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  1. Content type: Research

    Imbalances in gene expression of a metabolic pathway can result in less-yield of the desired products. Several targets were intensively investigated to balance the gene expression, such as promoter, ribosome b...

    Authors: Shasha Zhang, Xuejin Zhao, Yong Tao and Chunbo Lou

    Citation: Journal of Biological Engineering 2015 9:23

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  2. Content type: Research

    In the field of biomedical engineering, many studies have focused on the possible applications of graphene and related nanomaterials due to their potential for use as scaffolds, coating materials and delivery ...

    Authors: Yong Cheol Shin, Jong Ho Lee, Min Jeong Kim, Suck Won Hong, Bongju Kim, Jung Keun Hyun, Yu Suk Choi, Jong-Chul Park and Dong-Wook Han

    Citation: Journal of Biological Engineering 2015 9:22

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  3. Content type: Research

    Cell migration is a vital process for growth and repair. In vitro migration assays, utilized to study cell migration, often rely on physical scraping of a cell monolayer to induce cell migration. The physical act...

    Authors: Kaitlyn R. Ammann, Katrina J. DeCook, Phat L. Tran, Valerie M. Merkle, Pak K. Wong and Marvin J. Slepian

    Citation: Journal of Biological Engineering 2015 9:19

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  4. Content type: Research

    The interaction of stem cells with their culture substrates is critical in controlling their fate and function. Declining stemness of adult-derived human mesenchymal stem cells (hMSCs) during in vitro expansion o...

    Authors: Lucas H. Hofmeister, Lino Costa, Daniel A. Balikov, Spencer W. Crowder, Alexander Terekhov, Hak-Joon Sung and William H. Hofmeister

    Citation: Journal of Biological Engineering 2015 9:18

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  5. Content type: Letters to the Editor

    There is a general assent on the key role of standards in Synthetic Biology. In two consecutive letters to this journal, suggestions on the assembly methods for the Registry of standard biological parts have b...

    Authors: Cristina Vilanova, Kristie Tanner, Pedro Dorado-Morales, Paula Villaescusa, Divya Chugani, Alba Frías, Ernesto Segredo, Xavier Molero, Marco Fritschi, Lucas Morales, Daniel Ramón, Carlos Peña, Juli Peretó and Manuel Porcar

    Citation: Journal of Biological Engineering 2015 9:17

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  6. Content type: Methodology

    Molecular cloning is an essential step in biological engineering. Methods involving megaprimer-based PCR of a whole plasmid are promising alternatives to the traditional restriction-ligation-based molecular cl...

    Authors: Pawel Jajesniak and Tuck Seng Wong

    Citation: Journal of Biological Engineering 2015 9:15

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  7. Content type: Methodology

    Directing cell behaviour using controllable, on-demand non-biochemical methods, such as electrical stimulation is an attractive area of research. While there exists much potential in exploring different modes ...

    Authors: Gordon Minru Xiong, Anh Tuan Do, Jun Kit Wang, Chee Leong Yeoh, Kiat Seng Yeo and Cleo Choong

    Citation: Journal of Biological Engineering 2015 9:14

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  8. Content type: Research

    Extensive native Jatropha curcas L. (Jatropha) crop areas have been planted in Central America marginal lands since 2008 as a non-edible prospective feedstock alternative to high-value, edible palm oil. Jatropha ...

    Authors: Francisco Bueso, Luis Moreno, Mathew Cedeño and Karla Manzanarez

    Citation: Journal of Biological Engineering 2015 9:12

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  9. Content type: Methodology

    Chromosome engineering encompasses a collection of homologous recombination-based techniques that are employed to modify the genome of a model organism in a controlled fashion. Such techniques are widely used ...

    Authors: Sriram Tiruvadi Krishnan, M. Charl Moolman, Theo van Laar, Anne S. Meyer and Nynke H. Dekker

    Citation: Journal of Biological Engineering 2015 9:11

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  10. Content type: Letters to the Editor

    The Registry of Standard Biological Parts imposes sequence constraints to enable DNA assembly using restriction enzymes. Alnahhas et al. (Journal of Biological Engineering 2014, 8:28) recently argued that thes...

    Authors: Afnan Azizi, Wilson Lam, Hilary Phenix, Lioudmila Tepliakova, Ian J Roney, Daniel Jedrysiak, Alex Power, Vaibhav Gupta, Nada Elnour, Martin Hanzel, Alexandra C Tzahristos, Shihab Sarwar and Mads Kærn

    Citation: Journal of Biological Engineering 2015 9:8

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    The Erratum to this article has been published in Journal of Biological Engineering 2016 10:1

  11. Content type: Methodology

    We have developed a mixture of enzymes and chemicals that completely lyse cyanobacteria. Since the treatment involves only readily-available chemicals and simple proteins that degrade the components of the cya...

    Authors: Kunal K. Mehta, Niklaus H. Evitt and James R. Swartz

    Citation: Journal of Biological Engineering 2015 9:10

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  12. Content type: Research

    Conventional experiments in small scale are often performed in a ‘Black Box’ fashion, analyzing only the product concentration in the final sample. Online monitoring of relevant process characteristics and par...

    Authors: S. J. Wewetzer, M. Kunze, T. Ladner, B. Luchterhand, S. Roth, N. Rahmen, R. Kloß, A. Costa e Silva, L. Regestein and J. Büchs

    Citation: Journal of Biological Engineering 2015 9:9

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  13. Content type: Review

    3D Printing promises to produce complex biomedical devices according to computer design using patient-specific anatomical data. Since its initial use as pre-surgical visualization models and tooling molds, 3D ...

    Authors: Helena N Chia and Benjamin M Wu

    Citation: Journal of Biological Engineering 2015 9:4

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  14. Content type: Research

    Unlike bone tissue, articular cartilage regeneration has not been very successful and has many challenges ahead. We have previously developed injectable hydrogels using photopolymerizable chitosan (MeGC) that ...

    Authors: Jinku Kim, Brian Lin, Soyon Kim, Bogyu Choi, Denis Evseenko and Min Lee

    Citation: Journal of Biological Engineering 2015 9:1

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  15. Content type: Research

    Cotton is an important domesticated fiber used to manufacture a variety of products and industrial goods. During harvesting with cotton strippers and cotton pickers, it is contaminated with foreign matter from...

    Authors: Adnan Mustafic, Changying Li and Mark Haidekker

    Citation: Journal of Biological Engineering 2014 8:29

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  16. Content type: Letters to Editor

    The Registry of Standard Biological Parts only accepts genetic parts compatible with the RFC 10 BioBrick format. This combined assembly and submission standard requires that four unique restriction enzyme site...

    Authors: Razan N Alnahhas, Ben Slater, Yunle Huang, Catherine Mortensen, Jordan W Monk, Yousef Okasheh, Marco D Howard, Neil R Gottel, Michael J Hammerling and Jeffrey E Barrick

    Citation: Journal of Biological Engineering 2014 8:28

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  17. Content type: Research

    In mammalian development, the formation of most tissues is achieved by a relatively small repertoire of basic morphogenetic events (e.g. cell adhesion, locomotion, apoptosis, etc.), permutated in various seque...

    Authors: Elise Cachat, Weijia Liu, Peter Hohenstein and Jamie A Davies

    Citation: Journal of Biological Engineering 2014 8:26

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  18. Content type: Research

    Genetic material extracted from in situ microbial communities has high promise as an indicator of biological system status. However, the challenge is to access genomic information from all organisms at the popula...

    Authors: Ju Seok Lee, Junghuei Chen, Russell Deaton and Jin-Woo Kim

    Citation: Journal of Biological Engineering 2014 8:25

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  19. Content type: Methodology

    Precise spatial control and patterning of cells is an important area of research with numerous applications in tissue engineering, as well as advancing an understanding of fundamental cellular processes. Poly ...

    Authors: Mahmoud E Moustafa, Venkat S Gadepalli, Ahmed A Elmak, Woomin Lee, Raj R Rao and Vamsi K Yadavalli

    Citation: Journal of Biological Engineering 2014 8:24

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  20. Content type: Research

    Bioprocesses depend on a number of different operating parameters and temperature is one of the most important ones. Unfortunately, systems for rapid determination of temperature dependent reaction kinetics ar...

    Authors: Martin Kunze, Clemens Lattermann, Sylvia Diederichs, Wolfgang Kroutil and Jochen Büchs

    Citation: Journal of Biological Engineering 2014 8:22

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  21. Content type: Review

    First described in 2004, endometrial stem cells (EnSCs) are adult stem cells isolated from the endometrial tissue. EnSCs comprise of a population of epithelial stem cells, mesenchymal stem cells, and side popu...

    Authors: Javad Verdi, Aaron Tan, Alireza Shoae-Hassani and Alexander M Seifalian

    Citation: Journal of Biological Engineering 2014 8:20

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  22. Content type: Research

    Metal contamination is widespread and results from natural geogenic and constantly increasing anthropogenic sources (mainly mining and extraction activities, electroplating, battery and steel manufacturing or ...

    Authors: Alexandre Duprey, Viviane Chansavang, Franck Frémion, Clémence Gonthier, Yoann Louis, Philippe Lejeune, Fanny Springer, Valérie Desjardin, Agnès Rodrigue and Corinne Dorel

    Citation: Journal of Biological Engineering 2014 8:19

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  23. Content type: Research

    In prior work, a phage engineered with a biofilm-degrading enzyme (dispersin B) cleared artificial, short-term biofilms more fully than the phage lacking the enzyme. An unresolved question is whether the trans...

    Authors: Matthew Schmerer, Ian J Molineux, Dilara Ally, Jabus Tyerman, Nicole Cecchini and James J Bull

    Citation: Journal of Biological Engineering 2014 8:21

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  24. Content type: Research

    Biotechnological screening processes are performed since more than 8 decades in small scale shaken bioreactors like shake flasks or microtiter plates. One of the major issues of such reactors is the sufficient...

    Authors: Clemens Lattermann, Matthias Funke, Sven Hansen, Sylvia Diederichs and Jochen Büchs

    Citation: Journal of Biological Engineering 2014 8:18

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  25. Content type: Research

    Turbulence intensity, or hydromechanical stress, is a parameter that influences a broad range of processes in the fields of chemical engineering and biotechnology. Fermentation processes are often characterize...

    Authors: Andreas Daub, Marina Böhm, Stefanie Delueg, Markus Mühlmann, Gerhard Schneider and Jochen Büchs

    Citation: Journal of Biological Engineering 2014 8:17

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  26. Content type: Research

    In antibody purification processes, the acidic buffer commonly used to elute the bound antibodies during conventional affinity chromatograph, can damage the antibody. Herein we describe the development of seve...

    Authors: Masayuki Tsukamoto, Hideki Watanabe, Ayako Ooishi and Shinya Honda

    Citation: Journal of Biological Engineering 2014 8:15

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  27. Content type: Research

    We discuss fluorescence as a method to detect polycyclic aromatic hydrocarbons and other organic molecules, as well as minerals on the surface of Mars. We present an instrument design that is adapted from the ...

    Authors: Heather D Smith, Christopher P McKay, Andrew G Duncan, Ronald C Sims, Anne J Anderson and Paul R Grossl

    Citation: Journal of Biological Engineering 2014 8:16

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  28. Content type: Research

    The development of novel biomaterials able to control cell activities and direct their fate is warranted for engineering functional bone tissues. Adding bioactive materials can improve new bone formation and b...

    Authors: Ioana-Carmen Brie, Olga Soritau, Noemi Dirzu, Cristian Berce, Adriana Vulpoi, Catalin Popa, Milica Todea, Simion Simon, Maria Perde-Schrepler, Piroska Virag, Otilia Barbos, Gabriela Chereches, Petru Berce and Valentin Cernea

    Citation: Journal of Biological Engineering 2014 8:14

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  29. Content type: Research

    Understanding the fundamental mechanisms underlying the cellular response to topographical surface features will extend our knowledge regarding the regulation of cell functions. Analyzing the cellular response...

    Authors: Mee-Hae Kim, Yoshiko Sawada, Masahito Taya and Masahiro Kino-oka

    Citation: Journal of Biological Engineering 2014 8:13

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  30. Content type: Research

    The computational methods provide condition for investigation related to the process of drug delivery, such as convection and diffusion of drug in extracellular matrices, drug extravasation from microvessels o...

    Authors: Mostafa Sefidgar, M Soltani, Kaamran Raahemifar, Hossein Bazmara, Seyed Mojtaba Mousavi Nayinian and Majid Bazargan

    Citation: Journal of Biological Engineering 2014 8:12

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  31. Content type: Research

    Au/CuS core/shell nanoparticles (NPs) were designed as a new type of transducer agent for photothermal therapy (PTT), with attractive features of easy preparation, low cost and small size for targeting. This p...

    Authors: Ebenezer Addae, Xiuli Dong, Eric McCoy, Chang Yang, Wei Chen and Liju Yang

    Citation: Journal of Biological Engineering 2014 8:11

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  32. Content type: Research

    Osteoarthritis (OA) is a degenerative joint disease affecting approximately 27 million Americans, and even more worldwide. OA is characterized by degeneration of subchondral bone and articular cartilage. In th...

    Authors: Timothy N Snyder, Krishna Madhavan, Miranda Intrator, Ryan C Dregalla and Daewon Park

    Citation: Journal of Biological Engineering 2014 8:10

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    The Erratum to this article has been published in Journal of Biological Engineering 2014 8:27

  33. Content type: Research

    New advances enable long-term organotypic culture of colonic epithelial stem cells that develop into structures known as colonoids. Colonoids represent a primary tissue source acting as a potential starting ma...

    Authors: Asad A Ahmad, Yuli Wang, Adam D Gracz, Christopher E Sims, Scott T Magness and Nancy L Allbritton

    Citation: Journal of Biological Engineering 2014 8:9

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  34. Content type: Research

    The induction of protein synthesis by exogenous delivery of coding synthetic mRNA in desired cells is an auspicious strategy in the fields of basic cell biology, regenerative medicine, treatment of diseases, a...

    Authors: Meltem Avci-Adali, Andreas Behring, Timea Keller, Stefanie Krajewski, Christian Schlensak and Hans Peter Wendel

    Citation: Journal of Biological Engineering 2014 8:8

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  35. Content type: Methodology

    Due to their modular repeat structure, Pumilio/fem-3 mRNA binding factor (PUF) proteins are promising candidates for designer RNA-binding protein (RBP) engineering. To further facilitate the application of the...

    Authors: Zhanar Abil, Carl A Denard and Huimin Zhao

    Citation: Journal of Biological Engineering 2014 8:7

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  36. Content type: Research

    Inducible promoters are widely spread genetic tools for triggering, tuning and optimizing the expression of recombinant genes in engineered biological systems. Most of them are controlled by the addition of a ...

    Authors: Nicolo’ Politi, Lorenzo Pasotti, Susanna Zucca, Michela Casanova, Giuseppina Micoli, Maria Gabriella Cusella De Angelis and Paolo Magni

    Citation: Journal of Biological Engineering 2014 8:5

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