a rather complex and highly branched polysaccharide strengthening the plant cell wall. Thus, many different pectinases are required for an efficient microbial conversion of biomass waste streams with...

    Authors: Markus Jan Müller, Sarah Stachurski, Peter Stoffels, Kerstin Schipper, Michael Feldbrügge and Jochen Büchs

    Citation: Journal of Biological Engineering 2018 12:34

    Content type: Research

    Published on:

  39. CRISPR/Cas9 (Clustered Regularly Interspaced Short Palindromic Repeats) is today one of the most reliable method for gene-editing, supporting previous gene therapies technologies such as TALEN, Meganucleases a...

    Authors: Alessio Biagioni, Anna Laurenzana, Francesca Margheri, Anastasia Chillà, Gabriella Fibbi and Mario Del Rosso

    Citation: Journal of Biological Engineering 2018 12:33

    Content type: Review

    Published on:

    The Publisher Correction to this article has been published in Journal of Biological Engineering 2019 13:37

  40. The lymphatic system is a major circulatory system within the body, responsible for the transport of interstitial fluid, waste products, immune cells, and proteins. Compared to other physiological systems, the...

    Authors: Laura Alderfer, Alicia Wei and Donny Hanjaya-Putra

    Citation: Journal of Biological Engineering 2018 12:32

    Content type: Review

    Published on: