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  1. Content type: Research

    While hypoxia has been well-studied in various tumor microenvironments, its role in cancer cell dormancy is poorly understood, in part due to a lack of well-established in vitro and in vivo models. Hypoxic con...

    Authors: Hak Rae Lee, Faith Leslie and Samira M. Azarin

    Citation: Journal of Biological Engineering 2018 12:12

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  2. Content type: Research

    Anti-CRISPR proteins are expressed by phages as a reaction to the bacterial CRISPR–Cas defense system. Recently, the structures of anti-CRISPR proteins have been determined, and their diverse functions have be...

    Authors: Jing Li, Zengliang Xu, Aleksandr Chupalov and Mario Andrea Marchisio

    Citation: Journal of Biological Engineering 2018 12:11

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  3. Content type: Research

    Petrochemical wastewaters are highly polluting due to having various destructive materials such as aromatic hydrocarbons and heavy metal ions. Therefore, they need to be treated before disposal to the environm...

    Authors: Mahmood Derakhshan and Mojtaba Fazeli

    Citation: Journal of Biological Engineering 2018 12:10

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  4. Content type: Research

    Regulatory genes play critical roles in natural product biosynthetic pathways. Chromomycins are promising anticancer natural products from actinomycetes. This study is aimed to create an efficient strain for p...

    Authors: Lei Sun, Jia Zeng, Peiwu Cui, Wei Wang, Dayu Yu and Jixun Zhan

    Citation: Journal of Biological Engineering 2018 12:9

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  5. Content type: Methodology

    Coral reefs are colored by eukaryotic chromoproteins (CPs) that are homologous to green fluorescent protein. CPs differ from fluorescent proteins (FPs) by intensely absorbing visible light to give strong color...

    Authors: Josefine Liljeruhm, Saskia K. Funk, Sandra Tietscher, Anders D. Edlund, Sabri Jamal, Pikkei Wistrand-Yuen, Karl Dyrhage, Arvid Gynnå, Katarina Ivermark, Jessica Lövgren, Viktor Törnblom, Anders Virtanen, Erik R. Lundin, Erik Wistrand-Yuen and Anthony C. Forster

    Citation: Journal of Biological Engineering 2018 12:8

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  6. Content type: Research

    Cellulases are enzyme which have potential applications in various industries. Researchers are looking for potential cellulolytic bacterial strains for industrial exploitation. In this investigation, cellulase...

    Authors: Fouzia Tabssum, Muhammad Irfan, Hafiz Abdullah Shakir and Javed Iqbal Qazi

    Citation: Journal of Biological Engineering 2018 12:7

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  7. Content type: Research

    Regenerative medicine and tissue engineering are promising approaches for organ transplantation. Extracellular matrix (ECM) based scaffolds obtained through the decellularization of natural organs have become ...

    Authors: Huajun Yu, Yunzhi Chen, Hongru Kong, Qikuan He, Hongwei Sun, Pravin Avinash Bhugul, Qiyu Zhang, Bicheng Chen and Mengtao Zhou

    Citation: Journal of Biological Engineering 2018 12:6

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  8. Content type: Research

    Islet transplantation is increasingly used in the diabetic patients to control the blood glucose level. However, the functional output of transplanted islets remains hampered due to the local inflammation, los...

    Authors: Kelei Zhu, Leqi Dong, Jinbo Wang, Dingyao Li, Mingliang Chen, Cunbin Jiang and Jinfa Wang

    Citation: Journal of Biological Engineering 2018 12:5

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  9. Content type: Research

    Protecting drinking water supplies from pathogens such as Cryptosporidium parvum is a major concern for water utilities worldwide. The sensitivity and specificity of current detection methods are largely determin...

    Authors: L. Diéguez, M. Winter, S. Molan, P. Monis, B. King and B. Thierry

    Citation: Journal of Biological Engineering 2018 12:4

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  10. Content type: Research

    Tryptophan derivatives such as 5-hydroxytryptophan (5HTP) and serotonin are valuable molecules with pharmaceutical interest. 5HTP is presently mainly obtained by extraction from the plant Griffonia simplicifolia ...

    Authors: José-Aníbal Mora-Villalobos and An-Ping Zeng

    Citation: Journal of Biological Engineering 2018 12:3

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  11. Content type: Review

    As a family of hormones with pleiotropic effects, natriuretic peptide (NP) system includes atrial NP (ANP), B-type NP (BNP), C-type NP (CNP), dendroaspis NP and urodilatin, with NP receptor-A (guanylate cyclas...

    Authors: Shihui Fu, Ping Ping, Fengqi Wang and Leiming Luo

    Citation: Journal of Biological Engineering 2018 12:2

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  12. Content type: Letters to the Editor

    Viral infections often pose tremendous public health concerns as well as economic burdens. Despite the availability of vaccines or antiviral drugs, personal hygiene is considered as effective means as the firs...

    Authors: Yun Ha Lee, Yo Han Jang, Young-Seok Kim, Jinku Kim and Baik Lin Seong

    Citation: Journal of Biological Engineering 2018 12:1

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  13. Content type: Research

    The study of simplified, ad-hoc constructed model systems can help to elucidate if quantitatively characterized biological parts can be effectively re-used in composite circuits to yield predictable functions....

    Authors: Lorenzo Pasotti, Massimo Bellato, Michela Casanova, Susanna Zucca, Maria Gabriella Cusella De Angelis and Paolo Magni

    Citation: Journal of Biological Engineering 2017 11:50

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  14. Content type: Review

    The repair or replacement of damaged skins is still an important, challenging public health problem. Immune acceptance and long-term survival of skin grafts represent the major problem to overcome in grafting ...

    Authors: Saurabh Dixit, Dieudonné R. Baganizi, Rajnish Sahu, Ejowke Dosunmu, Atul Chaudhari, Komal Vig, Shreekumar R. Pillai, Shree R. Singh and Vida A. Dennis

    Citation: Journal of Biological Engineering 2017 11:49

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  15. Content type: Research

    Needle-free, painless and localized drug delivery has been a coveted technology in the area of biomedical research. We present an innovative way of trans-dermal vaccine delivery using a miniature detonation-dr...

    Authors: Janardhanraj Subburaj, Akshay Datey, Jagadeesh Gopalan and Dipshikha Chakravortty

    Citation: Journal of Biological Engineering 2017 11:48

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  16. Content type: Review

    The blood-brain barrier (BBB) is the interface between the vasculature and the brain, regulating molecular and cellular transport into the brain. Endothelial cells (ECs) that form the capillary walls constitut...

    Authors: John J. Jamieson, Peter C. Searson and Sharon Gerecht

    Citation: Journal of Biological Engineering 2017 11:37

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  17. Content type: Methodology

    In the past two decades, methods have been developed to measure the mechanical properties of single biomolecules. One of these methods, Magnetic tweezers, is amenable to acquisition of data on many single mole...

    Authors: Keith C. Johnson, Emilie Clemmens, Hani Mahmoud, Robin Kirkpatrick, Juan C. Vizcarra and Wendy E. Thomas

    Citation: Journal of Biological Engineering 2017 11:47

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  18. Content type: Review

    Liver disease contributes significantly to global disease burden and is associated with rising incidence and escalating costs. It is likely that innovative approaches, arising from the emerging field of liver ...

    Authors: Ogechi Ogoke, Janet Oluwole and Natesh Parashurama

    Citation: Journal of Biological Engineering 2017 11:46

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  19. Content type: Methodology

    Targeted nucleases have transformed genome editing technology, providing more efficient methods to make targeted changes in mammalian genome. In parallel, there is an increasing demand of Cre-LoxP technology f...

    Authors: Ranjita Sengupta, Amy Mendenhall, Nandita Sarkar, Chandreyee Mukherjee, Amirali Afshari, Joseph Huang and Biao Lu

    Citation: Journal of Biological Engineering 2017 11:45

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  20. Content type: Research

    Electronic lab notebooks (ELNs) are better equipped than paper lab notebooks (PLNs) to handle present-day life science and engineering experiments that generate large data sets and require high levels of data ...

    Authors: Erin M. Riley, Holly Z. Hattaway and P. Arthur Felse

    Citation: Journal of Biological Engineering 2017 11:40

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  21. Content type: Research

    Previously we demonstrated that an entire bacterial operon (the PRN operon) is expressible in plants when driven by the Tomato -yellow-leaf-curl-virus (TYLCV) -derived universal vector IL-60.

    Authors: Rita Mozes-Koch, Edna Tanne, Alexandra Brodezki, Ran Yehuda, Ofer Gover, Haim D. Rabinowitch and Ilan Sela

    Citation: Journal of Biological Engineering 2017 11:44

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  22. Content type: Research

    This study examines the effects of adding gelatin to a starch-chitosan composite foam, focusing on the altered structural and biological properties. The compressive modulus of foams containing different gelati...

    Authors: Gregory E. Risser, Brittany L. Banik, Justin L. Brown and Jeffrey M. Catchmark

    Citation: Journal of Biological Engineering 2017 11:43

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  23. Content type: Methodology

    Locomotor activity of rodents is an important readout to assess well-being and physical health, and is pivotal for behavioral phenotyping. Measuring homecage-activity with standard and cost-effective optical m...

    Authors: Andreas Genewsky, Daniel E. Heinz, Paul M. Kaplick, Kasyoka Kilonzo and Carsten T. Wotjak

    Citation: Journal of Biological Engineering 2017 11:36

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  24. Content type: Review

    The accumulated evidence points to the microenvironment as the primary mediator of cellular fate determination. Comprised of parenchymal cells, stromal cells, structural extracellular matrix proteins, and sign...

    Authors: Patrick C. Sachs, Peter A. Mollica and Robert D. Bruno

    Citation: Journal of Biological Engineering 2017 11:34

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  25. Content type: Letters to the Editor

    Oxygen-responsive promoters can be useful for synthetic biology applications, however, information on their characteristics is still limited. Here, we characterized a group of heterologous microaerobic globin ...

    Authors: Alvaro R. Lara, Karim E. Jaén, Juan-Carlos Sigala, Lars Regestein and Jochen Büchs

    Citation: Journal of Biological Engineering 2017 11:39

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  26. Content type: Research

    Aerobic granular sludge has become an attractive alternative to the conventional activated sludge due to its high settling velocity, compact structure, and higher tolerance to toxic substances and adverse cond...

    Authors: Yanan Ren, Fernanda Ferraz, Abbass Jafari Kang and Qiuyan Yuan

    Citation: Journal of Biological Engineering 2017 11:42

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  27. Content type: Research

    This article explains some simple experiments that can be used in undergraduate or graduate physics or biomedical engineering laboratory classes to learn how birdcage volume radiofrequency (RF) coils and magne...

    Authors: Dwight E. Vincent, Tianhao Wang, Thalia A. K. Magyar, Peni I. Jacob, Richard Buist and Melanie Martin

    Citation: Journal of Biological Engineering 2017 11:41

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  28. Content type: Research

    UP elements (upstream element) are DNA sequences upstream of a promoter that interact with the α-subunit of RNA polymerase (RNAP) and can affect transcription by altering the binding RNAP to DNA. However, deta...

    Authors: Qiang Yan and Stephen S. Fong

    Citation: Journal of Biological Engineering 2017 11:33

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  29. Content type: Research

    Human induced pluripotent stem cells (hiPSCs) can form any tissue found in the body, making them attractive for regenerative medicine applications. Seeding hiPSC aggregates into biomaterial scaffolds can contr...

    Authors: Meghan E. Hall, Nima Khadem Mohtaram, Stephanie M. Willerth and Roderick Edwards

    Citation: Journal of Biological Engineering 2017 11:38

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  30. Content type: Research

    The primary objective of Tissue engineering is a regeneration or replacement of tissues or organs damaged by disease, injury, or congenital anomalies. At present, Tissue engineering repairs damaged tissues and...

    Authors: Aleš Gregor, Eva Filová, Martin Novák, Jakub Kronek, Hynek Chlup, Matěj Buzgo, Veronika Blahnová, Věra Lukášová, Martin Bartoš, Alois Nečas and Jan Hošek

    Citation: Journal of Biological Engineering 2017 11:31

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  31. Content type: Research

    The antibiotic methylenomycin A is produced naturally by Streptomyces coelicolor A3(2), a model organism for streptomycetes. This compound is of particular interest to synthetic biologists because all of the a...

    Authors: Jack E. Bowyer, Emmanuel LC. de los Santos, Kathryn M. Styles, Alex Fullwood, Christophe Corre and Declan G. Bates

    Citation: Journal of Biological Engineering 2017 11:30

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  32. Content type: Research

    With additive manufacturing (AM) individual and biocompatible implants can be generated by using suitable materials. The aim of this study was to investigate the biological effects of polylactic acid (PLA) man...

    Authors: Matthias C. Wurm, Tobias Möst, Bastian Bergauer, Dominik Rietzel, Friedrich Wilhelm Neukam, Sandra C. Cifuentes and Cornelius von Wilmowsky

    Citation: Journal of Biological Engineering 2017 11:29

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  33. Content type: Review

    Due to steadily growing population and economic transitions in the more populous countries, renewable sources of energy are needed more than ever. Plant biomass as a raw source of bioenergy and biofuel product...

    Authors: Ahmed Debez, Ikram Belghith, Jan Friesen, Carsten Montzka and Skander Elleuche

    Citation: Journal of Biological Engineering 2017 11:27

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  34. Content type: Research

    In the yeast Saccharomyces cerevisiae, as in every eukaryotic organism, the mRNA 5-untranslated region (UTR) is important for translation initiation. However, the patterns and mechanisms that determine the effic...

    Authors: Jing Li, Qiang Liang, Wenjiang Song and Mario Andrea Marchisio

    Citation: Journal of Biological Engineering 2017 11:25

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  35. Content type: Research

    The molecular rotor 9-(2-Carboxy-2-cyanovinyl)julolidine (CCVJ) is presumed to have a sensitivity towards velocity or shear which is supposed to result in a change in fluorescence quantum yield. Furthermore, a...

    Authors: Markus J. Schmidt, David Sauter and Thomas Rösgen

    Citation: Journal of Biological Engineering 2017 11:24

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  36. Content type: Research

    The configuration of necrotic areas within the retinal pigmented epithelium is an important element in the progression of age-related macular degeneration (AMD). In the exudative (wet) and non-exudative (dry) ...

    Authors: Qanita Bani Baker, Gregory J. Podgorski, Elizabeth Vargis and Nicholas S. Flann

    Citation: Journal of Biological Engineering 2017 11:26

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  37. Content type: Research

    Poly(γ-glutamic acid) (γ-PGA) is a biopolymer with many useful properties making it applicable for instance in food and skin care industries, in wastewater treatment, in biodegradable plastics or in the pharma...

    Authors: Lena Regestein née Meissner, Julia Arndt, Thomas G. Palmen, Tim Jestel, Hitoshi Mitsunaga, Eiichiro Fukusaki and Jochen Büchs

    Citation: Journal of Biological Engineering 2017 11:23

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  38. Content type: Review

    Recent advances in the expansion and directed pancreatogenic differentiation of human pluripotent stem cells (hPSCs) have intensified efforts to generate functional pancreatic islet cells, especially insulin-s...

    Authors: Elena F. Jacobson and Emmanuel S. Tzanakakis

    Citation: Journal of Biological Engineering 2017 11:21

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  39. Content type: Methodology

    Escherichia coli is often used for recombinant protein production. The expression of recombinant proteins negatively affects the microbial growth, thus, a balance between protein expre...

    Authors: Tobias Ladner, Martina Mühlmann, Andreas Schulte, Georg Wandrey and Jochen Büchs

    Citation: Journal of Biological Engineering 2017 11:20

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  40. Content type: Research

    Synechococcus sp. PCC 7002 (henceforth Synechococcus) is developing into a powerful synthetic biology chassis. In order to streamline the integration of genes into the Synechococcus ch...

    Authors: Anne Ilse Maria Vogel, Rahmi Lale and Martin Frank Hohmann-Marriott

    Citation: Journal of Biological Engineering 2017 11:19

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  41. Content type: Research

    High-throughput methods based on molecular reporters have greatly advanced our knowledge of cell signaling in mammalian cells. However, their ability to monitor various types of cells is markedly limited by th...

    Authors: Zhiwen Zhang, Zachary Stickney, Natalie Duong, Kevin Curley and Biao Lu

    Citation: Journal of Biological Engineering 2017 11:18

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  42. Content type: Research

    Probiotic bacteria are becoming an important tool for improving human health, controlling diseases and enhancing immune responses. The availability of a cost effective cultivation conditions has profound effec...

    Authors: Asma Manzoor, Javed Iqbal Qazi, Ikram ul Haq, Hamid Mukhtar and Akhtar Rasool

    Citation: Journal of Biological Engineering 2017 11:17

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  43. Content type: Review

    Two important and large non-point sources of nitrogen in residential areas that adversely affect water quality are stormwater runoff and effluent from on-site treatment systems. These sources are challenging t...

    Authors: E. V. Lopez-Ponnada, T. J. Lynn, M. Peterson, S. J. Ergas and J. R. Mihelcic

    Citation: Journal of Biological Engineering 2017 11:16

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  44. Content type: Research

    Umbelliferone, also known as 7-hydroxycoumarin, is a phenolic metabolite found in many familiar plants. Its derivatives have been shown to have various pharmacological and chemo-preventive effects on human hea...

    Authors: Luan Luong Chu, Ramesh Prasad Pandey, Haet Nim Lim, Hye Jin Jung, Nguyen Huy Thuan, Tae-Su Kim and Jae Kyung Sohng

    Citation: Journal of Biological Engineering 2017 11:15

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  45. Content type: Research

    Physical scaffolds are useful for supporting cells to form three-dimensional (3D) tissue. However, it is non-trivial to develop a scheme that can robustly guide cells to self-organize into a tissue with the de...

    Authors: Xiaolu Zhu, Shiva Gojgini, Ting-Hsuan Chen, Peng Fei, Siyan Dong, Chih-Ming Ho and Tatiana Segura

    Citation: Journal of Biological Engineering 2017 11:12

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  46. Content type: Research

    Nuclear magnetic resonance (NMR) technique is a powerful analytical tool in determining the presence of bacterial contaminants in complex biological samples. In this paper, a portable NMR-based (pNMR) biosenso...

    Authors: Yilun Luo and Evangelyn C. Alocilja

    Citation: Journal of Biological Engineering 2017 11:14

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